Sr. Scientist, Assay Development Services

Promega; Madison (WI); On-site; USD 120,000 - 165,000; Full time

Job summary

Promega Corporation seeks a PhD-level scientist to support pharma/biotech customers with Promega-enabled assays and cell line development across target engagement, PPI, metabolism, and targeted protein degradation. You will provide scientific leadership and troubleshoot projects in a dynamic team.

You will work on bench-based experiments, miniaturize assays for HTS, and collaborate with program managers and sales to deliver results while embracing AI tools to improve efficiency and

Qualifications

• PhD in a scientific discipline with 2–5 years of postgraduate experience in drug discovery programs or industrial R&D.
• Proficient with automation equipment; familiarity with assay development in small titer format, HTS, validation/counterscreening, and assay transfer is a plus.
• Proficient with Microsoft applications and graphing software.
• Quick to adopt emerging technologies, including AI, to improve efficiency and collaboration.

Responsibilities

• Work at the bench to perform experiments using mammalian cell culture, transfections, cloning, CRISPR, immunoblotting, and flow cytometry to develop luminescence-based assays.
• Miniaturize and validate developed assays to enable high-throughput screening using lab automation.
• Own projects from kickoff to delivery with independent experimental design and timelines.
• Communicate project status and results through client meetings and detailed technical reports.
• Work on several different types of projects at a time.
• Leverage AI and advanced digital tools to accelerate experimental design, optimize assay development strategies, enhance data analysis and decision-making.
• Collaborate with program managers, sales, and other business leaders on project execution.
• Demonstrate inclusion and maintain a safe workspace; act with kindness, curiosity, and respect.
• Embrace Promega's ESI core principles in daily work.
• Understand and comply with ethical, legal, and regulatory requirements applicable to our business.

Skills

AI adoption

Automation equipment

Microsoft applications

Scientific leadership

Education

PhD in a scientific discipline

Tools

Automation equipment

Microsoft applications

Job description

OUR TEAM:

We, Tailored Research and Development Solutions (TRS), are a small group of enthusiastic scientists within Life Sciences with backgrounds from multiple disciplines. We foster a learning and collaborative environment while focusing on serving our Pharma/Biotech customers in areas including assay development using Promega's innovative and cutting-edge technologies. We work closely with R&D to enable Promega clients.

YOUR ROLE:

The TRS team works in multiple areas such as target engagement, targeted protein degradation, metabolism, cell health, and protein-protein interaction. You will receive the necessary training and be expected to act as a technical expert in multiple areas of specialization, to apply scientific knowledge to individual projects, and to execute and champion innovative projects.

JOB OBJECTIVE:

Support Pharma/Biotech customers in drug discovery by providing Promega-enabled assay and cell line development in areas like target engagement, protein-protein interaction, metabolism, and targeted protein degradation. Act as a technical expert in multiple areas of specialization. Apply scientific leadership, project management, and troubleshooting to individual projects.

CORE DUTIES:

• 1. Work at the bench to perform experiments using a wide variety of molecular and cellular biology techniques including, but not limited to, mammalian cell culture, transfections, molecular cloning, CRISPR, immunoblotting, and flow cytometry to develop luminescence-based protein-protein interaction assays, target engagement assays, targeted protein degradation assays, metabolism assays, and immunoassays.
• 2. Miniaturize and validate developed assays to enable high-throughput screening using lab automation equipment.
• 3. Take ownership of projects from kickoff to delivery, including independent experimental design and execution while maintaining timelines.
• 4. Communicate project status and results through regular client meetings and detailed technical project reports.
• 5. Work on several different types of projects at a time.
• 6. Leverage artificial intelligence and advanced digital tools to accelerate experimental design, optimize assay development strategies, enhance data analysis, and improve scientific efficiency and decision-making.
• 7. Collaborate with program managers, sales, and other business leaders on project execution.
• 8. Demonstrate inclusion through words and actions and be accountable for a safe workspace. Act with kindness, curiosity, and respect for others.
• 9. Embrace and be open to incorporating Promega's 6 Emotional & Social Intelligence (ESI) core principles in daily work.
• 10. Understand and comply with ethical, legal, and regulatory requirements applicable to our business.

KEY QUALIFICATIONS:

• 1. PhD in a scientific discipline with 2-5 years of postgraduate experience in drug discovery programs or industrial R&D.
• 2. Proficient with automation equipment; familiarity with assay development in small titer format, high-throughput screening, validation/counterscreening, and assay transfer workflows is a plus.
• 3. Proficient with Microsoft applications and graphing software.
• 4. Quick to adopt emerging technologies, including AI, to improve efficiency and cross-functional collaboration.

PHYSICAL DEMANDS:

• 1. Ability to work at a lab bench or fume hood for extended periods.
• 2. Ability to wear protective gear (gloves, lab coat, safety glasses, etc.).
• 3. Ability to operate a computer.

At Promega, we are committed to building a diverse workforce that reflects the communities we serve and creating a culture where everyone belongs. As an Equal Opportunity Employer, we welcome and encourage applications from all backgrounds, ensuring that employment decisions are made fairly and equitably.