Sr. Research Associate -Systems Integration

Sarmal

San Diego, Northern (CA, KY)

Hybrid

USD 72,000 - 85,000

Full time

14 days+

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Benefits offered by this job

Medical coverage

Dental coverage

Vision coverage

Company-paid life insurance

401(k) retirement plan

Generous paid time off

Voluntary benefits

Job summary

Sarmal, Inc. is a San Diego–based biotechnology company seeking a Senior Research Associate to drive systems integration for our molecular diagnostics platform. You will bridge molecular biology and engineering to transition bench processes onto an automated instrument platform and consumables.

You will lead integration testing, design studies for consumables, and troubleshoot flow cell and fluidic systems while collaborating with assay development, chemistry, and device engineering teams.

Qualifications

BS/MS in Biomedical Engineering, Chemical Engineering, Bioengineering, Molecular Biology, Chemistry, or related field with 5+ years industry experience
Experience with early prototype systems and iterative design cycles
Hands-on experience with consumable characterization and root-cause analysis
Experience with fluorescence imaging/spectroscopy instrumentation
Experience with fluidic/flow cell based systems and GMP/ISO 13485 environments
Molecular biology techniques relevant to nucleic acid diagnostics

Responsibilities

Build, characterize, and iterate on early prototype instrument and consumable systems with cross-functional teams
Lead integration testing, risk analysis, and troubleshooting across development cycles
Design studies to characterize consumable performance across lots and iterations
Support fluidic and flow cell based system troubleshooting and design improvements
Operate fluorescence-based detection systems and evaluate performance metrics
Translate bench-scale processes into integrated, system-compatible workflows
Define and execute integration testing protocols spanning fluids, electronics, and chemistry
Maintain documentation suitable for DHF/design control and regulatory submissions
Collaborate with quality/regulatory to align with GMP/FDA design controls
Contribute to design-for-manufacturability and –reliability discussions

Skills

Biomedical engineering

Molecular biology

Fluorescence imaging

Regulated environment

DOE/statistical analysis

Documentation

Education

BS/MS in relevant field

Tools

Flow cell systems

Imaging instruments

Job description

Company Overview

Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights.
We are a highly collaborative, R&D-driven teamoperatingin a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications.
AtSarmal, we value scientific rigor, curiosity, and a buildermindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality.

About the Job

We are seeking a Senior Research Associate to drive systems integration efforts for our molecular diagnostics platform. This role sits at the interface of molecular biology and engineering and is responsible for the transition and optimization of molecular and biochemical processes onto automated sample-to-answer molecular diagnostic instrument platform and consumable.

Key Responsibilities

Build, characterize, and iterate on early prototype instrument and consumable systems, working closely with engineering, assay development, and chemistry teams.
Lead integration testing, risk analysis, and troubleshooting across development cycles.
Design and execute studies to characterize consumable performance (e.g.,flowcell fluidics, reagent cartridges, sample prep modules) across manufacturing lots and design iterations.
Support development and troubleshooting of fluidic and flow cell–based systems, including flow path design, priming/wetting behavior, bubble management, dead volume, and flow uniformity.
Operate and troubleshoot fluorescence-based detection systems (imaging or plate-reader based), evaluating performance using metrics such as signal intensity, background, specificity, sensitivity, and reproducibility.
Translate bench-scale sample preparation, molecular processes and detection chemistries into integrated, system-compatible workflows.
Define and execute integration testing protocols spanning fluidics, electronics/instrumentation, and assay chemistry to identify failure modes and performance bottlenecks.
Generate and maintain rigorous documentation (protocols, data records, technical reports) suitable for design history files and regulatory submissions.
Collaborate with quality and regulatory functions to ensure development work aligns with GMP/ISO/FDA design control requirements as the program advances toward verification and validation.
Contribute to design-for-manufacturability and design-for-reliability discussions for consumable and instrument subsystems.
Collaborate cross-functionally with Assay Development, Reagent Chemistry, Device/Instrument Engineering, Manufacturing, and Quality/Regulatory teams to transition surface chemistry processes from R&D through pilot scale-up and into IVD manufacturing under design control.
Design and execute DOEs to optimize coating uniformity, reproducibility, shelf-life/stability, and lot-to-lot consistency; support root cause investigations and CAPAs related to surface chemistry performance.
Author and maintain technical reports, protocols, batch records, DHF/design control documentation, and contribute to regulatory submissions (e.g., FDA 510(k)/PMA, CE-IVDR) as needed.
Support IP strategy, including invention disclosures and patent support.
Present data and recommendations to cross-functional project teams and leadership.

Qualifications

Required Qualifications

BS/MS in Biomedical Engineering, Chemical Engineering, Bioengineering, Molecular Biology, Chemistry, or related field, with 5+ years of relevant industry experience (or equivalent combination of education and experience)
Demonstrated experience in product development with early prototype systems — comfortable working with immature hardware, ambiguous specs, and iterative design cycles
Hands-on experience with consumable characterization — designing test methods, defining acceptance criteria, and driving root-cause analysis on consumable performance issues
Hands-on experience with fluorescence imaging and/or fluorescence spectroscopy instrumentation, including image/data analysis for signal characterization
Experience working with fluidic and/or flow cell–based systems (microfluidics, cartridge-based systems, or similar) — understanding of flow behavior, fluid handling, and common failure modes
Experience working in a regulated environment (GMP, ISO 13485, FDA design controls) with familiarity in documentation practices supporting design history files and quality systems
Working knowledge of molecular biology techniques relevant to nucleic acid-based diagnostics (nucleic acid extraction/purification, PCR or isothermal amplification, sample preparation workflows)
Strong hands-on laboratory skills, meticulous record-keeping, and the ability to troubleshoot systematically across chemistry, biology, and hardware domains
Excellent written and verbal communication skills; ability to synthesize data into clear reports for cross-functional audiences.

Preferred Qualifications

Experience with in vitro diagnostics (IVD) product development, particularly molecule diagnostics or point-of-care platforms.
Experience with automated liquid-handling systems is a plus
Familiarity with whole blood sample handling, including cell lysis, nucleic acid depletion/enrichment strategies, or blood-based sample stabilization/cryopreservation.
Experience supporting verification and validation (V&V) activities or transfer to manufacturing.
Statistical data analysis skills (e.g., JMP, Minitab, Python/R) for characterization and DOE studies.

Education

BS/MS in Biomedical Engineering, Chemical Engineering, Bioengineering, Molecular Biology, Chemistry, or related field, with 5+ years of relevant industry experience (or equivalent combination of education and experience)

Benefits & Perks

Sarmal offers a competitive and comprehensive benefits package, including:

Medical, dental, and vision coverage
Company-paid life insurance
401(k) retirement plan
Generous paid time off
Access to additional voluntary benefits, employee perks, and discount programs
We are committed to supporting the well-being of our employees and providing a strong foundation for both professional and personal success.

$72,000 - $85,000 a year

California Pay Transparency Statement

The anticipated salary range for this position is $72,000 – $85,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations.

EEO Statement

Sarmal is an equal opportunity employer committed to building a diverse and inclusive workplace. We do not discriminate based on race, color, religion, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran status, or any other characteristic protected by applicable federal, state, or local laws.

Reasonable Accommodation Statement

Sarmal is an equal opportunity employer that values diversity and inclusion. We welcome applicants of all backgrounds and consider all qualified candidates in accordance with applicable laws.

Closing Statement

Join us in advancing the next generation of genomic technologies and shaping the future of precision health.

Why Join Sarmal