Sr. Director, Analytical Development CMC - Global Analytics

Centessa; Boston, Northern (MA, KY); Hybrid; USD 165,000 - 250,000; Full time

Benefits offered by this job

401(k) plan

Medical insurance

Dental insurance

Vision insurance

Life insurance

Paid time off

Wellness program

Job summary

Centessa Pharmaceuticals, a Boston-based clinical-stage company, seeks a Senior Director of Analytical Development in the CMC group to drive method development, validation, and strategic testing across programs. The role requires hands-on development for drug substances and product forms, including oversight of external CDMOs.

This senior leadership position reports to the Executive Director and emphasizes cross-functional collaboration, regulatory alignment, and timely data delivery to support

Qualifications

• Advanced degree in chemistry, pharmaceutical sciences, or related field (PhD strongly preferred).
• 10+ years of small molecule pharmaceutical industry experience.
• Deep expertise in cGMP and regulatory requirements for pharmaceutical products.

Responsibilities

• Lead analytical strategy related to phase-appropriate method development, validation, and product characterization for multiple programs.
• Collaboratively work in a team environment to lead drug substance and drug product analytical development activities at third-party vendors.
• Review method validation protocol and reports, and test data for release, stability, and characterization.
• Save and store documentation, generate stability result tables, file stability data for expiry and shelf-life assignments.
• Lead specification settings based upon batch history and supporting analytical data.

Skills

Analytical method development

CDMO management

cGMP regulatory knowledge

Project leadership

Education

PhD in Chemistry or related field

Job description

Centessa Pharmaceuticals, a Boston-based clinical-stage company, seeks a Senior Director of Analytical Development in the CMC group to drive method development, validation, and strategic testing across programs. The role requires hands-on development for drug substances and product forms, including oversight of external CDMOs.

This senior leadership position reports to the Executive Director and emphasizes cross-functional collaboration, regulatory alignment, and timely data delivery to support