Sr Assoc Scientist, Intact Mass (Analytical and Biological Mass Spectrometry)

Regeneron Pharmaceuticals; Tarrytown (GA); On-site; USD 80,000 - 131,000; Full time

Benefits offered by this job

Student Loan Paydown program

Tuition Reimbursement

Family Care Benefits

Relocation Assistance

Inclusion, Culture and Well-Being

Job summary

Regeneron Pharmaceuticals in Tarrytown, NY, is seeking a Sr. Associate Scientist to join the ABMS group. You will develop and apply LC-MS–based analytical methods to characterize monoclonal antibodies and therapeutic protein candidates across R&D programs, and support regulatory submissions with analytical data.

The role requires strong LC-MS skills, experience with protein therapeutics, and collaboration across cross-functional teams in a fast-paced, on-site lab environment.

Qualifications

• Must have a Master’s degree with at least 3 years of relevant experience or a Bachelor’s degree with at least 6 years of relevant experience in Chemistry, Biochemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related field.
• Industrial or academic experience in analytical characterization of protein therapeutics, bioconjugates, or other therapeutic modalities.
• Strong knowledge of and hands-on experience with LC-MS-based characterization of proteins, peptides, and antibody-drug conjugates, including sample preparation, liquid chromatography, mass spectrometry, and data analysis.
• Enjoy developing and troubleshooting analytical methods and solving complex scientific and technical problems.

Responsibilities

• Develop and apply LC-MS-based analytical methods to characterize mAbs and other therapeutic protein candidates across R&D programs.
• Perform sample preparation, LC-MS experiments, and data analysis using relevant software and bioinformatics tools to characterize product quality attributes; document results in ELN entries, presentations, and reports.
• Support process development, R&D activities, and regulatory submissions through analytical characterization and scientific problem-solving.
• Collaborate with cross-functional teams to understand analytical needs, coordinate samples and study activities, and align priorities, timelines, and deliverables.
• Interpret and communicate scientific results through project and group meetings, technical reports, regulatory documents, internal and external conferences, and peer-reviewed publications.
• Plan and prioritize work, manage and visualize data, and deliver clear, timely updates.

Skills

LC-MS characterization

Protein therapeutics analysis

Data analysis

Sample preparation

Education

Master's degree with 3+ years

Bachelor's degree with 6+ years

Tools

Orbitrap

Q-TOF

Triple quadrupole

Xcalibur

Protein Metrics

ChemDraw

Skyline

Proteome Discoverer

Job description

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a highly motivated Sr. Associate Scientist to join the Intact Mass, proteomics technologies and key MS platforms team within the Analytical and Biological Mass Spectrometry (ABMS) Group. In this role, you will develop and apply LC-MS-based analytical methods to advance Regeneron’s pipeline across all stages of development, including antibodies (monospecific, bispecific, and alternative formats), antibody-drug conjugates (ADCs), and other emerging modalities (AAVs, siRNA). You will apply state-of-the-art mass spectrometry and analytical technologies to characterize therapeutic protein candidates, with a focus on critical quality attributes and process development, while collaborating closely with cross-functional teams to coordinate samples, study activities, priorities, and timelines.

This position offers the opportunity to contribute to a fast-growing, science-driven organization that is making a meaningful difference for patients worldwide.

When & where:

• Shift Requirements: Full-time
• Location: On-site in Tarrytown, NY

What you’ll do:

• Develop and apply LC-MS-based analytical methods to characterize mAbs and other therapeutic protein candidates across R&D programs

• Perform sample preparation, LC-MS experiments, and data analysis using relevant software and bioinformatics tools to characterize product quality attributes; document results in electronic laboratory notebook (ELN) entries, presentations, and reports

• Support process development, R&D activities, and regulatory submissions through analytical characterization and scientific problem-solving

• Collaborate with cross-functional teams to understand analytical needs, coordinate samples and study activities, and align priorities, timelines, and deliverables

• Interpret and communicate scientific results through project and group meetings, technical reports, regulatory documents, internal and external conferences, and peer-reviewed publications

• Plan and prioritize work, manage and visualize data, and deliver clear, timely updates

The environment and physical rhythms of this role:

• This is an innovative, fast-paced, and collaborative R&D laboratory environment that calls for results-driven, highly organized, and adaptable scientists with scientific curiosity and the ability to learn new technologies.

• Strong cross-functional collaboration and communication skills are required, including the ability to build productive working relationships and to coordinate samples, activities, priorities, timelines, and deliverables across multiple programs.

Let’s find out if we’re a fit:

Must-haves:

• Master’s degree with at least 3 years of relevant experience, or a Bachelor’s degree with at least 6 years of relevant experience, in Chemistry, Biochemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related field

• Industrial or academic experience in analytical characterization of protein therapeutics, bioconjugates, or other therapeutic modalities

• Strong knowledge of and hands-on experience with LC-MS-based characterization of proteins, peptides, and antibody-drug conjugates, including sample preparation, liquid chromatography, mass spectrometry, and data analysis

• Enjoy developing and troubleshooting analytical methods and solving complex scientific and technical problems

Preferred / nice-to-haves:

• Experience with advanced mass spectrometer platforms (e.g., Orbitrap, Q-TOF, and triple quadrupole), liquid chromatography, and relevant data processing software (e.g., Xcalibur, Protein Metrics, ChemDraw, Skyline, Proteome Discoverer, and other related analytical tools)

Thrive today. Grow tomorrow.

• Student Loan Paydown program & Tuition Reimbursement

• Family Care Benefits

• Relocation Assistance

• Inclusion, Culture and Well-Being programs (including physical & mental health)

Does this sound like you? We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$80,300.00 - $131,100.00