Staff Scientist II
Yale University
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Job summary
The Yale University Chemical Metabolism Core in New Haven seeks an experienced analytical chemist/mass spectrometrist to develop and validate LC‑MS/MS assays, perform stable isotope tracing, and support metabolomics, lipidomics, and targeted quantitation across diverse research projects.
The role is bench‑based in a shared core facility, with responsibilities including method development, data processing, QC, and training users, while maintaining detailed records for reproducibility.
Qualifications
- Bachelor’s degree in Chemistry or related field with four years of related experience.
- Experience with LC–MS methods, isotope tracing, and metabolomics/lipidomics is required.
- Ability to communicate results clearly and train users.
Responsibilities
- User Training: Provide advanced training to core users.
- Experiment Support: Design and execute LC‑MS experiments and troubleshoot.
- Facility/Instrument Support: Manage core instrument operations and QC.
- Technique Development: Develop SOPs and optimize analytical methods.
Skills
Education
Tools
Job description
Department: YSM CRC - Chemical Metabolism Core
Working at Yale means contributing to a better tomorrow. Whether you are a current resident of our New Haven‑based community, eligible for opportunities through the New Haven Hiring Initiative, or a newcomer, interested in exploring all that Yale has to offer, your talents and contributions are welcome. Discover your opportunities at Yale!
The Chemical Metabolism Core is seeking a highly motivated and experienced analytical chemist/mass spectrometrist to join our team. The successful candidate will play a critical role in developing, validating, and applying targeted and untargeted LC‑MS/MS methods (including stable isotope tracing, metabolomics, and lipidomics) to support internal and external research projects across diverse disease areas. This position is primarily hands‑on at the bench and on instruments, with substantial responsibility for method development, quantitative assay deployment, and day‑to‑day operation of multiple LC‑MS platforms in a shared core environment.
- Lead development, validation, and documentation of quantitative LC‑MS/MS assays (calibration curve design, QC strategy, acceptance criteria, carryover evaluation, matrix effects, and stability assessments) suitable for multi‑user core deployment.
- Design and execute stable isotope tracer experiments (e.g., ¹³C‑glucose, ¹³C‑glutamine), including sample workup and downstream isotopologue data analysis (desired).
- Support both discovery‑oriented metabolomics/lipidomics projects and hypothesis‑driven, targeted quantitation studies for a broad user base (faculty labs, trainees, external collaborators).
- Coordinate sample intake, batching, and queue management, and communicate timelines, data quality issues, and results clearly to users with varying levels of technical expertise.
- Hands‑on experience operating, maintaining, and troubleshooting high‑resolution and/or triple quadrupole LC‑MS systems (e.g., QqQ, QTOF, Orbitrap) in a research or core facility setting.
- Strong LC skills: reversed‑phase and HILIC method development, gradient optimization, carryover mitigation, and column care.
- Routine performance of system suitability and QC monitoring (retention time stability, mass accuracy, sensitivity, and contamination checks) and implementation of preventative maintenance schedules.
- Experience with vendor‑specific MS software (e.g., Analyst, Sciex OS, Xcalibur, MassLynx, or similar) for acquisition, processing, and basic quantitation.
- Familiarity with common metabolomics/lipidomics processing tools (e.g., MS‑DIAL, El‑Maven, Skyline, XCMS, or similar) and downstream data handling in R, Python, or equivalent environments is highly desirable.
- Demonstrated ability to process large LC‑MS datasets, perform peak integration and review, apply appropriate normalization/QC strategies, and export finalized results for statistical analysis.
- Working knowledge of basic statistics relevant to quantitative LC‑MS (e.g., LOD/LOQ concepts, CV thresholds, outlier identification, batch effect recognition).
- Ability to prepare clear reports and data summaries for users, including QC metrics, limitations, and recommendations for follow‑up experiments.
- Proven experience working in a service‑oriented or collaborative environment, balancing multiple projects and stakeholders while maintaining high data quality.
