Technical Development Principle Scientist

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 120,800 - 224,300; Full time

Benefits offered by this job

Discretionary annual bonus

Relocation benefits

Comprehensive company benefits

Job summary

F. Hoffmann-La Roche AG is seeking a Technical Development Principle Scientist for the Analytical Development Department in South San Francisco, California. The role involves serving as the analytical expert in a multi-disciplinary CMC team, contributing to multiple clinical therapeutics.

The ideal candidate will possess a Ph.D. or equivalent experience, and expertise in analytical techniques such as HPLC and mass spectrometry. The salary range is $120,800 – $224,300 based on qualifications, with additional benefits including relocation assistance and bonuses.

Qualifications

• Ph.D. or M.S./B.S. with additional years of experience in related disciplines.
• Sound knowledge of protein analytical characterization.
• Proficiency in relevant analytical techniques.

Responsibilities

• Design and execute analytical studies supporting process development.
• Engage with stakeholders and present data.
• Work independently and collaboratively in a fast-paced environment.

Skills

Analytical Chemistry

Biochemistry

High Performance Liquid Chromatography

Mass Spectrometry

Capillary Electrophoresis

Advanced Spectroscopy

Self-motivation

Oral communication

Written communication

Education

Ph.D. in Analytical Chemistry or related field

M.S./B.S. in Analytical Chemistry or related field

Tools

Liquid Chromatography

Spectroscopy

Job description

Job Overview

A Technical Development Principle Scientist is available in the Analytical Development Department of Pharma Technical Development. The selected candidate will serve as the analytical expert in a multi‑disciplinary CMC team and will contribute to the development of several active clinical (phase 1–3) therapeutics simultaneously.

Responsibilities

• Design and execute analytical studies that support process development and enable successful regulatory filings (IND, BLA).
• Engage with internal and external stakeholders to present data at meetings.
• Work independently and collaboratively within a fast‑paced environment to drive tasks to completion.

Required Qualifications

• Ph.D. (4–6 additional years experience) or M.S./B.S. (6–10 additional years experience) in Analytical Chemistry, Biology, Biochemistry, Chemistry, Chemical Engineering, or related discipline.
• Sound knowledge of protein analytical characterization or related therapeutic modalities.
• Proficiency in high performance liquid chromatography, liquid chromatography–mass spectrometry, capillary electrophoresis, and advanced spectroscopy, with at least one area of deep expertise.
• Knowledgeable about CMC development from Phase I to commercial stages.
• Self‑motivated with excellent organization, oral and written communication skills, and the ability to work both independently and as a team member.

Preferred Qualifications

• Experience with small‑molecule linker drugs and antibody‑drug conjugates (ADCs).
• Experience supporting IND‑enabling and BLA‑enabling activities.

Salary & Benefits

• Salary range: $120,800 – $224,300 (South San Francisco, CA) based on experience, qualifications, and geographic location.
• Discretionary annual bonus may be available.
• Relocation benefits are available.
• Position qualifies for company benefits detailed elsewhere.

Equal Employment Opportunity Statement

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to discrimination on the basis of protected veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.