Sr. Scientist I (Pre-formulation and Solid State Characterization)

BioSpace; Watertown (MA); On-site; USD 146,260 - 184,713; Full time

Job summary

EyePoint promotes a patient-focused retinal disease program, seeking a Sr Scientist I to advance API from discovery through development. You will collaborate across drug substance, analytical, and formulation teams to design robust pre-formulation strategies and new solid-state characterization methods.

The role requires PhD or Master in relevant fields, strong lab skills, and experience with regulatory documentation.

Qualifications

• Conduct pre-formulation studies and solid-state characterization of APIs in alignment with project goals.
• Understand drug substance attributes (solubility, polymorphism, morphology, stability) and inform formulation strategy.
• Design and execute crystallization processes with focus on form control, particle size, yield, and purity.
• Identify and deploy new solid-state characterization technologies as needed.
• Prepare pre-formulation and development reports for regulatory submissions.
• Ensure work complies with applicable policies, procedures and regulatory guidelines.

Responsibilities

• Work with Drug Substance, Analytical Development, and Formulation Development to progress API from discovery to manufacturing.
• Pre-formulation research and solid-state characterization to advance the discovery pipeline.
• Prepare pre-formulation and development reports for regulatory submissions.
• Maintain understanding of current laws and regulations in pharma/biotech.

Skills

Pre-formulation

Solid-state characterization

Lab skills

Technical writing

Collaboration

Education

PhD in Material Sciences

Master in Pharmaceutical Sciences

Tools

PLM

SEM

PXRD

TGA

DSC

DVS

NMR

FTIR

Raman

UV/Vis

Job description

The Discovery & Development team is driven by our patient-first commitment to advancing a retinal disease-focused pipeline. This function leads end-to-end R&D, from early discovery through product development, leveraging cutting-edge ophthalmology and biotechnology platforms to deliver innovative therapeutics that protect vision. By developing best-in-class, durable retinal therapies that can potentially improve outcomes and reduce treatment burden, the team plays a critical role in disrupting the treatment paradigm for serious retinal diseases.

Primary responsibilities include, but are not limited to, the following:

Work in close partnership with Drug Substance, Analytical Development, and Formulation Development to progress API from discovery to manufacturing. With expertise in pre-formulation research and solid-state characterization, play a crucial role in advancing our discovery pipeline.

Individual Responsibilities

• Conduct pre-formulation studies/solid-state characterization of active pharmaceutical ingredients (APIs) and ensure pre-formulation timelines are aligned with project goals.
• Contribute to a thorough understanding of drug substance attributes, such as solubility, polymorphism, morphology, and stability and conceive formulation strategy.
• Design and execute crystallization process with a focus on form control, particle size/morphology, yield, purity, and process understanding.
• Identify and deploy new solid state characterization technologies as needed.
• Prepare pre-formulation and pharmaceutical development reports and other technical documentation required for regulatory submissions.
• Ensure that all work is conducted in accordance with applicable policies, procedures, regulatory standards and guidelines.
• Maintain an understanding of current laws & regulations applicable to the pharmaceutical/biotechnology industry.

Primary skills and knowledge required include, but are not limited to the following:

• Expertise in pre-formulation development of small molecules.
• Strong lab skills with a Can-Do attitude; independently carry out pre-formulation research.
• Highly skilled in characterization techniques such as PLM, SEM, PXRD, TGA, DSC, DVS, NMR, FTIR, Raman, and UV/Vis.
• Skilled in independently organizing project goals and completing long-term projects on time.
• Flexible, adaptable and collaborative style with a willingness to take on new challenges and positively respond to changes.
• Possess high integrity and exceptional work ethic.
• Excellent interpersonal, technical writing, and oral communication skills.
• A team player, collaborating effectively with a broad range of internal functions.
• Versatile, driven and curious to take on new and challenging roles and responsibilities

Level Of Education Required

• PhD or Master in Material Sciences, Pharmaceutical Sciences or related discipline.

Number of Years of Experience in the Function and in the Industry:

Sr Scientist I

• PhD: at least 5 years of relevant experience in pharmaceutical industry
• Master: at least 10 years of relevant experience in pharmaceutical industry

Pay range

$146,260 - $184,713 USD

Envision Your Future

With the exciting energy of a winning culture and an exhilarating pace, we are an ophthalmology company committed to preventing blindness by developing and commercializing innovative therapeutics.

Transformational Innovation

We exist to change our patients’ lives through the power of sight. We are forward looking, embrace challenges with curiosity, and continuously seek to improve our products and ourselves by learning, problem-solving and pushing the limits of science and technology.

Unwavering Integrity

We recognize our responsibility to our patients, employees, and our community, and value the trust they put in us. We set a high ethical bar and expect responsible leadership at every level to ensure we serve those who matter most to us.

Compassionate Excellence

We believe that fun and excellence can coexist. We foster a culture where enjoying the work we do and caring for each other are as important as delivering exceptional outcomes.

Inclusive Collaboration

We strive to see through the eyes of others and work as one team. We appreciate one another’s differences and perspectives, and ensure everyone feels valued, respected and encouraged to bring their ideas forward.

EyePoint is proud to be an equal opportunity employer.

We believe that diversity and inclusion among our colleagues is critical to our success as a company, and we seek to recruit, develop, and retain the most talented people from a diverse candidate pool.

All applicants will be considered for employment without attention to age, race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.