Sr. Software Engineer, Clinical Software

Personalis; Fremont (CA); On-site; USD 150,000 - 175,000; Full time

Benefits offered by this job

Health benefits

Annual bonus

Long-term incentive units (equity)

Medical benefits

Dental benefits

Vision benefits

401(k) match

ESPP

Tuition reimbursement

Sick/vacation time

Commuter benefits/ EV charging

Onsite gym

Wellness benefits

Job summary

Personalis in Fremont, CA seeks a Sr. Software Engineer to design, develop, and maintain LIMS systems.

You will own feature development for existing systems and new cloud-based platforms, collaborating with senior engineers to deliver scalable solutions for regulated laboratory operations. You will design backend services in Python/Java, work with relational and graph databases, and deploy services on AWS, contributing to design reviews and documentation while ensuring quality and

Qualifications

• B.S. degree in Computer Science, Engineering, or a related technical field.
• 5 years of professional software development experience.
• Strong proficiency in Python or Java.
• Proven experience building and deploying applications on AWS.
• Relational databases (PostgreSQL, MySQL) and developing REST APIs.
• Experience with version control and CI/CD concepts.
• Excellent problem-solving skills and ability to work independently.

Responsibilities

• Design, develop, test, and maintain software systems and features supporting laboratory operations.
• Develop and optimize backend services and APIs using Python and/or Java.
• Implement solutions using relational and graph databases.
• Take ownership of deploying and maintaining services in our AWS cloud environment.
• Participate in code reviews, design discussions, and technical documentation.
• Troubleshoot and resolve complex technical issues in development and production environments.
• Collaborate with cross-functional teams to translate business requirements into robust technical solutions.

Skills

Python

Java

AWS

PostgreSQL

MySQL

REST APIs

CI/CD

GitHub/Bitbucket

Problem-solving

Education

B.S. degree in Computer Science, Engineering, or related technical field

Tools

Docker

Flask

FastAPI

GitHub

Bitbucket

React

Angular

Vue.js

Job description

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary

We are seeking a Sr. Software Engineer to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms. You will work with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment.

Onsite

Monday, Tuesday, and Thursday

Responsibilities

• Design, develop, test, and maintain software systems and features supporting laboratory operations.
• Develop and optimize backend services and APIs using Python and/or Java.
• Implement solutions using a variety of database technologies, including relational and graph databases.
• Take ownership of deploying and maintaining services in our AWS cloud environment.
• Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability.
• Troubleshoot and resolve complex technical issues in development and production environments.
• Collaborate with cross-functional teams to translate business requirements into robust technical solutions.

Qualifications

• B.S. degree in Computer Science, Engineering, or a related technical field.
• 5 years of professional software development experience.
• Strong proficiency in at least one programming language such as Python or Java.
• Proven experience building and deploying applications on AWS.
• Solid experience with relational databases (e.g., PostgreSQL, MySQL) and developing REST APIs.
• Experience with version control systems (e.g., Github, Bitbucket) and CI/CD concepts.
• Excellent problem-solving skills and the ability to work independently on complex tasks.

Preferred

• Experience with web frameworks like Flask or FastAPI.
• Familiarity with modern JavaScript frameworks (e.g., React, Angular, or Vue.js).
• Experience in the life sciences, healthcare, or another regulated industry.
• Familiarity with containerization technologies (e.g., Docker).
• Exposure to graph databases or NoSQL technologies.

What You'll Gain

• Opportunity to take ownership of significant features and projects from design to deployment.
• Deepen your expertise in AWS services and cloud architecture.
• Gain valuable experience working in a regulated life sciences environment.
• Clear pathways for career growth into a senior engineering role through mentorship and impactful work.

The hiring range for this position is $150,000 to $175,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates

At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical,dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)