- Excellent interpersonal and communication skills; ability to explain MS concepts and limitations to non‑experts and to train new users on sample preparation and best practices.
- Strong organizational skills, including maintaining detailed electronic records of methods, runs, QC performance, and instrument interventions that support lab audits and reproducibility.
- Comfort enforcing core policies (sample submission requirements, QC failure criteria, cost‑recovery or recharge policies) in a professional, transparent manner.
- Strong understanding of analytical principles and techniques.
- Excellent problem‑solving and organizational skills.
- Strong written and verbal communication skills for documentation and reporting.
- Strong team skills.
- A postgraduate degree (BS, Master’s or Ph.D.) in Chemistry, Analytical Chemistry, or a related field.
- Ph.D. or M.S. in Chemistry, Analytical Chemistry, Biochemistry, or related field, with at least 2–3 years of post‑degree, hands‑on LC‑MS experience in metabolomics, lipidomics, or related applications (industrial, core, or advanced academic setting).
- Documented track record of deploying robust LC‑MS methods (e.g., method SOPs, validated assays in use by multiple labs, or contributions to multi‑center studies).
- Proven experience advising on experimental design for MS‑based studies (sample size, replication, randomization, QC samples, and appropriate controls for tracer studies). Proven experience with quantitative and qualitative analysis, including stable isotope tracer analysis, metabolomics and lipdiomics.
- Prior experience in a core facility or shared resource environment is strongly preferred.
- User Training: Provide advanced training and guidance to users of the research core.
- Experiment Support: Collaborate with researchers on experimental design, execution, data analysis, and troubleshooting within the research core.
- Facility/Instrument Support: Manage and oversee research projects within the research core.
- Technique Development: Lead the implementation and optimization of advanced techniques and methodologies and develop standard operating procedures for research core services.
- Data Analysis/Interpretation: Analyze and interpret complex scientific data, generating meaningful insights and recommendations.
- Equipment Procurement: Assist in the selection, acquisition, and maintenance of research core equipment.
- Professional Development: Stay updated with emerging research trends and technologies. Participate in professional development activities and scientific conferences.
- Scientific Participation: Contribute scientific data for manuscript preparation and grant proposals.
- Staff Training and Mentoring: Contribute to the training and mentoring of junior staff members.
- Vendor Relations: Manage vendor relationships, negotiate contracts, and evaluate new technologies for optimal procurement processes.
- Education and Outreach: Contribute to education and outreach activities within the core, including tours, events, etc.
Bachelor’s degree in a related discipline and four years of related experience or an equivalent combination of skills, education, and experience.
10/26/2026
Professional
NON
Administration & Operations
Supervisor; Senior Associate (24)
$68,000.00 - $120,500.00
A general description of the benefits to be offered with this Managerial & Professional position is available at: Yale Benefits
Full time
Staff
On-site
All candidates for employment will be subject to pre‑employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. For additional information on the background check requirements and process visit "Learn about background checks" under the Applicant Support Resources section of Careers on the It's Your Yale website.
Certain positions have associated health requirements based on specific job responsibilities. These may include vaccinations, tests, or examinations, as required by law, regulation, or university policy.
Salary offers are determined by a candidate’s qualifications, experience, skills, and education in relation to the position requirements, along with the role’s grade profile and current internal and external market conditions.
The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specified duties and responsibilities of the position. Employees will be assigned specific job‑related duties throughout their hiring department.
The University is committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities and seeks to attract to its faculty, staff, and student body qualified persons from a broad range of backgrounds and perspectives. In accordance with this policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against any individual on account of that individual’s sex, sexual orientation, gender identity or expression, race, color, national or ethnic origin, religion, age, disability, status as a special disabled veteran, veteran of the Vietnam era or other covered veteran.
Inquiries concerning Yale's Policy Against Discrimination and Harassment may be referred to the Office of Institutional Equity and Accessibility (OIEA).
Yale University is a tobacco‑free campus.
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