Vice President, Clinical Pharmacology & Pharmacometrics

Recursion; New York (NY); Remote; USD 322,000 - 443,000; Full time

Job summary

Recursion, a clinical-stage TechBio company, seeks a visionary VP of Clinical Pharmacology & Pharmacometrics to define enterprise strategy across pharmacology, modeling, and translational science from first-in-human planning to registrational development. Lead a multidisciplinary team and collaborate with FDA/authorities to accelerate dosage decisions and labeling strategies.

You will shape AI-enabled pharmacology workflows, oversee cross-functional programs, and represent Recursion in

Qualifications

• Advanced degree in clinical pharmacology, pharmacometrics, pharmaceutical sciences, quantitative pharmacology, biomedical engineering, medicine, pharmacy, or a related field; PhD, PharmD, or MD preferred
• 15+ years of biotech or pharmaceutical industry experience, including leadership in Clinical Pharmacology, Pharmacometrics, Quantitative Pharmacology, or model-informed drug development
• Proven success leading clinical pharmacology strategy across multiple programs, from FIH to registrational development, submission and labeling
• Deep expertise in PK, PK/PD, exposure–response, exposure–safety, population PK, PBPK, QSP, dose optimization, and model-based trial design
• Experience designing, interpreting, and defending clinical pharmacology studies for global development and regulatory submissions
• Strong understanding of FDA/EMA/MHRA/PMDA/ICH expectations for clinical pharmacology and regulatory documentation
• Demonstrated ability to build and lead high-performing teams and communicate complex quantitative concepts to executives and regulators

Responsibilities

• Set enterprise strategy for Clinical Pharmacology, Pharmacometrics, Translational Modeling, and preclinical-to-clinical data integration
• Own dose strategy from FIH through registrational development and label justification
• Lead quantitative development approaches including population PK, PK/PD, exposure–response, PBPK, QSP and trial simulations
• Design and oversee clinical pharmacology studies including DDI, organ impairment, QT safety, bioavailability, ADME, and special populations
• Partner cross-functionally to inform development strategy and decision-making
• Represent clinical pharmacology in regulatory interactions and ensure high-quality contributions to submissions and labeling
• Build, mentor, and scale a high-performing Clinical Pharmacology and Pharmacometrics function
• Advance AI, automation, and analytics to improve evidence integration and decision making

Skills

Clinical Pharmacology

Pharmacometrics

Model-informed Drug Development

Dose Strategy

Regulatory Strategy

Cross-functional Leadership

AI in Pharmacology

Education

Advanced degree in clinical pharmacology

PhD/PharmD/MD preferred

Tools

Population PK

PK/PD

PBPK

QSP

Exposure-Response Modeling

Clinical Trial Simulations

Job description

Vice President, Clinical Pharmacology & Pharmacometrics

New York, New York

Your work will change lives. Including your own.

As Vice President, Clinical Pharmacology & Pharmacometrics, you will set the enterprise strategy for clinical pharmacology, pharmacometrics, and model-informed drug development across Recursion’s advancing clinical portfolio.

You will be accountable for translating nonclinical, translational, biomarker, clinical, and quantitative data into development decisions that help us select the right dose, regimen, population, and study design for each program. Your team will bring together expertise across Clinical Pharmacology, Pharmacometrics, Translational Modeling, and preclinical PK/PK-PD, with close partnership across Toxicology, DMPK, Nonclinical Safety, Clinical Biomarkers, Clinical Development, Regulatory, Biostatistics, CMC, Data Science, and Portfolio Strategy.

This is a highly strategic leadership role for a clinical pharmacology leader who can operate from first-in-human planning through registrational development, regulatory submission, and label strategy. You will build and scale the clinical pharmacology function, represent Recursion in health authority interactions, and help define how clinical pharmacology and pharmacometrics should work in an AI-native TechBio company.

In this role, you will:

• Set the enterprise strategy for Clinical Pharmacology, Pharmacometrics, Translational Modeling, and preclinical-to-clinical quantitative integration across Recursion’s clinical and post-candidate nomination portfolio
• Own dose strategy from first-in-human planning through registrational development, including dose escalation, dose optimization, exposure-response, safety, efficacy, and label-supporting dose justification
• Lead quantitative development approaches, including population PK, PK/PD, exposure-response, PBPK, QSP, disease progression modeling, and clinical trial simulations
• Design and oversee clinical pharmacology studies, including food effect, DDI, organ impairment, QT/cardiac safety, bioavailability/bioequivalence, mass balance/ADME, and special population studies
• Partner cross-functionally with Clinical Development, Development Sciences, DMPK, Toxicology, Translational Modeling, Biomarkers, Regulatory, Biostatistics, CMC, and Data Science to inform development strategy and decision-making
• Represent Recursion as the clinical pharmacology expert in regulatory interactions and ensure high-quality clinical pharmacology contributions to INDs/CTAs, briefing books, NDAs/BLAs/MAAs, regulatory responses, and labeling
• Represent Clinical Pharmacology and Translational Modeling in cross-functional program teams, governance forums, regulatory interactions, and alliance settings with Recursion’s external pharma partners
• Build, mentor, and scale a high-performing Clinical Pharmacology and Pharmacometrics function, including internal talent, consultants, CROs, and external modeling partners
• Advance the responsible use of AI, automation, and advanced analytics to improve evidence integration, modeling workflows, and clinical development decisions

The Team You'll Join:

You will join Recursion’s Clinical Development organization, reporting to the Chief Medical Officer. The Clinical Development team is an empowered, execution-minded group responsible for translating Recursion’s innovative science into medicines for patients.

