Upstream Bioprocess Development Scientist

Indiana Ag Connection; Indianapolis, Northern (IN, KY); Hybrid; USD 110,000 - 140,000; Full time

Benefits offered by this job

Relocation packages

Shutdowns (mid-summer & year-end)

Parental leave (8 weeks)

Flexible work arrangements

Job summary

Elanco is seeking an Upstream Bioprocess Development Scientist in Indianapolis, hybrid work environment. You will lead upstream program development from shake flasks to bioreactors, partnering with downstream, Formulations, and Analytical teams to drive innovative, robust processes.

The role requires a Bachelor's in biology-related field, 5+ years in mammalian cell culture, and strong DoE/QbD experience. Travel ~10% and collaboration across manufacturing facilities are expected.

Qualifications

• Education: Bachelor's Degree in Biology, Molecular Biology, Microbiology, or related field.
• Experience: Minimum of five years of hands-on experience working with mammalian cell lines or similar.
• Top Skills: Strong laboratory skills in cell culture and bioreactor operation; knowledge of bioprocess and DoE principles.

Responsibilities

• Conceive, plan, schedule, and execute laboratory experiments across multiple models and scales (shake flasks to bioreactors) to develop robust upstream processes for the Large Molecule portfolio.
• Apply QbD and DoE methodologies to evaluate factor interactions, optimize product quality and yield, and support regulatory initiatives.
• Maintain laboratory infrastructure and ensure biohazard and chemical safety; perform instrument maintenance and evaluate new equipment.

Skills

Cell culture / bioreactor operation

Design of Experiments (DoE)

Quality by Design (QbD)

Cross-functional collaboration

Scientific data analysis

Education

Bachelor's degree in Biology / Molecular Biology / Microbiology or related

Job description

# Upstream Bioprocess Development ScientistBack to search resultsApply to this positionFollow CompanyMore Jobs from ElancoSend to Friend**At Elanco (NYSE: ELAN) - it all starts with animals!** **As a global leader in animal health, we are dedicated to innovation and delivering products and services to prevent and treat disease in farm animals and pets.** **At Elanco, we are driven by our vision of Food and Companionship Enriching Life and our purpose - all to Go Beyond for Animals, Customers, Society and Our People.** **At Elanco, we pride ourselves on fostering a diverse and inclusive work environment. We believe that diversity is the driving force behind innovation, creativity, and overall business success. Here, you'll be part of a company that values and champions new ways of thinking, work with dynamic individuals, and acquire new skills and experiences that will propel your career to new heights.** **Making animals' lives better makes life better - join our team today!** **Your Role: Upstream Bioprocess Development Scientist** As an Upstream Bioprocess Development Scientist, you will be part of the Bioprocess Development team to deliver robust upstream platforms for Elanco's Biotherapeutic portfolio. In this role, you will be responsible for advancing upstream process development from flask models through bioreactor scales while partnering closely with Downstream, Formulations, and Analytical scientists to drive a culture of innovation and scientific excellence. **Your Responsibilities:** * Conceive, plan, schedule, and execute laboratory experiments across multiple models and scales (ranging from shake flasks to bioreactors) to develop highly robust, consistent processes for the Large Molecule portfolio.* Apply Quality by Design (QbD) principles and Design of Experiments (DOE) methodologies to evaluate multi-factor interactions, optimize product quality and yield, and support regulatory/quality initiatives.* Maintain laboratory infrastructure and an organized, clean, and safe working environment; schedule and perform instrument/equipment maintenance, evaluate new laboratory equipment, and ensure strict adherence to biohazard and hazardous chemical safety protocols.* Ensure complete technical data integrity, analyze and interpret complex datasets to inform subsequent experimental design, and communicate findings to peers, cross-functional teams, and senior leadership.* Author technical reports, SOPs/working procedures, external publications, and sections for regulatory registration submissions, while leading process troubleshooting, knowledge transfer, and providing on-site person-in-plant technical coverage at manufacturing facilities. **What You Need to Succeed (minimum qualifications):** * **Education:** Bachelor's Degree in Biology, Molecular Biology, Microbiology, or related scientific discipline (or equivalent level of experience).* **Experience:** Minimum of five years of hands-on experience working with mammalian cell lines or similar.* **Top Skills:** Strong laboratory skills in cell culture / bioreactor operation and foundational knowledge of bioprocess / Design of Experiments (DOE) principles. **What will give you a competitive edge (preferred qualifications):** * Experience with upstream cell culture scale-up and technology transfer to pilot or manufacturing facilities.* Experience working in regulated (e.g., cGMP, FDA, USDA, EMA) and BSL-1 / BSL-2 laboratory environments.* Broad exposure to or understanding of adjacent technical platforms (e.g., fermentation, analytical method development, purification, or formulation development).* Demonstrated strategic problem-solving capabilities, adaptability, and strong collaborative communication skills.* Prior experience within the Animal Health or Biopharmaceutical industry. **Additional Information:** * **Travel:** 10%* **Location:** Global Elanco Headquarters - Indianapolis, IN - Hybrid Work Environment **Don't meet every single requirement?** Studies have shown underrecognized groups are less likely to apply to jobs unless they meet every single qualification. At Elanco we are dedicated to building a diverse and inclusive work environment. If you think you might be a good fit for a role but don't necessarily meet every requirement, we encourage you to apply. You may be the right candidate for this role or other roles! **Elanco Benefits and Perks:** We offer a comprehensive benefits package focusing on financial, physical, and mental well-being while encouraging our employees to pursue our purpose! Some highlights include: * Multiple relocation packages* Two weeklong shutdowns (mid-summer and year-end) in the US (in addition to PTO)* 8-week parental leave* 9 Employee Resource Groups* Annual bonus offering* Flexible work arrangements* Up to 6% 401K matching #LI-JC1 Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status Elanco may use automated tools, including AI, to support parts of our recruitment process, such as reviewing applications against job-related criteria and/or transferrable skills. These tools help ensure a consistent, structured evaluation, but they do not make hiring decisions. All decisions involve a human reviewer. For more information on how we handle personal data, please see our Elanco Workforce Privacy Notice.