Sr. Scientist, Electrochemical and Microarray DNA Synthesis

AtlasBase; South San Francisco (CA); On-site; USD 125,000 - 150,000; Full time

Job summary

AtlasBase in South San Francisco is seeking a Sr. Scientist, Electrochemical and Microarray DNA Synthesis to lead CMOS chip-based DNA synthesis workflows and electrochemical synthesis protocol development.

You will collaborate with engineering and synthesis teams to build prototype testbeds, integrating chemistry, fluidics and hardware systems. The role requires an advanced degree in chemistry or a closely related field, hands-on experience with oligonucleotide synthesis and NGS workflows, plus

Qualifications

• Advanced degree (PhD) in Chemistry, Organic Chemistry, Chemical Engineering, or related field.
• MS/BS with significant relevant experience considered.
• Experience in biotech or pharma R&D is highly desirable.
• Proven track record in phosphoramidite oligonucleotide synthesis chemistry and platform development.
• Experience in oligonucleotide microarray or pool synthesis is highly desirable.
• Strong understanding of DNA chip technologies and synthetic biology applications.
• Hands-on experience with NGS workflows and data analysis is desirable.
• Familiarity with scripting for synthesis automation.
• Ability to collaborate cross-functionally across R&D and manufacturing.

Responsibilities

• Develop and optimize CMOS chip-based DNA synthesis workflows.
• Develop and optimize electrochemical synthesis protocols and integration.
• Refine surface functionalization strategies to improve synthesis efficiency.
• Collaborate with engineering and synthesis teams on prototype testbeds.
• Operate NGS-based analytical pipelines for quality assessment.
• Analyze experimental data with molecular biology and chemistry techniques.
• Drive tech transfer from R&D to manufacturing with scale-up documentation.
• Define and execute scientific objectives aligned with company goals.
• Present plans, results, and next steps in meetings.
• Maintain meticulous records of all experimental work.

Skills

DNA synthesis

Oligonucleotide synthesis

Phosphoramidite chemistry

NGS workflows

Automation scripting

Cross-functional collaboration

Project management

Laboratory techniques

Education

PhD in Chemistry or related field

MS/BS with significant relevant experience

Tools

NGS workflows

Synthesis automation scripting

Job description

About AtlasBase

AtlasBase is a fast-growing pioneer in Molecular Computing, bridging the gap between traditional IT and biotechnology. We are redefining global IT infrastructure by driving breakthroughs in both Molecular Compute and Molecular Data Storage. By commercializing synthetic DNA-based technologies at IT scale, AtlasBase delivers ultra-high-density, low-maintenance, and carbon-conscious solutions built for the explosive growth and value of the world's data. Leveraging nature’s most durable medium, we provide a virtually permanent foundation that transforms how the world processes and secures its most critical information.

About AtlasBase

AtlasBase is a fast-growing pioneer in Molecular Computing, bridging the gap between traditional IT and biotechnology. We are redefining global IT infrastructure by driving breakthroughs in both Molecular Compute and Molecular Data Storage. By commercializing synthetic DNA-based technologies at IT scale, AtlasBase delivers ultra-high-density, low-maintenance, and carbon-conscious solutions built for the explosive growth and value of the world's data. Leveraging nature’s most durable medium, we provide a virtually permanent foundation that transforms how the world processes and secures its most critical information.

Originally spun out of Twist Bioscience, our team is an elite fusion of scientists, engineers, and operators dedicated to solving some of the most complex infrastructure challenges on Earth. While our work is grounded in deep science, our success depends on world-class talent across every discipline. We are seeking a Sr. Scientist, Electrochemical and Microarray DNA Synthesis who is ready to bring their expertise to a high-impact environment and help us build a brand-new category of technology.

Essential Duties And Responsibilities

• Major contributor to the development and optimization of CMOS chip-based DNA synthesis workflows, including both phosphoramidite and enzymatic chemistries
• Develop and optimize electrochemical synthesis protocols, including chip handling, hardware configuration and software integration, and process troubleshooting
• Investigate and refine surface functionalization strategies to improve synthesis efficiency and fidelity
• Collaborate with engineering and synthesis teams to build and iterate prototype testbeds, integrating chemistry, fluidics, and hardware systems
• Operate NGS-based analytical pipelines for quality assessment of oligonucleotide pools
• Analyze experimental data using molecular biology and organic chemistry techniques
• Drive technology transfer from R&D to manufacturing, ensuring robust scale-up and process documentation
• Help define and execute scientific and technical objectives aligned with company goals
• Present experimental plans, results, conclusions, and next steps at group meetings, project team meetings, and company-wide meetings.
• Maintain detailed and meticulous records of all experimental work and analysis.

Qualifications

• Qualified candidates will have an advanced degree (PhD) in Chemistry, Organic Chemistry, Chemical Engineering, or a closely related field.
• Experienced MS or BS candidates with significant relevant experience will also be considered.
• Experience in a biotech or pharma R&D environment is highly desirable.
• Proven track record and proficiency in phosphoramidite oligonucleotide synthesis chemistry and platform development
• Experience in oligonucleotide microarray or pool synthesis is highly desirable
• Strong understanding of DNA chip technologies and synthetic biology applications
• Hands-on experience with NGS workflows and data analysis is highly desirable
• Familiarity with software scripting for synthesis automation
• Demonstrated ability to participate cross-functional projects and collaborate across R&D and manufacturing teams
• Excellent problem-solving, communication, and project management skills

Physical Demands & Work Environment

• Work will be performed onsite in office and laboratory space located in South San Francisco.
• Mobility: Must be able to move about the laboratory and office environment regularly. This includes standing and walking for extended periods, often up to 6–8 hours per day.
• Manual Dexterity: Must have fine motor skills and steady hands to handle delicate instruments, operate laboratory equipment, pipette accurately, and perform repetitive benchwork with precision.
• Lifting/Carrying: Must be able to lift and carry up to 40 pounds occasionally, such as boxes of lab supplies or equipment.
• Visual Acuity: Must have sufficient visual acuity to read small print on labels, instrument displays, and computer monitors. Close vision, color vision, and the ability to adjust focus are required.
• Environmental Conditions: Frequently exposed to typical laboratory conditions, including biological samples, chemicals, and reagents. Must be able to wear appropriate personal protective equipment (PPE) such as lab coats, gloves, and safety goggles as required.

The Pay Range For This Role Is

125,000 - 150,000 USD per year(HQ)