You will work closely with leaders across Development, Regulatory, Development Sciences, Clinical Operations, Data Science, Biology, Chemistry, Portfolio Strategy, Communications, Legal/Compliance, and future commercialization functions. Together, you will help ensure Recursion’s clinical programs are informed by robust evidence, external medical insight, patient need, and the full potential of the RecursionOS.

The Experience You'll Need:

• Advanced degree in clinical pharmacology, pharmacometrics, pharmaceutical sciences, quantitative pharmacology, biomedical engineering, medicine, pharmacy, or a related field; PhD, PharmD, or MD preferred
• 15+ years of biotech or pharmaceutical industry experience, including significant leadership experience in Clinical Pharmacology, Pharmacometrics, Quantitative Pharmacology, or model-informed drug development
• Proven success leading clinical pharmacology strategy across multiple programs, ideally from first-in-human studies through registrational development, submission, and labeling
• Deep expertise in PK, PK/PD, exposure-response, exposure-safety, population PK, PBPK, QSP, dose optimization, dose justification, and model-based clinical trial design
• Experience designing, interpreting, and defending clinical pharmacology studies and analyses in support of global development and regulatory submissions
• Strong understanding of FDA, EMA, MHRA, PMDA, and ICH expectations for clinical pharmacology, pharmacometrics, dose selection, MIDD, and regulatory documentation
• Demonstrated ability to build and lead high-performing teams, influence senior stakeholders, manage external partners, and communicate complex quantitative concepts clearly to executives, program teams, partners, and regulators
• Experience in oncology, rare disease, and/or small molecule development strongly preferred; experience applying AI, advanced analytics, or automation in clinical pharmacology is a plus

Working Location & Compensation:

Making NYC your home base is ideal, however, we will consider remote work for this position. Remote employees must commit to regular on-site visits for routine work and departmental events.

At Recursion, we believe that every employee should be compensated fairly. Based on the skills, experience, and qualifications needed for this role, the estimated annual base salary range is:

• New York City, San Francisco Bay Area, & Boston area(s): $353,980 to $443,080
• All other US locations: $321,800 to $402,800

In addition to base salary, this role is eligible for an annual bonus, equity compensation, and a comprehensive benefits package.

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The Values We Hope You Share:

• We act boldly with integrity. We are unconstrained in our thinking, take calculated risks, and push boundaries, but never at the expense of ethics, science, or trust.
• We care deeply and engage directly. Caring means holding a deep sense of responsibility and respect - showing up, speaking honestly, and taking action.
• We learn actively and adapt rapidly. Progress comes from doing. We experiment, test, and refine, embracing iteration over perfection.
• We move with urgency because patients are waiting. Speed isn’t about rushing but about moving the needle every day.
• We take ownership and accountability. Through ownership and accountability, we enable trust and autonomy—leaders take accountability for decisive action, and teams own outcomes together.
• We are One Recursion. True cross-functional collaboration is about trust, clarity, humility, and impact. Through sharing, we can be greater than the sum of our individual capabilities.

Our values underpin the employee experience at Recursion. They are the character and personality of the company demonstrated through how we communicate, support one another, spend our time, make decisions, and celebrate collectively.

More About Recursion

Recursion (NASDAQ: RXRX) is a clinical-stage TechBio company decoding biology to radically improve lives. Recursion is advancing a portfolio of differentiated investigational medicines across its wholly owned and partnered pipeline in oncology, rare disease, neuroscience, immunology, and other therapeutic areas with significant unmet need. Enabling its mission is the Recursion OS, an AI-native, end-to-end drug discovery and development platform integrating biology, chemistry, and clinical development into a unified intelligence system. Powered by proprietary multimodal data, purpose-built AI models, and bilingual teams fluent in both science and AI, the Recursion OS is designed to translate complex science into medicines that matter — faster, better, and at scale — for patients who are waiting. Recursion’s platform infrastructure is anchored in Salt Lake City, Utah and Milton Park, Oxfordshire, where its automated biology and chemistry laboratories generate proprietary data at industrial scale. Recursion also maintains offices in New York, Montréal, and London, three global hubs for talent and leadership at the intersection of AI and scientific innovation. Learn more at www.recursion.com, or connect on X and LinkedIn.

Recursion is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation.

Accommodations are available on request for candidates taking part in all aspects of the selection process.

Recursion leverages AI in our hiring process. We use Greenhouse's Talent Matching AI technology feature to help review applications against the skills and experience we've identified as important for this role. It analyzes your resume and application responses to assess how closely your qualifications match our criteria - but all decisions are made by our human recruiters and hiring managers, including whether to move to the next phase of review. Talent Matching does not automatically advance or reject any candidate. By submitting your application, you acknowledge that you have been informed about and consent to this use of the Talent Matching tool in our review process. Please refer to our Recursion Privacy Policy at https://www.recursion.com/privacy-notice/ for more information about our processing of personal data and your rights.

Recruitment & Staffing Agencies: Recursion Pharmaceuticals and its affiliate companies do not accept resumes from any source other than candidates. The submission of resumes by recruitment or staffing agencies to Recursion or its employees is strictly prohibited unless contacted directly by Recursion’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Recursion, and Recursion will not owe any referral or other fees. Our team will communicate directly with candidates who are not represented by an agent or intermediary unless otherwise agreed to prior to interviewing for the job.

Equal Opportunity Employment Information (Recursion)

We are committed to a high-performing workplace where everyone feels like they belong and can do the best work of their careers. We reward merit and contribution as we strive for a workplace that reflects the communities in which we operate and the patients we intend to serve. To this end, we invite you to self-identify your race/ethnicity and gender. This information will be kept confidential and will not be used to favor or discriminate against any candidate. It will not be shared with the hiring managers or otherwise considered as part of your application. Submission of this information is voluntary and refusal to provide any or all of the information requested will not subject you to any adverse treatment.