Value Architecture Director

Vertex Pharmaceuticals Inc (US); Boston (MA); Hybrid; USD 181,000 - 271,000; Full time

Job summary

Vertex Pharmaceuticals is seeking a Director of FP&A, Value Architecture to lead the development and management of the value case for AI transformation initiatives. You will partner with Digital, Technology and Engineering, Finance, Portfolio Strategy, and the CFO organization to ensure credible, grounded, and measurable value cases across the portfolio.

You will define value hypotheses, KPIs, methods, and connect value cases to budgets and long-range planning while tracking realization and

Qualifications

• 10+ years in value management, strategic finance, consulting, or analytics.
• Experience building value cases for large-scale transformation programs.
• Pharma/biotech or science-driven industry experience preferred; leadership experience.

Responsibilities

• Define value hypotheses, KPIs, and measurement methods for initiatives.
• Link value cases to budget, forecast, and long-range plans.
• Track projected versus realized value and report portfolio status.
• Support affordability analysis and governance processes.

Skills

Value case development

Benefits realization

Investment appraisal

Financial modeling

KPIs & measurement

Excel

PowerPoint

Data storytelling

Collaboration with Finance

Education

Bachelor's degree in finance, economics, engineering, strategy, or related field

MBA or advanced analytics preferred

Tools

Excel

PowerPoint

BI tools

Financial planning software

Job description

Job Description General/Position Summary

The Director of FP&A, Value Architecture leads development and management of the value case for AI transformation initiatives, including the value hypothesis, financial model, KPIs, and measurement approach. The role partners with Digital, Technology and Engineering, Finance, Portfolio Strategy, functional leaders, and the CFO organization to ensure value cases are credible, operationally grounded, affordable, and measured consistently. This role provides the evidence base for portfolio-level value reporting and investment decisions, helping leaders understand value drivers, risks, opportunities, and business KPIs across the transformation portfolio.

Key Duties & Responsibilities

Value Case Development

• Define the value hypothesis, KPIs, and measurement approach for each initiative at initiation.
• Develop and maintain consistent value architecture standards, assumptions, definitions, and methods.
• Partner with functional leads and SMEs to ground value hypotheses in operational reality.

Planning, Forecasting, and Business Partnership

• Connect initiative value cases to budget, forecast, and long-range planning processes.
• Analyze trends, risks, opportunities, and business KPIs to improve decision making and forecast accuracy.
• Develop analytics and reporting that communicate value drivers, affordability, and expected ROI.

Value Realization Tracking

• Track projected versus realized value and maintain a clear portfolio view of value realization.
• Reconcile realized value with original investment theses and identify areas on track, at risk, or requiring revision.
• Provide evidence to Portfolio Strategy to inform sequencing, acceleration, and stop decisions.

Financial Partnership, Controls, and Governance

• Partner with DTE on cost-to-run modeling and total cost of ownership.
• Partner with Finance on affordability analysis and investment governance inputs.
• Support close, accrual, and governance processes requiring documentation, control awareness, or SOX-compliant discipline.

Portfolio Value Coordination

• Maintain an auditable record of value cases, KPIs, assumptions, and realization outcomes.
• Provide the evidence base for portfolio-level value reporting and future investment decisions.
• Direct and quality-control partner Value Architects embedded in delivery teams.

Required Education Level

Bachelor's degree in finance, economics, engineering, strategy, or a related field required. Advanced degree, such as an MBA or master's degree in economics or analytics, preferred.

Required Experience

Typically requires 10 or more years of experience in value management, strategic finance, consulting, or business analytics, or equivalent education and experience. Experience building and tracking value cases for large-scale transformation or investment programs. Experience with affordability modeling, cost-to-run, total cost of ownership, and cross-functional initiative coordination. Pharmaceutical, biotech, or science-driven industry experience preferred. People management or team leadership experience required.

Required Knowledge/Skills

Expertise in value case development, benefits realization, investment appraisal, and financial modeling. Ability to define rigorous KPIs and measurement frameworks that are analytically sound and operationally practical. Strong analytical and critical thinking skills, including the ability to challenge assumptions and identify flawed logic. Excellent communication and data storytelling skills for senior and executive audiences. Strong collaboration and influence skills with Finance, DTE, functional leaders, and portfolio stakeholders. Expertise with Excel and PowerPoint required; knowledge of planning, BI, and visualization tools preferred. Continuous improvement mindset and ability to adapt as priorities, governance, and reporting needs evolve.

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Pay Range: $180,700 - $271,100

Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation: Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune's 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people's lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.