Specialty Sales Representative – Cardiometabolic Rare Disease

Arrowhead Pharmaceuticals; Springfield (MO); On-site; USD 160,000 - 180,000; Full time

Benefits offered by this job

Equity (RSUs)

Car allowance

Health benefits

Job summary

Arrowhead Pharmaceuticals is seeking experienced Specialty Sales Representatives to support the launch and growth of our cardiometabolic portfolio, including siRNA therapies. You will drive prescriber activation, adoption, and sustained utilization through data-driven territory plans and strategic engagement with cardiologists, lipid specialists, endocrinologists and PCPs.

Role requires 5+ years of pharma sales, experience with IDNs or complex systems, and 30% travel.

Qualifications

• Bachelor's degree or equivalent experience; minimum 5 years of pharmaceutical sales experience.
• 3+ years in specialty, rare disease, or cardiovascular therapeutic areas strongly preferred.
• Experience working within integrated delivery networks (IDNs) or complex healthcare systems preferred.
• Demonstrated success launching or expanding complex therapies requiring access navigation and clinical depth.

Responsibilities

• Develop and execute comprehensive territory business plans aligned to brand strategy and launch objectives.
• Deliver clinically accurate product education within approved labeling and articulate complex data to cardiologists, lipid specialists, endocrinologists, and PCPs.
• Build and sustain relationships with healthcare professionals and institutional stakeholders; navigate IDNs with KBMs.
• Collaborate with Marketing, Medical Affairs, Market Access, Health IT, and Patient Services to align territory execution with enterprise strategy.
• Maintain compliant field activity documentation and timely CRM reporting.
• Travel ~30% to represent Arrowhead at meetings and conferences.

Skills

Territory planning

Account management

Data-driven selling

Clinical data communication

Presentation skills

Relationship building

Launch execution

Strategic thinking

Education

Bachelor's degree or equivalent

Job description

Description

Arrowhead Pharmaceuticals is seeking experienced, high-performing, and driven Specialty Sales Representatives to join our expanding commercial organization. This is a unique opportunity to play a meaningful role in the launch and growth of our cardiometabolic portfolio, including Plozasiran (siRNA targeting APOC3), developed for patients with rare and high-need cardiovascular conditions such as Familial Chylomicronemia Syndrome (FCS) and Severe Hypertriglyceridemia (SHTG). This role is critical to delivering launch excellence by driving prescriber activation, accelerating therapy adoption, and ensuring sustained utilization within complex healthcare environments. The Specialty Sales Representative will operate with strategic agility, strong clinical acumen, and disciplined execution to positively impact patient outcomes.

About Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

Key Responsibilities

Territory & Strategic Business Planning

• Develop and execute comprehensive, data-driven territory business plans aligned to brand strategy and launch objectives.
• Analyze territory data (prescribing trends, account potential, access landscape) to identify growth opportunities and prioritize high-value targets.
• Manage territory budget responsibly, including speaker programs and promotional initiatives.
• Consistently achieve or exceed sales goals and performance metrics.

Prescriber Activation & Clinical Engagement

• Deliver compelling, compliant, and clinically accurate product education within approved labeling.
• Articulate complex clinical data and value propositions tailored to cardiologists, lipid specialists, endocrinologists, and targeted PCPs.
• Differentiate Arrowhead therapies within a competitive and evolving cardiometabolic landscape.
• Execute speaker programs, educational events, and peer-to-peer engagements to drive awareness and adoption.
• Support appropriate patient identification and therapy initiation through thoughtful provider engagement.

Stakeholder & Account Management

• Build and sustain strong, trust-based relationships with healthcare professionals, office staff, and institutional stakeholders.
• Navigate complex health systems and coordinate effectively within IDNs in partnership with Key Account Managers.
• Identify access barriers and collaborate with Market Access and patient services to support pull-through.
• Maintain consistent, high-quality engagement and service across accounts to drive durable utilization.

Cross-Functional Collaboration

• Partner closely with Marketing, Medical Affairs, Market Access, Health IT, and Patient Services to align territory execution with enterprise strategy.
• Provide actionable field insights regarding market dynamics, competitive activity, and customer feedback.

Compliance & Operational Excellence

• Maintain full compliance with company policies, industry regulations, and promotional standards.
• Accurately document field activity and manage CRM reporting in a timely manner.
• Demonstrate disciplined execution, accountability, and ethical conduct in all engagements.

Travel & Engagement

• Represent Arrowhead at regional and national meetings, training programs, and key conferences (~30% travel required).
• Overnight travel may be necessary depending on territory geography.

Qualifications

Experience

• Bachelor's degree or equivalent experience and minimum 5 years of pharmaceutical sales experience required.
• Demonstrated success launching or expanding complex therapies requiring access navigation and clinical depth required.
• 3+ years in specialty, rare disease, or cardiovascular therapeutic areas strongly preferred.
• Experience working within integrated delivery networks (IDNs) or complex healthcare systems preferred.

Skills & Competencies

• Strong territory planning and account management capabilities with a data-driven mindset.
• Ability to interpret and communicate complex clinical data confidently and credibly.
• Excellent communication, presentation, and relationship-building skills.
• High level of business acumen and ability to identify strategic growth opportunities.
• Resilience, adaptability, and ability to thrive in a fast-paced launch environment.
• Proven track record of achieving or exceeding performance targets.
• Strong organizational skills and ability to manage competing priorities effectively.

Compensation & Benefits

• Competitive base salary: $160,000-$180,000 plus incentive compensation (20-30% target bonus).
• Equity (RSUs) and car allowance program.
• Comprehensive benefits package including health, dental, vision, and 401(k).

Ready to make a difference?

Join us in our mission to bring transformative RNAi therapies to patients with rare cardiovascular conditions.