T1D, Research Fellow

Vertex Pharmaceuticals; Boston (MA); Presencial; USD 197.000 - 296.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Annual bonus

Equity awards

Overtime pay (as applicable)

Medical, dental and vision benefits

Generous paid time off

Educational assistance programs

Commuting subsidy

Matching charitable donations

401(k)

Descripción de la vacante

Vertex is seeking an innovative physician-scientist to lead translational research and product strategy within the Type 1 Diabetes Research Group. This on-site role bridges clinical expertise with translational science to advance SC-islet therapies from discovery through translational development.

The successful candidate will bring deep expertise in diabetes and translational medicine, with a strong product-development mindset and the ability to contribute across the broader portfolio.

Formación

• MD and/or MD/PhD with 10+ years in translational medicine, academic medicine, biotechnology, or related settings.
• Expertise in drug development, translational science, and disease biology.
• Experience in cell therapy, stem cell biology, regenerative medicine, endocrinology, immunology, or related fields.
• Strong track record in diabetes, cell therapy, translational therapeutics, stem cell biology, or related disciplines.

Responsabilidades

• Provide disease and mechanistic insight to support product strategy, hypothesis generation, and candidate optimization.
• Serve as a physician-scientist leader for translational strategy in partnership with research, development, manufacturing, and clinical teams.
• Design and guide in vitro and in vivo studies aiming for clinical outcomes.
• Lead cross-functional projects, setting goals, priorities, timelines, budgets, and decision points.
• Integrate biological, translational, engineering, manufacturing, and clinical considerations to drive portfolio decisions and product advancement.
• Define and guide development of predictive assays, biomarkers, and translational strategies supporting product advancement.
• Interpret complex datasets and convert findings into clear program recommendations.
• Build and maintain a strong, collaborative, high-performing research culture.

Conocimientos

Translational research

Product strategy

Leadership

Clinical translation

Educación

MD/PhD

Descripción del empleo

Job Description

We are seeking an innovative physician-scientist to help lead translational research and product strategy within the Type 1 Diabetes Research Group. This role serves as a cross-functional research leader for SC-islet therapies, with additional responsibilities across the broader T1D research portfolio. The primary focus is to advance next-generation SC-islet therapies from discovery through translational development by integrating disease biology, stem cell biology, bioengineering, manufacturing, and clinical considerations. This leader will bridge clinical expertise with translational science, help direct preclinical and translational research, and guide the path toward future clinical development. The successful candidate will bring deep expertise in diabetes and translational medicine, a strong product-development mindset, and the ability to contribute across broader portfolio priorities where disease biology, product strategy, translational science, and development strategy intersect.

Key Responsibilities

• Provide disease and mechanistic insight to support product strategy, hypothesis generation, and candidate optimization.
• Serve as a physician-scientist leader for translational strategy in partnership with research, development, manufacturing, and clinical teams.
• Design and guide in vitro and in vivo studies aiming for clinical outcomes.
• Lead cross-functional projects, setting goals, priorities, timelines, budgets, and decision points.
• Integrate biological, translational, engineering, manufacturing, and clinical considerations to drive portfolio decisions and product advancement.
• Define and guide development of predictive assays, biomarkers, and translational strategies supporting product advancement.
• Interpret complex datasets and convert findings into clear program recommendations.
• Build and maintain a strong, collaborative, high-performing research culture.

Required Qualifications

• MD and/or MD/PhD in a relevant discipline with 10+ years in academic medicine, translational research, biotechnology, pharmaceutical R&D, or related settings.
• Expertise in drug development, translational science, and disease biology.
• Experience in cell therapy, stem cell biology, regenerative medicine, endocrinology, immunology, or related fields.
• Strong track record in diabetes, cell therapy, translational therapeutics, stem cell biology, or related disciplines.

Preferred Experience

• Direct experience in Type 1 Diabetes, pancreatic islet biology, stem cell biology, regenerative medicine, or cell therapy.
• Experience with translational biomarkers, predictive assays, and development candidate selection.
• Experience supporting IND-enabling strategies and translation toward first-in-human studies.
• Knowledge of transplantation biology and transplantion immunologyu
• Familiarity with FDA/EMA regulatory pathways and GCP.
• Ability to lead through expertise in a matrixed environment, communicate across disciplines, and mentor others.

Pay Range

$197,400 - $296,200

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

Benefits

• annual bonus and annual equity awards
• overtime pay, in accordance with federal and state requirements
• medical, dental and vision benefits
• generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• educational assistance programs including student loan repayment
• generous commuting subsidy
• matching charitable donations
• 401(k)

Flex Designation

On-Site Designated

Flex Eligibility Status

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.