Senior Staff Engineer, Modeling and Data Applications

Takeda Pharmaceutical Co.; Lexington (MA); On-site; USD 137,000 - 215,000; Full time

Job summary

Takeda Pharmaceutical Co. in Lexington, MA is seeking a Senior Staff Engineer, Biologics Process Development to develop and optimize modeling tools for biopharmaceutical production.

You will model upstream and downstream processes, evaluate economics, and apply AI/ML approaches to improve manufacturing decisions. The role requires hands-on experience with process modeling apps and programming (Python, Matlab), strong communication, and ability to work across global teams in a fast-paced

Qualifications

• Hands-on experience with process modeling applications (gProms, GoSilico, BioSolve, SIMCA).
• Familiarity with cGMPs and regulatory submissions; ability to work independently and in a team.
• Strong communication and documentation skills; ability to present to non-technical stakeholders.
• Experience with AI/ML model applications and modeling transfer learning.

Responsibilities

• Mechanistic modeling of upstream and downstream processes with simulation software to enhance model-based development.
• Modeling process sustainability and economics for manufacturing platforms.
• Multivariate process trending analysis to optimize manufacturing processes for biopharmaceuticals.
• Apply modeling approaches to process development including model transfer learning.
• Provide modeling support for biopharmaceutical process characterization activities for validation.

Skills

Process modeling

Python

Matlab

Communication skills

Team collaboration

Data analysis

Education

Ph.D. in biochemical engineering/biotechnology/data sciences/predictive modeling

M.S. in biochemical engineering/biotechnology/data sciences

Related quantitative degree

Tools

gProms

GoSilico

BioSolve

SIMCA

MATLAB

Python

Job description

Job Description

Senior Staff Engineer, Modeling

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Senior Staff Engineer, Biologics Process Development in our Lexington office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Senior Staff Engineer working on the Biologics Process Development team, you will be empowered to develop and optimize tools to enable development processes and model process economics for use in manufacturing facilities.

POSITION OBJECTIVES:

The successful candidate will be part of the Data & Modeling Applications Group within Biotherapeutics Process Development and will support process development and optimization of production processes for biopharmaceuticals through modeling approaches.

POSITION ACCOUNTABILITIES:

• Mechanistic modeling of upstream and downstream processes with simulation software applications to enhance model-based process development
• Modeling of process sustainability and economics of new or improved biopharmaceutical manufacturing platforms and fit into manufacturing facilities
• Perform multivariate process trending analysis in support of development and optimization of manufacturing processes for biopharmaceuticals and bioconjugates
• Model impact of innovative strategies on existing and new manufacturing processes
• Apply modeling approaches to process development including model transfer learning
• Provide modeling support for biopharmaceutical process characterization activities in preparation for process validation
• Evaluation of process and cost modeling software applications for use in biopharmaceutical development
• Collaboration with internal and external groups
• Represent the Process Development Department on various project teams
• Development of AI/ML model applications for hybrid models, and the exploration of innovative approaches to model building, including AI/ML techniques.

EDUCATION, EXPERIENCE AND SKILLS:

To Be Considered at the Senior Staff Engineer Level:

• The preferred candidate holds a Ph.D. degree or a M.S. degree in biochemical engineering/biotechnology, data sciences, predictive modeling or closely related fields with 3+ years (PhD.) or 10+ years (M.S.) of experience in modeling and bioprocess development.

Requirements:

• The open position requires hands-on experience in process modeling applications (such as gProms, GoSilico, BioSolve, SIMCA, etc.).
• Additional hands-on and lab-based process and/or high-throughput development experience is preferred.
• The candidate should be familiar with cGMPs for biopharmaceuticals and regulatory submissions and show the ability to work well independently as well as a member of a team.
• High communication skills, excellent written and verbal communication
• Programming skills (e.g. Matlab, Python)
• Ability to present findings clearly to non-technical stakeholders
• Ability to work in fast-paced environments
• Teamwork skills for working in a diverse, global environment
• Willingness to stay updated with the latest industry trends and technologies

TRAVEL REQUIREMENTS:

• May require approximately 10-20% travel

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Lexington, MA

U.S. Base Salary Range:

$137,000.00 - $215,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

For information about our benefits, please click here.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Lexington, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

YesIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.