Sr. Bioengineer, Preclinical Development (In Vivo)

Pulse Biosciences, Inc.; Hayward (CA); On-site; USD 135,000 - 155,000; Full time

Job summary

Pulse Biosciences, Inc. in Hayward, CA seeks a Sr. Bioengineer of Preclinical Development to execute complex preclinical studies, develop models, and support CellFX platform efforts.

You will mentor staff, collaborate with Clinical, Regulatory, and Engineering teams, troubleshoot issues, and contribute to data-driven design decisions.

Required: Bachelor’s with 5+ years or Master’s with 3+ years in bioengineering or related field; travel up to 25%; onsite in the Bay Area.

Qualifications

• Bachelor’s Degree with 5+ years of experience or Master’s Degree 3+ years in Bioengineering, Biomedical Engineering, Biology, or related field.
• Strong understanding of anatomy, imaging, surgical workflows, tissue processing, and histology.
• Experience with energy-based delivery systems is preferred.
• Experience supporting preclinical or translational research required.
• Startup experience preferred.
• Proficient knowledge and skill in Microsoft Office Suite applications.
• Strong analytical, problem-solving, and experimental design skills.
• Strong communication skills, including technical writing and data presentation.
• Ability to independently execute complex preclinical studies.
• Ability to manage multiple priorities in a dynamic environment.
• Ability to travel up to 25% of the time.
• Ability to lift 25 pounds.

Responsibilities

• Lead execution of preclinical studies, including protocol development, experimental design input, data collection, and report authorship.
• Develop and refine benchtop, ex vivo, and in vivo models to support engineering and scientific objectives.
• Troubleshoot technical issues related to devices, instrumentation, and experimental workflows.
• Analyze engineering and biological data to generate insights that inform product development.
• Support design engineers with device testing, verification activities, and treatment parameter optimization.
• Maintain and improve histology and tissue-processing workflows; ensure data integrity and traceability.
• Mentor Associate and Engineer-level staff in laboratory techniques, data analysis, and documentation.
• Collaborate with Clinical, Regulatory, and Engineering teams to support evidence generation for regulatory submissions and clinical programs.
• Prepare technical presentations and documentation for internal and external stakeholders.
• Manage vendor relationships related to histology, imaging, and preclinical services.
• Mentor junior staff and contribute to team development.

Skills

Experimental design

Data analysis

Scientific writing

Communication

Education

Bachelor’s degree in Bioengineering or related field

Master’s degree in Bioengineering or related field

Tools

Microsoft Office Suite

Job description

Pulse Biosciences (Nasdaq: PLSE): Join the Future of Bioelectric Medicine

Pulse Biosciences is a novel bioelectric medicine company committed to health innovation that has the potential to improve the quality of life for patients. The Company’s proprietary CellFX® nsPFA™ (nanosecond Pulsed Field Ablation) technology delivers nanosecond pulses of electrical energy to non-thermally ablate cells while sparing adjacent noncellular tissue.

The Company is actively pursuing the development of its CellFX nsPFA technology for use in the surgical treatment of atrial fibrillation and percutaneously in a select few other markets where it could have a profound positive impact on healthcare for both patients and providers. Visit pulsebiosciences.com to learn more.

Why Join Us?

At Pulse Biosciences, we are driven by purpose and innovation.

• Our Mission: To build a viable Company that designs, produces, and commercializes nano-pulse technology to improve and extend the lives of patients. To solve the needs of patients, physicians, and healthcare providers with high quality and high reliability products and services, developed in accordance with rigorous scientific, engineering, and clinical standards. We exist to make a positive difference in the lives of patients, physicians, healthcare providers, shareholders and our Pulse Biosciences team members.
• Our Culture: A community of creative, forward-thinking individuals tackling challenges with ingenuity and collaboration.
• Our Commitment: Hiring the best and brightest minds to advance our world-class organization.

What You Will Experience

• Culture and Purpose - Purposeful and rewarding work collaborating with bright and curious minds brings us together!
• Innovative Environment - An environment that fosters innovation to take products from concept to human use quickly!
• Growth Opportunities - Learning culture focusing on professional and personal growth and development that you can only get in a startup-like environment!
• Comprehensive Benefits - A variety of health insurance plans and supplemental insurance options, and 401k retirement savings plan.
• Ownership and Rewards - Stock options awards and Employee Stock Purchase Plan (ESPP) to share in our success.
• Work-Life Balance - Enjoy paid time off, paid holidays, flexible work schedule and wellness program, including onsite gym and mindfulness classes.
• Diversity & Inclusion - A commitment to providing a respectful work environment to our diverse workforce.

About The Role

The Sr. Bioengineer of Preclinical Development is a key technical contributor responsible for independently executing complex preclinical studies, developing experimental models, and supporting engineering and scientific initiatives that advance the CellFX® nsPFA platform. This role leads portions of preclinical programs, troubleshoots technical challenges, and provides engineering insight that informs device design, treatment algorithms, and clinical strategy. This role mentors junior staff, supports cross‑functional teams, and contributes to the generation of high‑quality scientific and engineering evidence.

To Make An Impact, You Will

• Lead execution of preclinical studies, including protocol development, experimental design input, data collection, and report authorship.
• Develop and refine benchtop, ex vivo, and in vivo models to support engineering and scientific objectives.
• Troubleshoot technical issues related to devices, instrumentation, and experimental workflows.
• Analyze engineering and biological data to generate insights that inform product development.
• Support design engineers with device testing, verification activities, and treatment parameter optimization.
• Maintain and improve histology and tissue‑processing workflows; ensure data integrity and traceability.
• Mentor Associate and Engineer‑level staff in laboratory techniques, data analysis, and documentation.
• Collaborate with Clinical, Regulatory, and Engineering teams to support evidence generation for regulatory submissions and clinical programs.
• Prepare technical presentations and documentation for internal and external stakeholders.
• Manage vendor relationships related to histology, imaging, and preclinical services.
• Mentor junior staff and contribute to team development.

To Excel, You Will Bring

• Bachelor’s Degree with 5+ years of experience or Master’s Degree 3+ years of experience in Bioengineering, Biomedical Engineering, Biology, or related field.
• Strong understanding of anatomy, imaging, surgical workflows, tissue processing, and histology.
• Experience with energy‑based delivery systems is preferred.
• Experience supporting preclinical or translational research required.
• Startup experience preferred.
• Proficient knowledge and skill in Microsoft Office Suite applications.
• Strong analytical, problem‑solving, and experimental design skills.
• Strong communication skills, including technical writing and data presentation.
• Ability to independently execute complex preclinical studies.
• Ability to manage multiple priorities in a dynamic environment.
• Ability to independently execute complex preclinical studies.
• Ability to work as a team member, multi-task and be very flexible to adapt to the ever-changing work priorities and requirements of a dynamic, fast growing company.
• Ability to travel up to 25% of the time, including overnight travel may be required.
• Ability to lift 25 pounds.

Pay Range

Compensation is determined based on a wide range of factors including location, job-related skills, experience, education, and training. It is not typical for an individual to be hired at or near the top of the range for their role. This pay range is specific to Northern California location. Base salary range: $135K-$155K. This position is located onsite in Hayward, CA and candidates must reside in the San Francisco Bay Area. No relocation offered.

We provide equal employment opportunities (EEO) to all persons regardless of race, age, color, gender, sexual orientation, national origin, physical or mental disability, religion, or any other characteristic protected by federal, state or local law. We will make reasonable accommodations for qualified individuals with disabilities.