Vice President, Program Management

Uniquity Design Group; San Diego (CA); On-site; USD 180,000 - 240,000; Full time

Job summary

Uniquity Bio is seeking a Vice President of Program Management to lead late-stage development programs (Phase 2/3) and drive strategy, execution, and risk management. You will partner with cross-functional teams and report to the CEO in a fast-paced biotech environment.

The role requires an accomplished, hands-on leader with 15+ years in biotech/pharma, global trial experience, and a track record of preparing programs for potential registration and commercialization.

Qualifications

• 15+ years in biotech/pharma with substantial experience in late-stage clinical development.
• Demonstrated leadership of Phase 2 and Phase 3 programs, including global trials.
• Prior experience in immunology, allergy/inflammation, or respiratory diseases strongly preferred.

Responsibilities

• Lead end-to-end program strategy and execution for Phase 2 and Phase 3 programs.
• Lead cross-functional team meetings to drive decision making and timelines.
• Contribute to development strategies to support regulatory approval and lifecycle planning.
• Ensure alignment of program goals with corporate objectives, investor expectations, and milestones.
• Oversee integrated program plans supporting global Phase 2b/3 trials, including timelines and budgets.
• Coordinate with Regulatory affairs to prepare for key interactions and submissions.

Skills

Late-stage development

Global trials

Team leadership

Immunology

Regulatory filings

Cross-functional leadership

Strategic program management

Job description

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Vice President, Program Management

Full Time Malvern, PA, US

5 days ago Requisition ID: 1007

Uniquity Bio is a clinical-stage biotechnology company committed to putting science and patients first. We exist to develop transformative new medicines for immune-mediated diseases, and we’re looking for bright-minded professionals driven by a desire to advance science and make a difference for people in need. Our lead asset, solrikitug, is a highly-potent TSLP inhibitor now in Phase 2 clinical trials for asthma, chronic obstructive pulmonary disorder (COPD), and eosinophilic esophagitis (EoE) indications.

Join us in building an organization where people and science thrive together. You’ll have the opportunity to make a meaningful impact while working alongside a talented, agile team in an environment where ideas move quickly, colleagues are trusted, and quality remains a cornerstone.

Position Overview

The Vice President of Program Management drives the strategic and operational execution of the company’s late-stage (Phase 2 and Phase 3) development programs. This position will report to the CEO and is a key member of the leadership team. This individual will drive integrated program strategy, execution and decision making partnering closely with cross-functional leaders to ensure clinical and regulatory success, and deliver critical value inflection points in a lean, fast‑paced biotech environment.

This role requires a highly experienced, hands‑on leader with deep expertise in late-stage clinical development, who can successfully navigate complexity, manage cross functional relationships, and prepare programs for potential registration and commercialization.

Key Responsibilities

• Lead the end-to-end program strategy and execution for Phase 2 and Phase 3 programs.
• Lead team cross functional team meetings to drive decision making and timelines by synthesizing complexity into clear decision options and plans of action.
• Contribute to development strategies to support regulatory approval, label optimization, and lifecycle planning.
• Ensure clear alignment of program goals with corporate objectives, investor expectations, and clinical/regulatory milestones.
• Oversee integrated program plans supporting global Phase 2b/3 clinical trials, including timelines, budgets, and critical path activities.
• Partner closely with Clinical Development, Clinical Operations, Biostatistics, Regulatory and CMC to ensure trial execution excellence.
• Anticipate and proactively mitigate risks related to enrollment, endpoints, regulatory expectations, and data integrity.
• Prepare and deliver communications for Board meetings highlighting key risks, risk mitigation strategies, and progress against timelines and deliverables.
• Collaborate with Regulatory Affairs to prepare for key interactions (e.g., End-of-Phase 2, pre‑BLA/NDA meetings, and global regulatory submissions).
• Support development of target product profiles and differentiation strategies in competitive immunology markets.
• Ensure programs are aligned with future commercialization considerations (e.g., payer expectations, labeling, and evidence generation).

Cross‑Functional Leadership

• Act as the central driver of alignment across functions including Clinical, Regulatory, CMC, Commercial, and Quality.
• Lead program governance meetings and ensure timely, high‑quality decision‑making.
• Ensure accountability, performance, and integration of external activities into overall program execution.

Operational Infrastructure & Governance

• Establish fit‑for‑purpose program management frameworks tailored to late-stage development in a small biotech setting.
• Develop clear and concise program reporting for executive leadership, Board of Directors, and investors.
• Drive scenario planning and contingency strategies to enable rapid decision‑making.

Leadership & Team Development

• Build and lead a small, high‑performing Program Management team.
• Serve as a “player‑coach,” remaining deeply engaged in program execution while developing team capabilities.
• Foster a culture of urgency, accountability, and collaboration.

Qualifications

Education & Experience

• 15+ years in biotech/pharma with substantial experience in late-stage clinical development.
• Demonstrated leadership of Phase 2 and Phase 3 programs, including global trials.
• Prior experience in immunology, allergy/inflammation, or respiratory diseases strongly preferred.
• Experience in small biotech or startup environments highly desirable.
• Deep understanding of TSLP biology or related epithelial cytokine pathways preferred.
• Strong knowledge of immunology clinical endpoints, biomarkers, and competitive landscape.
• Experience with regulatory filings (BLA/NDA/MAA) and health authority interactions.

Leadership & Execution Skills

• Proven ability to lead complex, cross‑functional programs in a matrix environment.
• Highly hands‑on with the ability to operate at both strategic and tactical levels.
• Strong risk management, problem‑solving, and decision‑making capabilities.
• Exceptional communication skills, including Board-level presentations.

At Uniquity Bio, we believe every team member has an impact on the patients we aim to serve. We are a nimble team with a rigorous approach to drug development that requires collaboration and transparency to maximize value, reduce risk, and deliver meaningful, best‑in‑class products. We are looking for self‑starters who enjoy working in a complex, collaborative environment and are motivated to bring critical new medicines to people around the world. We are a small, fast‑paced organization with a talented team of in‑house employees and external consultants. Candidates must be self‑motivated and able to work both independently and collaboratively to achieve success and impact in our dynamic work environment.

This is a U.S.-based position. Team members who live within commuting distance of our Malvern, PA or San Diego, CA office locations are expected to spend time in the office, and remote employees are expected to travel to an office on a regular basis. Specific details for both local and remote staff will be discussed and agreed upon on a case‑by‑case basis with the employee’s manager. Business travel may be required depending upon the specific needs of the position.

The above job description is not intended to be all-inclusive. Requirements of the position may change from time to time based on business needs.

Uniquity Bio is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All employment decisions are based on business needs, job requirements, and individual qualifications, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.