STAFF SCIENTIST

LSU Health Sciences Center New Orleans; New Orleans (LA); On-site; USD 70,000 - 110,000; Part time

Job summary

LSU Health Sciences Center New Orleans is hiring a Staff Scientist to study how obesity affects tumor biology, focusing on the prostate cancer microenvironment and metabolic-epigenetic remodeling that drives therapy resistance.

The role requires leading high-throughput multi-omic workflows (RNA-seq, ChIP-seq, ATAC-seq, metabolomics) and performing CRISPR-Cas9 screens to validate targets, with a goal to identify novel therapies and publish impactful findings.

Qualifications

• PhD in Basic Science, Health Science, Bioinformatics, or related field.
• Comprehensive research experience in a biomedical lab is expected.
• Experience with multi-omic data and cancer biology is advantageous.

Responsibilities

• Design and lead projects on obesity, metabolism, and prostate cancer interactions.
• Perform multi-omic integration of RNA-seq, ChIP-seq, ATAC-seq, and metabolomics data.
• Apply CRISPR-Cas9 screens and gene editing to validate drivers of drug resistance.
• Contribute to manuscript preparation and pursue extramural funding.

Education

PhD

Tools

CRISPR-Cas9

RNA-seq

ChIP-seq

ATAC-seq

Metabolomics

Job description

Closing date: December 25, 2026

Title: STAFF SCIENTIST

Employee Type:Other Academic

Department: Center of excellence-Cancer

Campus Location:CANCER CENTER/SETON BLDG./2025

Job Summary/Basic Functions

The Staff Scientist Staff Scientist will investigate the critical intersection of host metabolic health and tumor biology. Specifically, they will study how obesity-induced systemic changes drive metabolic reprogramming and epigenetic remodeling in prostate cancer. Research will place special emphasis on how these dual mechanisms converge to promote therapeutic resistance and lineage plasticity, with the goal of identifying novel therapeutic targets.
The Staff Scientist will lead projects investigating how obesity alters the prostate tumor microenvironment, focusing on crosstalk among adipocyte-derived factors, tumor metabolism, and epigenetic states (e.g., histone modifications, DNA methylation). Uncover pathways that promote survival and lineage plasticity under therapeutic stress, including androgen deprivation therapy (ADT) and next-generation anti-androgens. They will be responsible for Multi-Omic Integration: Design and execute high-throughput multi-omic workflows that integrate data from RNA-seq, ChIP-seq, ATAC-seq, and metabolomics. The Staff Scientist will also apply CRISPR-Cas9 genetic screens and targeted gene editing to functionally validate candidates that drive drug resistance, conduct independent computational analyses and develop pipelines to interpret complex multi-omic data and, help with the preparation of high-impact manuscripts and actively pursue extramural funding.

Minimum Qualifications

Required Education:PhD

Required Field of Study:Basic Science, Health Science, Bioinformatics, or related field

Number of years required to perform the job:0 - 2 years

Type of experience required to perform the job:Experience in a research environment

Substitution:MD or DDS are also acceptable

Comprehensive benefits are available to eligible employees and their dependents including health, life, dental, and vision insurance; flexible spending accounts; retirement plans; generous annual and sick leave; 14 paid holidays per year; and an employee health primary care clinic. See following link for more details on our benefits offerings: LSUHSC, New Orleans - Benefits

Other employee benefits include a full-service credit union, wellness benefits featuring complimentary fitness center membership for employees and their spouses, employee assistance program, campus assistance program, and pet insurance option. More information about these benefits can be found on this webpage:Additional Benefits