Sr Imaging Scientist

Intuitive Surgical, Inc. in

Sunnyvale (CA)

On-site

USD 158,000 - 268,000

Full time

3 days ago

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Job summary

Intuitive Surgical, Inc. in Sunnyvale, CA, is seeking a Sr Imaging Scientist to lead the scientific foundation of fluorescence imaging programs, bridging clinical studies and imaging systems across registrational programs.

The role emphasizes translating endpoints into defensible study designs and aligning detection performance with clinical data. The successful candidate will oversee imaging system characterization, collaborate with cross-functional teams, and contribute to regulatory

Qualifications

PhD in biomedical optics, medical imaging, biomedical engineering, electrical engineering, medical physics, or a related field.

Responsibilities

Define primary, key secondary, and exploratory endpoints for imaging agent trials, and develop the clinical and literature justification supporting their performance thresholds.
Partner with pathologists, surgeons, and investigators on the interpretation of imaging data by having a solid understanding of surgical, radiologic, and pathologic workflows.
Develop study operations manuals focused on correlative analysis between intraoperative imaging and histopathology, including specimen mapping and the criteria by which fluorescence signal is matched to pathologic outcome.
Develop imaging charters and fluorescence assessment procedures, establishing objective protocol-defined read criteria and a defensible reference standard.
Oversee blinded independent central image review and reader agreement analyses, and lead scientific review of imaging data infrastructure, including database design, eCRF build, and data quality ahead of database lock.
Author imaging content for protocols, statistical analysis plans, briefing books, and clinical study reports, and maintain consistency of imaging and endpoint definitions across submission documents.
Translate health authority feedback into study design and documentation, and assess the applicability of regulatory guidance and precedent approvals to imaging agent programs.
Design and execute bench and phantom studies establishing limit of detection, linearity, and reproducibility, and develop tissue-mimicking models and fluorophore standards.

Skills

Biomedical imaging

Drug development

Imaging data analysis

Python

MATLAB

Regulatory understanding

Education

PhD in biomedical optics / medical imaging / biomedical engineering

Tools

Python

MATLAB

Job description

Sr Imaging Scientist (Finance)

Company Description: It started with a simple idea: what if surgery could be less invasive and recovery less painful? Nearly 30 years later, that question still fuels everything we do at Intuitive. As a global leader in robotic-assisted surgery and minimally invasive care, our technologies-like the da Vinci surgical system and Ion-have transformed how care is delivered for millions of patients worldwide.

We're a team of engineers, clinicians, and innovators united by one purpose: to make surgery smarter, safer, and more human. Every day, our work helps care teams perform with greater precision and patients recover faster, improving outcomes around the world.

The problems we solve demand creativity, rigor, and collaboration. The work is challenging, but deeply meaningful‑because every improvement we make has the potential to change a life.

If you're ready to contribute to something bigger than yourself and help transform the future of healthcare, you'll find your purpose here.

Job Description

Primary Function of Position

The Sr. Scientist, Imaging Science is responsible for the technical and scientific foundation of Intuitive's fluorescence imaging programs, spanning the clinical studies that establish agent performance and the imaging systems that deliver it. The position is accountable for maintaining alignment between the detection performance established through system characterization and the performance measured in clinical study.

The position requires depth across the full breadth of imaging science, from the definition and justification of clinical endpoints through the test methodology used to characterize imaging system and agent performance. Clinical development sits at the center of the position, bridging in two directions: toward Regulatory Affairs, where endpoints and imaging methodology must be defensible to health authorities, and toward Engineering, where the imaging systems of the future must resolve the imaging agents of today. The successful candidate will be equally effective in both. Near‑term emphasis is on the scientific basis of Intuitive's registrational programs. As those study designs are finalized, responsibilities transition toward agent‑device compatibility across current and future Intuitive platforms, ecosystem development, and computational tooling. The Principal Scientist partners with Clinical Development, Biostatistics, Regulatory Affairs, Imaging Systems Engineering, Software, Data Management, and external collaborators.

Roles and Responsibilities

Clinical Study Design and Imaging Data Interpretation

Define primary, key secondary, and exploratory endpoints for imaging agent trials, and develop the clinical and literature justification supporting their performance thresholds.
Partner with pathologists, surgeons, and investigators on the interpretation of imaging data by having a solid understanding of surgical, radiologic, and pathologic workflows.
Develop study operations manuals focused on correlative analysis between intraoperative imaging and histopathology, including specimen mapping and the criteria by which fluorescence signal is matched to pathologic outcome.
Develop imaging charters and fluorescence assessment procedures, establishing objective protocol‑defined read criteria and a defensible reference standard.
Oversee blinded independent central image review and reader agreement analyses, and lead scientific review of imaging data infrastructure, including database design, eCRF build, and data quality ahead of database lock.

