Sr Associate Scientist, Histology

BioSpace; Village of Tarrytown (NY); On-site; USD 80,000 - 131,000; Full time

Job summary

Regeneron is seeking a Sr. Associate Scientist to join the Obesity, Metabolism and Muscle Diseases Group in Tarrytown, NY.

This onsite role provides expert tissue processing and staining services across multiple programs, managing end-to-end histology workflows and delivering high-quality data on time. You will lead IHC/IF development, optimize protocols, and collaborate with teams to advance gene expression localization, image acquisition, and quantitative analysis.

Qualifications

• BS with 5+ years or MS with 2+ years of relevant experience.
• Proficiency in standard and special histochemical staining techniques across multiple tissue types.
• Demonstrated IHC/IF assay development, optimization, and troubleshooting experience.
• Proficiency with whole-slide imaging systems and digital pathology image analysis software (HALO).
• Strong organizational and record-keeping skills, with the ability to manage multiple stakeholders.
• Excellent oral and written communication skills.
• Preferred: RNAscope/BaseScope/FISH experience.

Responsibilities

• Process tissue samples from multiple tissue types (liver, heart, brain, muscle, adipose) including fixation, dehydration, embedding and sectioning.
• Perform routine and special histological staining according to program needs.
• Conduct IHC and IF, developing, optimizing and validating new protocols, antibody titrations, and antigen retrieval conditions.
• Apply ISH/RNAscope techniques for gene expression localization when required.
• Perform image acquisition using scanning platforms and manage image data repositories.
• Perform quantitative image analysis and develop/apply custom algorithms as needed.
• Generate high-quality figures and data summaries for internal reports and publications.
• Maintain and communicate a dynamic workload tracker, flagging capacity constraints to stakeholders.

Skills

Histology

IHC/IF development

Whole-slide imaging

HALO software

Tissue processing

Data management

Communication

Education

BS in Life Sciences

MS in Life Sciences

Tools

HALO

Job description

Build Our Future Together

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Sr. Associate Scientist to join our Obesity, Metabolism and Muscle Diseases Group, serving as a central histological resource providing expert tissue processing and staining services across multiple research programs simultaneously. In this role, you will manage end-to-end histological workflows spanning a broad range of tissue types, maintaining rigorous quality standards while navigating competing program demands to deliver high-quality data on time.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & Where

Location: Tarrytown, NY

Work model/flexibility: Onsite

Discover Your Role

• Process tissue samples from multiple tissue types (e.g., liver, heart, brain, muscle, adipose), including fixation, dehydration, clearing, embedding, and sectioning
• Perform routine and special histological staining according to program needs
• Conduct IHC and IF, developing, optimizing, and validating new protocols, antibody titrations, and antigen retrieval conditions
• Apply in situ hybridization (ISH/RNAscope) techniques for gene expression localization where required
• Perform image acquisition using various scanning platforms and manage image data repositories
• Perform quantitative image analysis, developing and applying customized algorithms as needed
• Generate high-quality figures and data summaries for internal reports, regulatory packages, and peer-reviewed publications
• Maintain and communicate a dynamic workload tracker, proactively flagging capacity constraints or scheduling conflicts to stakeholders

This Role Requires

• BS with 5+ years or MS with 2+ years of relevant experience
• Proficiency in standard and special histochemical staining techniques across multiple tissue types
• Demonstrated IHC/IF assay development, optimization, and troubleshooting experience
• Proficiency with whole-slide imaging systems and digital pathology image analysis software (e.g., HALO)
• Strong organizational and record-keeping skills, with the ability to manage and prioritize simultaneous requests from multiple stakeholders
• Excellent oral and written communication skills
• Preferred: experience with in situ hybridization platforms (RNAscope, BaseScope, FISH)

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

We disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed onsite.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually) $80,300.00 - $131,100.00