Sr. Research Associate, Molecular Biology

BioSpace; San Diego (CA); On-site; USD 110,000 - 150,000; Full time

Job summary

BioSpace is seeking a Senior Research Associate to advance cell therapy programs through independent execution of complex research activities, including translational and molecular biology workflows. You will analyze data, troubleshoot challenges, and contribute to planning and method development with R&D teams.

The role requires experience in next-generation sequencing, biomarker assays, and data interpretation, with the ability to communicate findings to cross-functional groups and maintain

Qualifications

• Bachelor’s degree in biology or biochemistry or related field.
• Minimum 3 years molecular biology experience in a lab setting.
• Hands-on experience with next-generation sequencing workflows.
• Experience with single-cell or single-nucleus RNA sequencing preferred.
• LC-MS sample preparation experience preferred.

Responsibilities

• Independently execute and optimize scRNA-seq workflows, including sample prep and library QC.
• Perform molecular biology workflows: nucleic acid isolation, PCR/qPCR, sequencing prep.
• Support cell culture and translational research activities with R&D teams.
• Analyze and interpret experimental data; communicate findings to supervisors.

Skills

Single-cell RNA sequencing

Data analysis

Python

R

Education

Bachelor’s degree in biology or related field

Tools

PCR/qPCR

LC-MS techniques

Job description

The Senior Research Associate independently executes complex research and development activities supporting the development and characterization of the company’s cell therapy programs. Working with minimal supervision, this role performs and optimizes translational and molecular biology workflows, analyzes and interprets experimental data, troubleshoots technical challenges, and contributes to experimental planning and method development. The position collaborates with R&D and cross-functional teams and serves as a technical resource in support of project and research objectives.

Duties And Responsibilities

• Independently execute and optimize single cell and single nucleus RNA sequencing workflows, including cell thawing and counting, sample preparation, library preparation, library quality control, and preparation of libraries for sequencing.
• Execute molecular biology and biomarker assay workflows including nucleic acid isolation, PCR, qPCR, sequencing related assays, and sample preparation and processing for LC-MS based analyses.
• Support cell culture workflows and perform other research and development activities in collaboration with R&D scientists and cross-functional partners.
• Make detailed observations; compile, analyze, and interpret experimental and sequencing data; assess data quality; summarize conclusions; and communicate findings to supervisors and the broader R&D team.
• Independently troubleshoot technical issues involving experimental design, assay execution, sequencing workflows, instrumentation, and data quality; recommend and implement solutions within established project objectives.
• Contribute to experimental planning, assay optimization, quality-control strategy, and method development to meet evolving project and translational research needs.
• Evaluate, develop, optimize, and implement new methods, assays, and technologies to advance assigned projects and platform capabilities.
• Independently maintain complete, accurate, and audit-ready laboratory notebooks, experimental records, protocols, and data documentation in accordance with applicable quality and documentation requirements.
• Prepare figures, data summaries, protocols, technical reports, and other documentation for internal reviews, project discussions, and knowledge sharing.
• Maintain laboratory organization and the readiness of equipment, reagents, consumables, and general laboratory supplies.
• Serve as a technical resource within areas of expertise and support training, knowledge sharing, and laboratory best practices.
• Maintain current knowledge of relevant scientific literature, translational research methods, sequencing technologies, biomarker applications, and emerging industry practices while complying with applicable safety, training, and quality requirements.
• May participate in scientific conferences and contribute to scientific publications, internal presentations, or other scientific communications, as appropriate.

Education And Experience

• Bachelor’s degree in biology, biochemistry or related disciplines is required.
• A minimum of 3 years of relevant experience in molecular biology or a related laboratory setting is preferred; or equivalent and relevant combination of education and experience.
• Hands-on experience with next-generation sequencing workflows, including sample preparation, library preparation, library quality control, and sequencing-readiness activities.
• Experience with single-cell or single-nucleus RNA sequencing is strongly preferred.
• Experience with molecular biology and translational assay workflows, including nucleic acid isolation, PCR/qPCR, biomarker analysis, biological sample processing, and preparation for downstream analyses. Experience with LC-MS sample preparation is preferred.

Job Specifications

• Technical Proficiency: Strong molecular and cell biology laboratory skills and a solid understanding of scientific principles, with the ability to independently execute and optimize workflows.
• Analytical Skills: Strong analytical, quantitative, and problem-solving skills, with the ability to assess data quality, interpret experimental results, troubleshoot technical issues, and draw appropriate conclusions.
• Data Analysis & Presentation: Ability to efficiently organize, analyze, interpret, and present experimental and sequencing data to scientific and cross-functional audiences.
• Communication Skills: Strong verbal and written communication skills, with the ability to clearly document procedures and results, communicate scientific findings, and collaborate effectively across teams.
• Organization & Documentation: Excellent organizational skills with demonstrated ability to maintain thorough, accurate experimental records, laboratory notebooks, protocols, and supporting documentation.
• Collaboration & Adaptability: Ability to work effectively in cross-functional and team-based environments, adapt to changing project priorities, and share technical knowledge and best practices with colleagues.
• Professional Scientific Expertise: Maintains current knowledge of relevant scientific literature, technologies, and industry best practices while complying with applicable safety, training, and quality requirements.
• Technology & Computational Skills: Proficiency with Microsoft Office applications and familiarity with data analysis tools or programming languages such as R, Python, or Bash.
• Flexibility: Willingness to work flexible hours, including occasional weekends, as needed to support experiments, sample processing, sequencing runs, or project timelines.

WORKING CONDITIONS

Office and Lab environment. While performing the duties of this Job, the employee is frequently exposed to toxic or caustic chemicals. This is an indoor position requiring the ability to perform experiments in the laboratory, and type and use a computer.

PHYSICAL DEMANDS

While performing the duties of this Job, the employee is Regularly required to stand; walk; sit; use hands to finger, handle, or feel; reach with hands and arms and talk or hear. The employee must occasionally lift and/or move up to 10 pounds. Specific vision abilities required by this job include close vision, distance vision, color vision, peripheral vision, depth perception and ability to adjust focus. These work environment characteristics are representative of the environment the job holder will encounter. Reasonable accommodation may be made to enable people with disabilities to perform the essential functions of the job.