Technical SETA - Computational Biophysics with Security Clearance

Strategic Analysis Incorporated; Arlington (VA); On-site; USD 120,000 - 170,000; Full time

Job summary

Strategic Analysis, Inc. seeks a Technical SETA - Computational Biophysicist to support DARPA BTO in Arlington, VA. Requires TS/SCI clearance and PMP certification.

Full-time, onsite at DARPA headquarters with responsibilities spanning evaluation of MD simulations, data pipelines, and cross-method integration. Responsibilities include drafting technical content for briefings and transition reports, tracking milestones, and ensuring compliance with structural bioinformatics standards across

Qualifications

• Engineering, Science, or related field degree preferred.
• PMP Certification is required.
• Experience evaluating computational biology methods, data logs, and MD simulations.

Responsibilities

• Evaluates performer-designed MD simulations, analytical pipelines, and scripts to meet structural bioinformatics and free energy standards.
• Reviews methodologies for merging computational models with empirical data (cryo-EM, X-ray) using tools like GROMACS, AMBER, NAMD, PyMOL.
• Translates SME into actionable support for DARPA BTO Program Managers by tracking milestones and drafting technical content.

Skills

Python

C++

Bash

Education

Engineering, Science, or related field

PMP Certification

Tools

GROMACS

AMBER

NAMD

PyMOL

Job description

Strategic Analysis, Inc. is an Equal Opportunity Employer. Technical SETA - Computational Biophysics (TS/SCI #26-117) Job Code:26-117

Location:Arlington, VA

FT/PT Status:Full Time

Required Clearance:Top Secret SCI

Salary Range:$120k-$170k Strategic Analysis, Inc. is seeking a skilled Technical SETA - Computational Biophysicist to support the Biological Technologies Office (BTO) at the Defense Advanced Research Projects Agency (DARPA). Summary: Provides critical subject matter expertise and programmatic support to DARPA BTO Program Managers, translating foundational and mid-level biophysical principles and applied modeling experience into technical oversight, proposal evaluation, performer assessment and management for cutting-edge structural biology and biotechnology programs. Responsibilities:

• Evaluates performer-designed molecular dynamics (MD) simulations, custom analytical pipelines, and scripts (Python, C++, Bash) to ensure they meet structural bioinformatics and free energy calculation standards.
• Reviews complex methodologies for merging computational models with empirical biological data (e.g., cryo-EM, X-ray crystallography) utilizing deep conceptual knowledge of tools like GROMACS, AMBER, NAMD, and PyMOL.
• Translates domain subject matter expertise into actionable support for DARPA BTO Program Managers by tracking performer milestones, maintaining program data logs, and drafting technical content for briefings, transition reports, and new BAAs.

Degree: Engineering, Science, Business, Program Management, Operations, Public Policy, or a related field. PMP Certification is required. Clearance: TS/SCI required Work Location: Full time onsite at Arlington VA headquarters, DARPA. Strategic Analysis, Inc. is an Equal Opportunity employer and is committed to non-discrimination in employment. All qualified applicants will receive consideration for employment without regard to race, color, religions, sex (including pregnancy, sexual orientation, or gender identity), national origin, disability (physical or mental), age (40 or older), protected veteran status, genetic information (including family medical history) or any other characteristic protected by law. This policy includes but is not limited to the following employment actions: recruitment, hiring, firing, promotion, demotion, compensation, fringe benefits, training, mentoring and sponsorship programs.