SI/ML Computational Biologist - Academic Graduate Appointee

Lawrence Livermore National Laboratory; Livermore (CA); On-site; USD 75,000 - 86,000; Full time

Benefits offered by this job

Flexible Benefits Package

Relocation Assistance

Education Reimbursement Program

Flexible schedules

401(k)

Job summary

Lawrence Livermore National Laboratory (LLNL) is seeking an Academic Graduate Appointee to support interdisciplinary research at the intersection of super intelligence, machine learning, and computational biology.

The appointee will analyze multiomic data from animal models and human cohorts, applying deep learning and foundation models under guidance to derive molecular programs related to disease progression and immune responses.

Qualifications

• Proficiency in Python and/or R.
• Strong foundation in ML/statistical modeling.
• Experience analyzing high-dimensional biological data.

Responsibilities

• Process and analyze bulk, single-cell, and spatial data using established methods.
• Assist with implementing ML methods, including interpretable models.
• Document code and analyses for reproducibility.
• Present results to internal teams and collaborators.

Skills

Python

R

Linux/Unix

Communication

Q-level clearance

Education

Bachelor's or Master's in CS/Data Science/Bioinformatics

Tools

Git

Nextflow

Snakemake

Job description

Company Description

Join us and make YOUR mark on the World!

Lawrence Livermore National Laboratory (LLNL) has turned bold ideas into world-changing impact advancing science and technology to strengthen U.S. security and promote global stability.

Our mission spans four critical national security areas nuclear deterrence, threat preparedness, energy security, and multi-domain defense empowering teams to take on the toughest challenges of today and tomorrow. With a culture built on innovation and operational excellence, LLNL is a place where your expertise can make a real impact.

Job Description

Note: This is a one-year Academic Graduate Appointee with the possibility of extension to a maximum of two years.

We have an opening for an Academic Graduate Appointee to support interdisciplinary research at the intersection of super intelligence, machine learning, and computational biology. The appointee will assist with processing, integrating, and analyzing large-scale multiomic datasets, including bulk, single-cell, and spatial transcriptomic data from animal models and human cohorts. Using established bioinformatics methods and, under guidance, machine-learning approaches such as deep learning, self-supervised learning, and biological foundation models, the appointee will contribute to analytical and predictive workflows to identify molecular programs associated with disease progression, immune responses, and biological resilience, and support the generation of biological insights. The position offers opportunities to develop technical skills and professional experience under the guidance of experienced staff. This position is in the Integrative Multi-Omics Group of the Biosciences and Biotechnology Division.

This position requires full-time on-site presence due to the nature of the work.

You will

• Collaborate with experimental scientists, computational biologists, computer scientists, and engineers on defined computational and data-analysis assignments under guidance from senior staff.
• Process and analyze bulk transcriptomic, single-cell and spatial transcriptomic data from animal models and human cohorts using established bioinformatics methods, and assist with workflows for multimodal data integration.
• Assist with implementing, testing, and applying established machine-learning methods, including interpretable models, for prediction and representation learning from high-dimensional biological data, under guidance, linking molecular states to disease trajectories and host-response phenotypes.
• Support the training, adaptation, and evaluation of self-supervised and foundation models for biological applications.
• Document code and analyses to support reproducibility.
• Contribute to technical reports, presentations, and potentially peer-reviewed publications.
• Present research progress and technical results to internal teams, collaborators, and other scientific audiences with guidance from senior staff.
• Meet project deadlines and maintain high-quality deliverables.
• Perform other duties as assigned.

Qualifications

• Ability to secure and maintain a U.S. Department of Energy Q-level security clearance, which requires U.S. citizenship and a federal background investigation.
• Bachelor's or Master's degree in computer science, data science, bioinformatics, computational biology, statistics, or a related field.
• Coursework, research, internship, or project experience analyzing high-dimensional biological data (e.g., genomics, transcriptomics) using standard bioinformatics pipelines and statistical methods.
• Foundation in machine learning and statistical modeling demonstrated through coursework, research, or technical projects.
• Proficiency in Python and/or R.
• Proficiency in Linux/Unix, including command-line tools and shell scripting.
• Strong written and verbal communication skills and the ability to work effectively in a collaborative research environment.

Qualifications We Desire

• Exposure to or experience applying machine learning or deep learning methods to biological data, including single-cell, spatial, or multimodal omics, and running large-scale workflows on GPU or high-performance computing (HPC) systems.
• Familiarity with multiomic data integration, transfer learning, or foundation models for biological data.
• Experience with version control (Git) and workflow managers (e.g., Nextflow or Snakemake).
• Interest in immunology, host-pathogen biology, or disease modeling.
• Relevant research experience, publications, internships, or substantial technical projects.

Pay Range

$6,748 - $7,718 Monthly

Please note that the pay range information is a general guideline only. Many factors are taken into consideration when setting starting pay including education, experience, the external labor market, and internal equity.

Additional Information

#LI-Onsite

Position Information

This is a one-year Academic Graduate Appointee, open to those who have been awarded a degree at the time of the employment offer.

Why Lawrence Livermore National Laboratory?

• Included in 2026Best Places to Work by Glassdoor!
• FlexibleBenefits Package
• 401(k)
• Relocation Assistance
• Education Reimbursement Program
• Flexible schedules (*depending on project needs)
• Our values - visithttps://www.llnl.gov/inclusion/our-values

Security Clearance

This position requires a Department of Energy (DOE) Q-level clearance.If you are selected, wewill initiate a Federal background investigation to determine if youmeet eligibility requirements for access to classified information or matter. Also, all L or Q cleared employees are subject to random drug testing. Q-level clearance requires U.S. citizenship.

Pre-Employment Drug Test

External applicant(s) selected for this position must pass a post-offer, pre-employment drug test. This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor.

Wireless and Medical Devices

Per the Department of Energy (DOE), Lawrence Livermore National Laboratory must meet certain restrictions with the useand/or possession ofmobile devices in Limited Areas. Depending on your job duties, you may be required to work in a Limited Area whereyou are not permitted to have a personal and/or laboratory mobile devicein your possession. This includes, but not limited to cell phones, tablets, fitness devices, wireless headphones, and other Bluetooth/wireless enabled devices.

Ifyou useamedical device, whichpairs with a mobile device,you must still follow the rules concerningthe mobile device in individual sections within Limited Areas. Sensitive Compartmented Information Facilities requireseparate approval. Hearing aids without wireless capabilities or wireless that has been disabled are allowed in Limited Areas, Secure Space and Transit/Buffer Space within buildings.

Equal Employment Opportunity

We are an equal opportunity employer that is committed to providing all with a work environment free of discrimination and harassment. All qualified applicants will receive consideration for employment without regard to race, color, religion, marital status, national origin, ancestry, sex, sexual orientation, gender identity, disability, medical condition, pregnancy, protected veteran status, age, citizenship, or any other characteristic protected by applicable laws.

Reasonable Accommodation

Our goal is to create an accessible and inclusive experience for all candidates applying and interviewing at the Laboratory. If you need a reasonable accommodation during the application or the recruiting process, please use our online form to submit a request.

CaliforniaPrivacy Notice

The California Consumer Privacy Act (CCPA) grants privacy rights to all California residents. The law also entitlesjob applicants, employees, and non-employee workers to be notified of what personal information LLNL collects and for what purpose. The Employee Privacy Notice can be accessed here.