Site Activation Manager

NCBiotech; Durham (NC); On-site; USD 86,000 - 170,000; Full time

Benefits offered by this job

Competitive benefits package

Salary transparency

Pay equity and compliance

Job summary

Worldwide Clinical Trials is seeking a Site Activation Manager to lead activation across oncology studies. You will coordinate cross-functional teams, manage timelines and budgets, and drive quality site activation from feasibility to regulatory readiness.

You will communicate risks, develop plans, and ensure SOP/ICH GCP compliance while supporting business development and proposal input where needed.

Qualifications

• A minimum four-year degree or nursing degree is required.
• Minimum of 4 years CRO experience in Study Start-Up with country lead or manager experience required.
• Proficient in cross-cultural communication and English (spoken and written).

Responsibilities

• Serve as the primary point of accountability for site activation and start-up activities on assigned studies.
• Oversee cross-functional site activation activities to ensure milestones are achieved on time and within budget.
• Manage the accurate tracking, analysis, and reporting of site activation progress and metrics.
• Partner with project teams to support feasibility, site qualification, selection, and regulatory activities as needed.
• Communicate site activation status, risks, and mitigation plans to Sponsors, project leadership, and internal teams.
• Develop and maintain site activation project plans and support risk assessment and issue resolution.
• Ensure site activation activities are appropriately budgeted, with out-of-scope work tracked and managed through change control.
• Drive continuous improvement through SOP development, best practices, metrics, and departmental initiatives.
• Contribute to business development activities, including proposal development and bid defense support.
• Liaise with internal stakeholders and external vendors, escalating issues as needed to ensure on-time delivery.
• Ensure compliance with SOPs, ICH GCP, and applicable regulatory requirements.

Skills

Leadership

Organizational management

Cross-cultural communication

English proficiency

Collaboration

Team-oriented

Regulatory knowledge

Clinical project planning

Initiation & planning

I CH GCP awareness

Education

Bachelor's degree or nursing degree

Tools

MS Office

Job description

Who we are

We’re a global, midsize CRO that pushes boundaries, innovates and invents because the path to a cure for the world’s most persistent diseases is not paved by those who play it safe. It is built by those who take pioneering, creative approaches and implement them with quality and excellence.

We are Worldwide Clinical Trials, and we are a global team of over 3,500+ experts, bright thinkers, dreamers and doers and, together, we are changing the way the world experiences CROs – in the best possible way.

Our mission is to work with passion and purpose every day to improve lives and we are looking for others who value this same pursuit.

Why Worldwide

We believe everyone plays an important role in making a world of difference for patients and their caregivers. From our hands‑on, accessible leaders, to our cohesive and supportive teams, we are committed to enabling professionals from all backgrounds and experiences to succeed. We prioritize cultivating a diverse and inclusive environment that continues to promote collaboration and creativity. We are proud to be a workplace where people thrive by being themselves and are inspired to do their best work every day. Join us!

What the Site Activation Manager does at Worldwide Clinical Trials

The Site Activation Manager is accountable for site activation project management and delivery activities within the Oncology therapeutic area. Responsibilities include coordination, collaboration, and oversight of site identification and central and local ECs (for NA countries only) activities, progression of essential documents collection, monitoring of investigator and site contracts status, and any other country and/or study‑specific site activation tasks necessary for Site Activation in accordance with Good Clinical Practices (GCPs) and applicable local and international regulations and Standard Operating Procedures (SOPs). May also include pre‑award support by providing site activation‑related input into the proposal text and budget items. Reports to a senior member of the Site Activation leadership team within the assigned therapeutic area.

What you will do

• Serve as the primary point of accountability for site activation and start‑up activities on assigned studies.
• Oversee cross‑functional site activation activities to ensure milestones are achieved on time and within budget.
• Manage the accurate tracking, analysis, and reporting of site activation progress and metrics.
• Partner with project teams to support feasibility, site qualification, selection, and regulatory activities as needed.
• Communicate site activation status, risks, and mitigation plans to Sponsors, project leadership, and internal teams.
• Develop and maintain site activation project plans and support risk assessment and issue resolution.
• Ensure site activation activities are appropriately budgeted, with out‑of‑scope work tracked and managed through change control.
• Drive continuous improvement through SOP development, best practices, metrics, and departmental initiatives.
• Contribute to business development activities, including proposal development and bid defense support.
• Liaise with internal stakeholders and external vendors, escalating issues as needed to ensure on‑time delivery.
• Ensure compliance with SOPs, ICH GCP, and applicable regulatory requirements.

What you will bring to the role

• Strong leadership and organizational management skills in planning, strategizing, managing, monitoring, scheduling, and critiquing
• Ability to provide experience and input into initiatives relating to interacting with sites and/or customers
• Strong interpersonal, oral and written communication skills in a fast‑paced, deadline‑oriented, and changing environment
• Demonstrated ability to collaborate across the business
• Team‑oriented work style: seeks and gives guidance
• Understanding of regulatory processes and guidelines
• Understanding of initiation, planning, and execution of clinical projects and overall project planning
• Awareness of ICH GCP Guidelines and the FDA/EU Clinical Trials Directives/National regulations (CTAs, Amendments, Urgent Safety Measures, End of Trial Notifications)
• Proficiency in MS‑Office applications including Microsoft Word, Excel, and PowerPoint; digital systems aptitude

Your experience

• A minimum four‑year degree or nursing degree is required
• Minimum of 4 years CRO experience in Study Start‑Up with country lead or manager experience required
• Proficient in cross‑cultural communication
• Proficient in both spoken and written English

Promotion to the next level is not automatic based on years of experience. Personnel are evaluated on proven competency, level of responsibility, and ability to work independently.

At Worldwide Clinical Trials, we are committed to fostering an inclusive and equitable workplace by providing transparent compensation. The salary range for this position is annually (For hourly paid positions, the stated salary range reflects hourly rates):

United States of America - $86,000.00 - $170,000.00

The salary range provided is intended to give candidates an understanding of potential earnings. Compensation will fall within the provided range, and it not a guarantee of exact salary. The final salary will be determined based on relevant experience, performance, education, and internal equity. In addition to base salary, we offer a competitive benefits package depending on location. We ensure pay equity and transparency and comply with all applicable labor laws. Salary information will be discussed during the interview process, and we encourage candidates to inquire about compensation at any stage.

We love knowing that someone is going to have a better life because of the work we do.