Vice President, Manufacturing and Engineering

Xeris Pharmaceuticals Inc; United States; On-site; USD 279,000 - 419,000; Full time

Benefits offered by this job

Equity incentives

Annual bonus

Health, vision, dental

401(k) plan

Job summary

The Vice President, Manufacturing & Engineering at Xeris Pharmaceuticals Inc. leads four pillars—Commercial Manufacturing & Supply Chain Logistics, MS&T, Process Innovation & Life Cycle Management, and Device Development—within a strict contract manufacturing ecosystem.

Based in Chicago, this executive drives end-to-end product strategy from clinical development through commercial launch, oversees global CMOs, and ensures cGMP compliance, quality, and regulatory readiness across small molecules,

Qualifications

• Bachelor’s degree required, strong preference for Chemical Engineering; advanced degree preferred.
• 22+ years in pharmaceutical/biotech with executive leadership in manufacturing/engineering.
• Experience with small molecules, peptides, biologics across dosage forms.
• Deep knowledge of cGMPs and global regulatory submissions.
• Experience managing external/outsourced CMO networks globally.
• Strong executive presence and strategic communication with executives and partners.

Responsibilities

• Provide strategic direction to four functional leaders (Commercial Manufacturing, MS&T, Process Innovation & LCM, Device Development).
• Drive cross-functional alignment and eliminate silos across the department.
• Direct product strategy across portfolio from clinical to commercialization and Life Cycle Management.
• Oversee global network of CMOs: vendor evaluation, negotiations, capex, alliances.
• Accountable for end-to-end supply chains from raw materials to finished goods.
• Guide development of combination products and device integration.
• Maintain regulatory accountability for submissions and health authority interactions.
• Drive budgeting, capacity planning and overall financial management.

Skills

Executive leadership

CMO management

Regulatory expertise

Strategic planning

Cross-functional leadership

cGMP knowledge

Budget management

Product lifecycle

Education

Chemical Engineering

MS/PhD/MBA preferred

Job description

Job Description: The Vice President, Manufacturing & Engineering serves as a core executive leader within PDTO, providing strategic, multi-disciplinary oversight across Xeris’s entire outsourced manufacturing, supply chain, and device engineering functions. Operating strictly within a contract manufacturing ecosystem, this executive leads four distinct functional pillars: Commercial Manufacturing & Supply Chain Logistics, Manufacturing Science & Technology (MS&T), Process Innovation & Life Cycle Management, and Device Development. The primary mandate for this position is to ensure seamless integration and flawless execution across a highly diverse portfolio that spans small molecules, peptides, and biologics, in both oral solid and complex injectable dosage forms. The Vice President will guide products through the entire lifecycle continuum—from clinical development and process scale-up through commercial launch, combination product/device integration, and post-approval Life Cycle Management (LCM)—while ensuring uncompromising product quality and regulatory compliance.

Essential Job Functions

Executive Departmental Leadership

Provide strategic direction and executive management to four specialized functional leaders (Commercial Manufacturing, MS&T, Process Innovation & LCM, and Device Development). Drive cross-functional alignment and eliminate operational silos across the department.

Multi-Disciplinary Product Strategy

Direct overarching operational strategies for a diverse product portfolio (small molecules, peptides, biologics) across varied dosage forms (oral solids, advanced injectables) from clinical phases through commercialization and Life Cycle Management.

Outsourced Network Governance

Serve as the senior executive sponsor for Xeris’s global network of Contract Manufacturing Organizations (CMOs). Establish and oversee strategies for vendor evaluation and selection, contract negotiations, capital expenditures, and vendor alliances to ensure capacity, quality, and financial efficiency.

End-to-End Supply Chain Activities

Accountable for all aspects of Xeris’s pharmaceutical supply chains ranging from raw materials to finished product inventories.

Process Innovation & Life Cycle Management

Provide executive guidance and resource prioritization for complex, high-stakes technical initiatives, including the scale-up of novel formulation technologies (e.g., XeriJect) and commercial LCM projects (e.g., second sourcing, line extensions, etc.).