Regulatory Strategy and Submissions

Author imaging content for protocols, statistical analysis plans, briefing books, and clinical study reports, and maintain consistency of imaging and endpoint definitions across submission documents.
Prepare technical content for health authority meetings and submissions, and contribute to responses to Agency questions and information requests.
Translate health authority feedback into study design and documentation, and assess the applicability of regulatory guidance and precedent approvals to imaging agent programs.

Imaging Systems and Agent Performance

Characterize agent performance on Intuitive platforms, including excitation and emission spectral matching, camera sensitivity, working distance, depth of detection, and signal‑to‑background ratio under clinically representative conditions.
Design and execute bench and phantom studies establishing limit of detection, linearity, and reproducibility, and develop the tissue‑mimicking models and fluorophore standards those studies require.
Partner with Engineering and external collaborators on illumination, optical filter selection, sensor configuration, and display rendering, and define imaging system requirements for future platforms so next‑generation systems can detect our agents.
Work with Software Engineering on image processing and visualization algorithms, and assess how software and firmware changes affect agent detection and the clinical interpretation of fluorescence.
Develop engineering test methods, protocols, and acceptance criteria, and contribute to design inputs, verification and validation, and design control documentation for agent‑device combinations.
Develop computational and machine learning approaches that accelerate image analysis, system characterization, and development timelines.

Qualifications

PhD in biomedical optics, medical imaging, biomedical engineering, electrical engineering, medical physics, or a related field.
Minimum 5 years of drug development experience, including direct contribution to programs advancing through clinical development toward regulatory submission.
Demonstrated depth in optical or molecular imaging, including quantitative evaluation of detection performance against histopathology or an equivalent reference standard.
Hands‑on experience characterizing imaging system performance, including phantom design, spectral measurement, and sensitivity or limit‑of‑detection testing.
Experience contributing to the design of clinical studies of imaging products, including endpoint definition and diagnostic performance measures.
Proficiency in diagnostic accuracy methodology, including sensitivity, specificity, predictive values, reference standard design, verification bias, and reader variability, together with the ability to critically review a statistical analysis plan.
Experience supporting regulatory activities, including authoring technical content for health authority submissions and meeting materials.
Working knowledge of the therapeutic and surgical context in which the agent is used, sufficient to evaluate whether a proposed endpoint is clinically meaningful.

Preferred Qualifications

Drug development experience overlapping with imaging hardware or device development.
Experience with fluorescence‑guided surgery, near‑infrared imaging, or endoscopic and robotic imaging platforms.
Familiarity with design controls and verification and validation processes.
Proficiency in Python, MATLAB, or equivalent for image analysis, and experience applying machine learning to medical image data.
Experience developing products in urologic oncology, urology, and/or genitourinary pathology therapeutic areas. Experience with prostatectomy preferred.

Additional Information

Due to the nature of our business and the role, please note that Intuitive and/or your customer(s) may require that you show current proof of vaccination against certain diseases including COVID‑19. Details can vary by role.

Intuitive is an Equal Opportunity Employer

We provide equal employment opportunities to all qualified applicants and employees, and prohibit discrimination and harassment of any type, without regard to race, sex, pregnancy, sexual orientation, gender identity, national origin, color, age, religion, protected veteran or disability status, genetic information or any other status protected under federal, state, or local applicable laws.

Mandatory Notices

U.S. Export Controls Disclaimer: In accordance with the U.S. Export Administration Regulations (15 CFR §743.13(b)), some roles at Intuitive Surgical may be subject to U.S. export controls for prospective employees who are nationals from countries currently on embargo or sanctions status.

Certain information you provide as part of the application will be used for purposes of determining whether Intuitive Surgical will need to (i) obtain an export license from the U.S. Government on your behalf (note: the government's licensing process can take 3 to 6+ months) or (ii) implement a Technology Control Plan (“TCP”) (note: typically adds 2 weeks to the hiring process).

For any Intuitive role subject to export controls, final offers are contingent upon obtaining an approved export license and/or an executed TCP prior to the prospective employee's start date, which may or may not be flexible, and within a timeframe that does not unreasonably impede the hiring need. If applicable, candidates will be notified and instructed on any requirements for these purposes.

We will consider for employment qualified applicants with arrest and conviction records in accordance with fair chance laws.

Preference will be given to qualified candidates who do not reside, or plan to reside, in Alabama, Arkansas, Delaware, Florida, Indiana, Iowa, Louisiana, Maryland, Mississippi, Missouri, Oklahoma, Pennsylvania, South Carolina, or Tennessee.

This position may be filled at a different job level than listed here depending on business need and/or on the selected candidate's experience, knowledge and skills.

Accommodation & Accessibility Notice

Intuitive is committed to providing reasonable accommodations to qualified individuals with disabilities. If you require assistance or an accommodation during any part of the application or interview process, please contact People Services at [email protected].

We provide market-competitive compensation packages, inclusive of base pay, incentives, benefits, and equity. It would not be typical for someone to be hired at the top end of range for the role, as actual pay will be determined based on several factors, including experience, skills, and qualifications. The target compensation ranges are listed.