Sr Scientist, Analytical Sciences

Genetix Biotherapeutics; Boston (MA); On-site; USD 127,000 - 164,000; Full time

Benefits offered by this job

Health insurance

401(k) with employer match

Paid time off and holidays

Tuition reimbursement & loan repayment

Job summary

Genetix Biotherapeutics is seeking a Senior Scientist, Analytical Sciences to provide hands-on technical leadership in analytical development for our gene therapy portfolio. The role designs and executes internal testing for process development and leads transfer of methods to external QC labs, acting as the SME for comparability studies and investigations.

The ideal candidate has deep CGT analytics experience, a track record of assay troubleshooting and tech transfers, and the rigor to bridge

Qualifications

• Ph.D. in Biochemistry, Molecular Biology, Analytical Chemistry, or related field with 2–5 years in biopharma; or M.S. with 6+ years of experience.
• Deep hands-on mastery of CGT analytical techniques (Flow Cytometry, ddPCR/qPCR, Cell‑based Potency assays, ELISA).
• Experience with CD34+ cell lineages and/or viral vector characterization preferred.
• Proven success in developing, optimizing, and transferring assays to external CDMOs/CROs; strong troubleshooting skills.
• Excellent communication of bench data to cross-functional teams.

Responsibilities

• Lead analytical execution to support project milestones and pipeline progression.
• Develop and implement analytical strategies aligned with development milestones and regulatory guidelines.
• Partner with Process Development for rapid, high-quality testing for optimization and comparability studies.
• Transfer analytical methods to external QC laboratories; author transfer protocols and oversee validation.
• Support troubleshooting, OOS/OOT investigations, and root-cause analyses with CDMO/CRO partners.
• Collaborate across CMC to produce reports, SOPs, and data packages for regulatory submissions.

Skills

Flow Cytometry

qPCR/ddPCR

Cell-based Potency Assays

ELISA

CD34+ Cells

Viral Vector Characterization

Education

Ph.D. in Biochemistry or Molecular Biology or Analytical Chemistry

M.S. in related field with 6+ years industry experience

Tools

qPCR instruments

Flow cytometers

ELISA readers

Job description

About Genetix Biotherapeutics At Genetix Biotherapeutics every role has meaning, every team member is respected, and every day is a chance to make a difference. When you join Genetix, you're not just landing a new role, you become part of a company that's pursuing curative gene therapies to give patients and their families more days. We are doers, thinkers and collaborators who embrace and live by our values:

About Genetix Biotherapeutics At Genetix Biotherapeutics every role has meaning, every team member is respected, and every day is a chance to make a difference. When you join Genetix, you're not just landing a new role, you become part of a company that pursuing curative gene therapies to give patients and their families more days. We are doers, thinkers and collaborators who embrace and live by our values: Our innovation is rooted in the diversity of our teams and results are achieved through cooperation and the integration of multiple viewpoints. This is personal and we approach every challenge with radical care.

Sr. Scientist, Analytical Sciences

At Genetix Biotherapeutics every role has meaning, every team member is respected, and every day is a chance to make a difference. When you join Genetix, you're not just landing a new role, you become part of a company that pursuing curative gene therapies to give patients and their families more days. We are doers, thinkers and collaborators who embrace and live by our values: Our innovation is rooted in the diversity of our teams and results are achieved through cooperation and the integration of multiple viewpoints. This is personal and we approach every challenge with radical care.

SUMMARY

The Senior Scientist, Analytical Sciences will provide strong hands-on technical leadership from the bench for the internal analytical development functions supporting our company’s gene therapy product portfolio. This individual contributor role will be responsible for designing and executing internal analytical testing for process development, innovating and qualifying new analytical assays, and leading the end-to-end technical transfer of these methods to external QC laboratories. The role will serve as a primary technical resource for process comparability studies and external investigations, partnering closely cross-functionally within Technical Development and across Technical Operations. The ideal candidate will bring deep hands-on expertise in cell and gene therapy (CGT) analytical development, a proven track record of successful assay troubleshooting and tech transfers, and the scientific rigor required to bridge the gap between early scientific assay development and commercial QC operations. This is a full-time position requiring a strong on-site laboratory presence in our Somerville office/laboratory.

RESPONSIBILITIES

Analytical Execution & Support

• Execute and manage analytical workflows internally to support day-to-day project milestones and pipeline progression.
• Implement analytical strategies within the lab to ensure tight alignment with process development milestones and regulatory guidelines.
• Partner closely with Process Development to provide rapid, high-quality analytical testing for process optimization, routine characterization, and comparability studies.
• Contribute to the life cycle management of analytical control strategies by identifying, troubleshooting, and proposing assay updates or modern replacements.
• Provide the technical rigor and execute the characterization assays needed to support strategic, data-driven decisions for process comparability.

Assay Development & Innovation

• Lead from the bench in the design, development, qualification, and routine testing of novel analytical assays.
• Drive innovation in analytical platforms to improve assay sensitivity, throughput, and robustness, specifically tailored for complex cell therapies, including the implementation of bench-top automation.
• Develop new methods with a "right first time" mentality to ensure seamless, robust transition to a downstream GMP environment.

Tech Transfer & Technical Investigations

• Serve as the primary technical lead for the successful transfer of analytical methods from the internal development bench to external QC testing laboratories.
• Author method transfer protocols and oversee the technical execution of method validation at external sites, ensuring compliance with regulatory standards.
• Act as the technical subject matter expert (SME) to support troubleshooting, OOS/OOT investigations, and root-cause analyses with external CDMO/CRO partners.

Cross-Functional Leadership & Compliance

• Collaborate across the CMC team to author and review technical reports, SOPs, and analytical data packages supporting regulatory submissions (IND/BLA).
• Serve as a technical anchor in the laboratory, leading by example with high standards of strict scientific rigor and operational excellence.
• Manage personal laboratory resource allocation, instrument maintenance, and testing timelines to ensure seamless program delivery.

QUALIFICATIONS

• Education: Ph.D. in Biochemistry, Molecular Biology, Analytical Chemistry, or a related scientific discipline with 2–5 years of biopharmaceutical industry experience; or an M.S. with 6+ years of relevant industry experience.
• Technical Expertise: Deep, hands‑on mastery of cell and gene therapy analytical techniques (e.g., Multicolor Flow Cytometry, ddPCR/qPCR, Cell‑based Potency assays, ELISA). Prior hands‑on experience with CD34+ cell lineages and/or viral vector characterization is highly preferred.
• Track Record: Proven success in developing, optimizing, and transferring assays to external CDMOs/CROs, as well as authoring technical reports used in regulatory filings. Strong troubleshooting capability for complex biological assays is essential.
• Communication: Exceptional verbal and written communication skills, with the ability to clearly translate complex, bench‑level analytical data into actionable insights for cross‑functional CMC teams.

Additional InformationThe pay transparency range provided below is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. We may ultimately pay more or less than the posted range, and the range may be modified in the future. This role is eligible for an annual bonus and long‑term incentive. Actual base salary pay will be based on several factors, including but not limited to experience, skills, relevant education/qualifications, external market, internal equity, and other job‑related factors permitted by law.

Genetix’s total rewards package also provides employees with a comprehensive and competitive benefits suite to support a variety of employee needs. These benefits include comprehensive health, life and disability insurance, employer‑matched 401(k) plan, lifestyle spending account, flexible time‑off + paid holidays and winter holiday period, tuition reimbursement & loan repayment assistance, paid parental leave, paid onsite parking, commuter subsidy, and much more.

Pay Transparency: $127,000 USD - $164,000 USD

Genetix is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.