Sr Scientist I - Biopharmaceutics

BioSpace; South San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Paid time off

Medical/dental/vision insurance

401(k)

Job summary

AbbVie is seeking a Senior Scientist I in MPDD to lead biopharmaceutics efforts, focusing on peptide and small molecule delivery. The role requires leadership in cross-functional teams to advance candidates from discovery through early clinical development, with emphasis on developability and formulation strategy.

Responsibilities include guiding CMC developability assessments, collaborating across disciplines, and contributing to regulatory readiness and future product launches.

Qualifications

• Strong understanding of biopharmaceutics related to drug absorption and peptide aggregation.
• Experience in developing and characterizing drug delivery systems to improve bioperformance.
• Knowledge of preclinical and clinical formulation development principles for small molecules and peptides.

Responsibilities

• Serve as biopharm project leader within MPDD to support discovery and early clinical programs.
• Lead peptide oral delivery programs and developability assessments for emerging molecules.
• Collaborate with discovery and development to improve delivery and enable clinical development.

Skills

Biopharmaceutics knowledge

Drug delivery concepts

Physicochemical properties

Preclinical formulation

Biopharmaceutical development

Leadership in cross-functional teams

Education

Bachelor's/Master's/PhD in Pharmaceutical Sciences/Engineering

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Job Description

The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state of the art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaborativelyprogress candidates with higher probability of success intodevelopment and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch, MPDD scientistswork in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions.

Drug Delivery scientists within AbbVie's MPDD organization work collaboratively with other functions within Development Sciences and Discovery to conduct developability assessment to select molecules with higher probability of success for clinical development and eventual commercialization. This includes profiling of physicochemical properties, development of preclinical formulations, identifying solutions to in vivo absorption challenges, and advancement of novel drug delivery strategies across multiple routes of administration that are aligned with program target product profiles and downstream partners. Modalities of interest include traditional small molecules as well as complex chemically synthesized modalities such as PROTACs and peptides. In this role, you will work in cross-functional teams in matrixed environments and engage in multidisciplinary problem solving.

AbbVie's MPDD organization is seeking a highly motivated, talented, and creative scientist with expertise and experience in biopharmaceutics, pharmaceutical science, and drug delivery for a Senior Scientist I position. The primary role of this position is to serve as a biopharm project leader within MPDD to support discovery and early clinical programs and lead peptide oral delivery programs. This individual will lead CMC developability assessment for emerging molecules on peptide and small molecule pipeline programs. This role will also entail contributing towards developing our drug delivery capabilities with a focus on complex chemically synthesized modalities. This person will be working collaboratively with discovery and development partners across disciplines to improve delivery of these modalities and advance molecules to clinical development with improved developability profiles. The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on developability, preclinical and/or clinical formulation, biopharmaceutics, and drug delivery concepts relevant to small molecules and peptides

Job Description

AbbVie's MPDD organization is seeking a highly motivated, talented, and creative scientist with expertise and experience in biopharmaceutics, pharmaceutical science, and drug delivery for a Senior Scientist I position. The primary role of this position is to serve as a biopharm project leader within MPDD to support discovery and early clinical programs and lead peptide oral delivery programs. This individual will lead CMC developability assessment for emerging molecules on peptide and small molecule pipeline programs. This role will also entail contributing towards developing our drug delivery capabilities with a focus on complex chemically synthesized modalities. This person will be working collaboratively with discovery and development partners across disciplines to improve delivery of these modalities and advance molecules to clinical development with improved developability profiles. The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on developability, preclinical and/or clinical formulation, biopharmaceutics, and drug delivery concepts relevant to small molecules and peptides

Qualifications

• Senior Scientist I typically requires Bachelors, Masters, or Ph.D. with 10+ (B.S.), 8+ (M.S.), and 1-3 (Ph.D.) years of experience in pharmaceutical or related industry. Preferred educational backgrounds include but are not restricted to Pharmaceutical Sciences, Pharmaceutical Engineering, Chemical/ Biomedical Engineering, and Materials Science.
• Fundamental understanding of biopharmaceutics as it relates to drug absorption across routes of administration including biorelevant dissolution testing, ex vivo permeability assessment, and peptide aggregation.
• Familiarity and preferred hands-on experience in physicochemical property assessment related to understanding CMC developability profile and potential risk mitigation strategies. Techniques of interest include, but are not limited to: chromatography, DSF, rat intestinal perfusion, Ussing Chambers, Franz Diffusion cells, X-ray diffraction, thermal analysis, microscopy, biophysical characterization techniques, etc.
• Experience developing and characterizing drug delivery systems to improve the bioperformance of peptides, in particular the use of permeation enhancer formulations.
• Experience supporting GLP toxicology studies for oral peptide development.
• Knowledge of preclinical and clinical formulation development principles relevant to chemically synthesized molecules across routes of administration.
• Excellent self-management and organizational skills.
• Demonstrated strong communication skills and ability to clearly communicate theories and concepts, influence others without authority, and drive technical excellence.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, and determinable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Companys soleandabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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https://www.abbvie.com/join-us/reasonable-accommodations.html