Combination Product & Device Integration

Oversee the strategic intersection of Xeris’s proprietary formulation platforms with advanced delivery devices, ensuring robust engineering frameworks, Design Controls, and seamless commercial execution.

Regulatory Accountability

Maintain ultimate technical accountability for the manufacturing and device sections of global regulatory submissions (INDs, IMPDs, NDAs, BLAs, MAAs) and lead technical strategy during Health Authority interactions and Pre-Approval Inspections (PAIs).

Strategic Financial Management

Drive goal setting, capacity planning, and overarching budget development across all four functional pillars, aligning departmental spending with corporate profitability targets.

Skills and Qualifications

Bachelor’s degree required, with a strong preference for Chemical Engineering. Degrees in Mechanical Engineering, Pharmaceutical Sciences, or related fields will be considered, commensurate with extensive, highly relevant operational experience. An advanced degree (M.S., Ph.D., or MBA) is strongly preferred. Minimum of 22+ years of experience in the pharmaceutical or biotechnology industry with a proven track record of executive leadership across manufacturing and engineering functions. Deep, hands-on expertise spanning a wide range of products (small molecules, peptides, biologics) and diverse dosage forms (oral solids, complex injectables). Comprehensive mastery of the drug development continuum, with proven success navigating clinical manufacturing, commercial process validation, combination product/device development, and post-approval Life Cycle Management. Demonstrated executive experience managing external/outsourced CMO networks globally. Strong technical understanding of cGMPs, FDA/EMA regulations, and global regulatory submission requirements. Exceptional executive presence, with the ability to manage complex internal team dynamics, mentor senior leaders, and communicate strategically with the Executive Management Team and external partners.

Working Conditions

Position may require periodic evening and weekend work, as necessary to fulfill obligations. Periodic overnight travel may be required. This position is based in Xeris’ Chicago Headquarters and requires a minimum of four days per week in the office. On‑site requirements may change at management’s discretion. #LI-ONSITE

Salary

The anticipated base salary range for this position is $279,200 - $418,800. We are committed to offering competitive compensation. Starting pay is determined based on a variety of factors, including the role, job-related knowledge, skills, experience, education, internal equity, market data, and the location of the role, where applicable.

Equity and Bonuses

Employees are eligible for equity or long-term incentive awards, where applicable. Field Sales role employees are eligible for a quarterly commission structure. Non‑Sales role employees are eligible for an annual bonus. The Company also offers a comprehensive benefits package that includes additional elements such as paid time off benefits, various health, vision, and dental insurance options, 401(k) retirement benefits and more for eligible employees. Details about these and other offerings will be provided at the time a conditional offer of employment is made. Candidates are always welcome to inquire about our compensation and benefits package during the interview process. Individuals hired as temporary employees, interns, and preceptors are not eligible for commissions, bonuses, and/or long-term incentive or equity awards. Eligibility for other benefits will be based on plan documents.

Accessibility & Reasonable Accommodations

If, because of a medical condition or disability, you require a reasonable accommodation or assistance to complete any part of the application process, please send an e‑mail to [e-mail] and identify the type of accommodation or assistance you are requesting. Please include the job requisition number in your message. Please note if your request is not for this stated purpose, you will not receive a response to your email. Do not include any medical or health information in this email.

E‑Verify Participation

Xeris participates in E‑Verify. E‑Verify Participation Poster EEO is the Law EEO is the Law EEO is the Law Supplement EEO is the Law Supplement Pay Transparency Nondiscrimination Provision Pay Transparency Nondiscrimination Provision Xeris is a growth-oriented biopharmaceutical company committed to improving patient lives by developing and commercializing innovative products across a range of therapies. Xeris is headquartered in Chicago, Illinois and has a strong foundation built on proprietary formulation technologies and deep expertise in clinical development and commercialization.

Equal Employment Opportunity

Xeris Pharmaceuticals, Inc. (the “Company”) is an equal opportunity employer and does not discriminate based on race, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, veteran status, genetics or any other characteristic protected by law. All qualified candidates are given equal opportunity and the Company’s employment selection decisions are based solely on job-related factors.