Sr. Associate Scientist

Pfizer Inc; Bothell (WA); Presencial; USD 69.000 - 114.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Relocation assistance may be available

Comprehensive benefits package

On-site work environment

Descripción de la vacante

Pfizer is seeking a Senior Associate Scientist (R2) in Upstream Process Development to develop robust, scalable manufacturing processes for recombinant proteins for clinical trials. The role involves bench-scale experiments, scale-down models, and collaboration with pilot and GMP facilities.

Responsibilities include technology transfer, data documentation in ELNs, supporting regulatory submissions, and working in a collaborative team with occasional weekend work.

Formación

• Bachelor's degree with 3 years' industrial experience or Master's degree with 0-2 years experience in Chemical / Biochemical Engineering, Cell Biology, Biotechnology, Biomedical Engineering or a relevant field.
• Relevant research experience in a laboratory setting is required.
• Ability to grasp scientific concepts, interpret complex data, and formulate new hypothesis.
• Competency in aseptic laboratory technique and the ability to design and carry out complex experiments and interpret data.
• Demonstrated effectiveness in collaborative projects, and ability to communicate effectively with scientists and management in a highly matrixed organization.

Responsabilidades

• Design and execute experiments in appropriate scale-down models such as shake flasks and bioreactors in an effort to develop robust, high yield, and scalable manufacturing processes
• Serve as upstream technical lead; ensure accurate technology transfer to pilot and GMP manufacturing facilities; provide technical support during manufacturing campaign as needed
• Timely and accurately document data in electronic lab notebooks; author technical reports and contribute to relevant sections of regulatory submissions such as IND and BLA
• Participate and contribute to discussions in lab and project team meetings on design of experiments and interpretation of data
• Contribute to safe, efficient, and harmonious lab environment; strong lab citizen and collaborative team player
• Occasionally work over the weekend to passage flasks, sample bioreactors or perform other essential tasks

Conocimientos

Scientific analysis

Aseptic technique

Collaborative teamwork

Communication

Data interpretation

Python programming

Educación

Bachelor's degree in Chemical/Biochemical Engineering, Cell Biology, Biotechnology, Biomedical Engineering or related field

Master's degree in related field

Herramientas

Ambr15

Ambr250

Python

Descripción del empleo

What You Will Achieve

A Senior Associate Scientist (R2) position is available in the Upstream Process Development group within the Bioprocess R&D organization. The successful applicant will join a team of scientists and engineers focused on developing and optimizing manufacturing processes for recombinant proteins and other modalities for early- and late-phase human clinical trials. In this role, the candidate will be responsible for designing and executing laboratory experiments in bench-top bioreactors and associated scale-down equipment with the goal of developing robust, scalable, and high productivity processes.

The work will also involve working with pilot, clinical, and commercial production facilities to ensure accurate technology transfer, successful large-scale production and associated regulatory filing activities. The candidate may also be involved in cutting edge technology development projects that seek to improve production processes and control strategies leveraging various process analytical technologies.

How You Will Achieve It

• Design and execute experiments in appropriate scale-down models such as shake flasks and bioreactors in an effort to develop robust, high yield, and scalable manufacturing processes
• Serve as upstream technical lead; ensure accurate technology transfer to pilot and GMP manufacturing facilities; provide technical support during manufacturing campaign as needed
• Timely and accurately document data in electronic lab notebooks; author technical reports and contribute to relevant sections of regulatory submissions such as IND and BLA
• Participate and contribute to discussions in lab and project team meetings on design of experiments and interpretation of data
• Contribute to safe, efficient, and harmonious lab environment; strong lab citizen and collaborative team player
• Occasionally work over the weekend to passage flasks, sample bioreactors or perform other essential tasks

QUALIFICATIONS

Must Have

• Bachelor's degree with 3 years' industrial experience or Master's degree with 0-2 years experience in Chemical / Biochemical Engineering, Cell Biology, Biotechnology, Biomedical Engineering or a relevant field
• Relevant research experience in a laboratory setting is required.
• Ability to grasp scientific concepts, interpret complex data, and formulate new hypothesis.
• Competency in aseptic laboratory technique and the ability to design and carry out complex experiments and interpret data.
• Demonstrated effectiveness in collaborative projects, and ability to communicate effectively with scientists and management in a highly matrixed organization.

Nice To Have

• Hands-on experience with high-throughput bioreactor platforms, including ambr15 and ambr250 systems
• Expertise in fed-batch / perfusion bioreactor operations, including process setup, control, troubleshooting, and scale-up of mammalian cell culture processes
• Proficiency in process modeling and multivariate data analysis for process characterization, and predictive process understanding
• Experience with Python programming, workflow automation, or app development to create tools that improve experimental planning, data analysis, visualization, and knowledge-sharing for process development scientists

PHYSICAL/MENTAL REQUIREMENTS

Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• May require occasional work on the weekend for essential tasks
• May need to travel occasionally to attend internal meetings or external conferences

Other Job Details

• Work Location Assignment: On Premise
• The annual base salary for this position ranges from $68,600.00 to $114,300.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
• Relocation assistance may be available based on business needs and/or eligibility.
• Candidates must be authorized to be employed in the U.S. by any employer.
• U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.