Sr Director/Executive Director, Pharm Science Technical Lead

BridgeBio Pharma; San Francisco (CA); Hybrid; USD 267,000 - 332,000; Full time

Benefits offered by this job

Market-leading compensation

401(k) with employer match

Employee Stock Purchase Program (ESPP)

Hybrid work model

Health insurance for you and dependen

Job summary

BridgeBio Pharma in San Francisco seeks a Sr Director/Executive Director, Pharmaceutical Sciences Technical Lead to drive CMC strategy across clinical and commercial programs. You will lead cross-functional teams in formulation, analytical development, process development, manufacturing, tech transfer, and regulatory submissions in a fast-paced, matrixed environment.

The role requires a PhD or equivalent and 15+ years in pharma/biotech with leadership in Pharmaceutical Sciences/CMC, plus proven

Qualifications

• PhD or equivalent in Pharmaceutical Sciences or related field.

Responsibilities

• Lead Pharmaceutical Sciences teams across multiple functional disciplines.
• Establish priorities, resource plans, and development goals aligned with corporate objectives.
• Identify program risks and implement mitigation strategies to maintain timelines and deliverables.
• Provide scientific leadership for formulation development, analytical development, process development, manufacturing, and technology transfer.
• Partner with Regulatory, Clinical, and Commercial to align on development priorities and execution.
• Represent Pharmaceutical Sciences in governance committees and executive reviews.
• Influence senior leadership decisions through data-driven scientific and operational recommendations.

Skills

Leadership

Strategy

Pharmaceutical Development

Regulatory Affairs

Team Building

Vendor Management

Education

PhD in Pharmaceutical Sciences

Job description

Sr Director/Executive Director, Pharm Science Technical Lead

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allowsscience and small teams of experts to lead the way. We build bridges to groundbreaking advancements in raredisease, anddevelop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we’llask"why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.

What You’ll Do

The Pharmaceutical Sciences Team Lead (PSTL) is a senior scientific and strategic leadership role responsible for advancing pharmaceutical development and CMC (Chemistry, Manufacturing, and Controls) strategy across clinical and commercial-stage programs. This individual will lead cross-functional pharmaceutical sciences activities spanning formulation development, analytical development, process development, manufacturing, technology transfer, regulatory submissions, and lifecycle management. The role requires a proven leader with deep expertise in pharmaceutical development, strong regulatory and quality knowledge, and the ability to lead high-performing scientific teams in a fast-paced, matrixed environment. The PSTL will serve as a key contributor to corporate development strategy and represent Pharmaceutical Sciences in executive governance, regulatory interactions, and external partnerships.

Responsibilities

• Lead high-performing, collaborative, and accountable Pharmaceutical Sciences teams across multiple functional disciplines.
• Establish and drive organizational priorities, resource plans, and development goals aligned with corporate objectives.
• Identify program risks proactively and implement mitigation strategies to maintain timelines and deliverables.
• Provide scientific leadership for formulation development, analytical development, process development, manufacturing, and technology transfer.
• Partner with Non-clinical, Clinical, Regulatory, and Commercial organizations to ensure alignment on development priorities and execution.
• Represent Pharmaceutical Sciences in governance committees and executive reviews.
• Influence senior leadership decisions through data-driven scientific and operational recommendations.
• Collaborate with Regulatory Sciences and Regulatory Affairs on CMC strategy, risk mitigation, and agency responses.
• Represent Pharmaceutical Sciences in interactions with global health authorities and regulatory inspections, as needed.
• Participate in due diligence activities, external scientific collaborations, and business development evaluations.
• Build strong relationships with external partners, vendors, and industry organizations.
• Implement scalable systems, processes, and metrics to improve development efficiency and execution quality.
• Foster an inclusive and performance-oriented culture that embodies company leadership values and behaviors.

Where You’ll Work

This role requires in-office collaboration 2-3x per week in our San Francisco Office and travel, as needed

Who You Are

• PhD or equivalent advanced degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, Biochemistry, or related scientific discipline preferred.
• 15+ years of progressive pharmaceutical or biotechnology industry experience, including significant leadership responsibility in Pharmaceutical Sciences, CMC, or Technical Operations.
• Experience leading multidisciplinary scientific teams in matrixed global organizations.
• Strong knowledge of pharmaceutical development, manufacturing, analytical development, regulatory expectations, and quality systems.
• Experience managing external manufacturing and development partners (CMOs/CDMOs/CROs).
• Strategic thinker with strong scientific and operational acumen.
• Exceptional communication and influencing skills with executive presence.
• Proven ability to drive alignment across complex cross-functional organizations.
• Strong decision-making and problem-solving capabilities in dynamic development environments.
• Prior experience in NDA/MAA submissions and regulatory approvals.
• Experience supporting commercial manufacturing and lifecycle management activities.
• Familiarity with global supply chain strategy and technical operations.
• Experience in both large pharmaceutical and emerging biotech environments preferred.
• Travel, as needed

At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.

$267,000 - $331,900 USD

As a global company, our comprehensive benefits may vary based on location. We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return.

For BridgeBio Full-Time U.S Based Roles:

• Market-leading compensation
• 401(k) with employer match
• Employee Stock Purchase Program (ESPP)
• Pre-tax commuter benefits (transit and parking)
• Referral bonus for hired candidates
• Subsidized lunch and parking on in-office days
• 100% employer-paid medical, dental, and vision premiums for you and your dependents
• HealthSavings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA)
• Fertility & family-forming benefits
• Expanded mental health support (therapy and coaching resources)
• Hybrid work model with flexibility
• Flexible, “take-what-you-need” paid time off and company-paid holidays
• Comprehensive paid medical and parental leave to care for yourself and your family

Skill Development & Career Paths:

• People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility
• We provide career pathing through regular feedback, continuouseducationand professional development programs via LinkedIn Learning,LifeLabs, &BetterUpCoaching
• We celebratestrong performancewith financial rewards, peer-to-peer recognition, and growth opportunities