Small Scale Synthesis, Oligonucleotide Synthesis and Chemistry Co-op (Spring 2027)

Wave Life Sciences USA, Inc.; Lexington (MA); Vor Ort; USD 33.000 - 41.000; Vollzeit

Zusammenfassung

Wave Life Sciences in Lexington, Massachusetts, is seeking a highly motivated co-op student to join its Small Scale Synthesis, Oligonucleotide Synthesis and Chemistry teams. The position offers hands-on training in oligonucleotide synthesis, formulation, purification and analysis within a multidisciplinary biotech environment.

Completion of coursework in organic chemistry is required; biochemistry and analytical chemistry are a plus.

Qualifikationen

• Currently enrolled in an undergraduate science program in Chemistry, Biology, Biotechnology or related field.
• Coursework in organic chemistry is required; biochemistry and analytical chemistry are a plus.
• Understanding of laboratory best practices and safety protocols.
• Attention to detail and well organized.
• Laboratory experience with pipetting, weighing, and centrifugation preferred.
• Enthusiasm for DNA/RNA therapeutic development.

Aufgaben

• Prepare reagents and amidites for oligonucleotide synthesis.
• Learn about solid phase synthesis and operate a Mermade192X synthesizer.
• Purify oligonucleotides by preparative HPLC.
• Analyze oligonucleotides by LC-MS, UV and pH.
• Learn additional instrumentation including lyophilizers, speed vacs, nanodrop and UPLC.
• Gain exposure to the use of an automated liquid handler for high throughput plate-based sample preparation.
• Record and present data in an electronic laboratory notebook (ELN)

Kenntnisse

Undergraduate student

Organic chemistry coursework

Lab safety

Attention to detail

Pipetting

Weighing

Centrifugation

Teamwork

Organization

Ausbildung

Undergraduate science program

Tools

Mermade192X synthesizer

HPLC

LC-MS

UV

pH meter

Lyophilizers

Speed vac

Nanodrop

UPLC

ELN

Jobbeschreibung

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Wave Life Sciences seeks a highly motivated co-op student to join its team of Small Scale Synthesis, Oligonucleotide Synthesis and Chemistry scientists in Lexington, Massachusetts. This co-op student will gain exposure to areas of oligonucleotide synthesis, formulation, purification, and analysis. The co-op will be trained in a variety of laboratory techniques and instrumentation, making this an excellent learning opportunity for future entrance into industry or academia. This is an ideal position for any student with strong organizational skills and attention to detail who thrives in a team-oriented, fast-paced and multi-disciplinary biotech environment. Completion of coursework in organic chemistry required with biochemistry, analytical chemistry and laboratory experience is preferred. This position is well-suited for an individual with an interest in oligonucleotide synthesis who thrives in a team-oriented, fast-paced, biotech environment. This candidate will be responsible for fulfilling oligo requests to support Discovery-related activities and ensuring sample quality.

RESPONSIBILITIES

• Prepare reagents and amidites for oligonucleotide synthesis
• Learn about solid phase synthesis and operate a Mermade192X synthesizer
• Purify oligonucleotides by preparative HPLC
• Analyze oligonucleotides by LC-MS, UV and pH
• Learn additional instrumentation including lyophilizers, speed vacs, nanodrop and UPLC
• Gain exposure to the use of an automated liquid handler for high throughput plate-based sample preparation
• Record and present data in an electronic laboratory notebook (ELN)

QUALIFICATIONS

• Currently enrolled in an undergraduate science programin Chemistry, Biology, Biotechnology or related field
• Coursework in organic chemistry is required, biochemistry and analytical chemistry is a plus
• Understanding of laboratory best practices and safety protocols
• Attention to detail and well organized
• Laboratory experience with common laboratory operations including pipetting, weighing, and centrifugation preferred
• Enthusiasm for DNA/RNA therapeutic development

Pay Range Disclosure Statement

$24—$30 USD

The range provided is based on what we believe is a reasonable estimate for the annual base salary pay range for this position at the time of posting. Actual annual base salary will vary based on several factors including, but not limited to, relevant skills, experience, qualifications, position criticality, and internal equity. This position is eligible for a discretionary annual bonus and discretionary stock-based long-term incentives. In addition to compensation, Wave offers a comprehensive and competitive range of benefits designed to support our employees’ and their families physical and financial health and overall well-being. These include, but are not limited to, company-sponsored medical, dental, vision, life, long and short-term disability insurances, generous paid time off (including a week-long company shutdown in the Summer and the Winter), 401K participation with matching contributions, and Employee Stock Purchase Program.

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.

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