Senior / Staff Cloud Platform Engineer (ML)

Calico Life Sciences; South San Francisco (CA); On-site; USD 220,000 - 290,000; Full time

Job summary

Calico Life Sciences seeks a Senior / Staff Cloud Engineer to lead the execution and operation of our next-generation ML platform on Google Cloud. You will design infrastructure-as-code, secure perimeters, automate identity management, and migrate workflows into a unified, compliant infrastructure so researchers can train and deploy ML models.

This role emphasizes DevSecOps, platform modernization, and enabling scientists while ensuring stringent security.

Qualifications

• BS/MS with 7+ years or PhD with 4+ years of relevant software engineering, DevSecOps, or Cloud architecture experience.
• Strong programming skills in Python.
• Strong hands-on experience with Google Cloud Platform (GCP) core services.
• Experience with Kubernetes cluster administration.
• Experience with Terraform, building CI/CD pipelines, and containerization (Docker).
• Must be willing to work onsite at least four days a week.

Responsibilities

• Foundational Impact: Deliver our next-generation ML platform.
• Lead the consolidation and modernization of our compute environments, and accelerate the whole company's R&D cycle.
• GCP Foundation: Lead the centralization of GCP projects into a unified, compliant landing zone.
• Design secure perimeters to protect sensitive biological data, and build automated guardrails using Terraform.
• GKE Cluster Administration: Design, deploy, and maintain robust GKE clusters tailored for distributed ML training and batch processing workloads.
• Troubleshoot node-level GPU/TPU issues, manage scheduling add-ons, and optimize cluster autoscaling.
• Developer Experience & Onboarding: Design intuitive onboarding processes and "paved paths" for scientists to seamlessly onboard onto the new platform.
• FinOps: Manage org-level GPU/TPU compute capacity, implement centralized billing and cost reporting, and build comprehensive monitoring dashboards to track cluster utilization and optimize R&D expenditure.

Skills

Python

Education

BS/MS with 7+ years or PhD with 4+ years in relevant software engineering, DevSecOps, or Cloud architecture

Tools

GCP core services

Kubernetes

Terraform

Docker

CI/CD pipelines

Job description

Who We Are

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Who We Are

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description

Calico seeks a Senior / Staff Cloud Engineer to lead the execution and operation of our next-generation machine learning (ML) platform. As the technical authority for our Google Cloud Platform (GCP) environment, you will build infrastructure-as-Code (IaC), design secure perimeters, automate identity management, and migrate existing workflows into a unified, compliant infrastructure.

If you are passionate about DevSecOps, IaC, and building "paved paths" that empower scientists while enforcing rigorous security, this is the role for you. You will be the critical bridge that allows our ML Systems and Research engineers to train and deploy ML models for frontier BioML research.

Please note: No biology or life sciences background is required for this role.

Position Responsibilities

• Foundational Impact:
  • Deliver our next-generation ML platform
  • Lead the consolidation and modernization of our compute environments, and accelerate the whole company's R&D cycle
• GCP Foundation:
  • Lead the centralization of GCP projects into a unified, compliant landing zone
  • Design secure perimeters to protect sensitive biological data, and build automated guardrails using Terraform
• GKE Cluster Administration:
  • Design, deploy, and maintain robust GKE clusters tailored for distributed ML training and batch processing workloads
  • Troubleshoot node-level GPU/TPU issues, manage scheduling add-ons, and optimize cluster autoscaling
• Developer Experience & Onboarding:
  • Design intuitive onboarding processes and "paved paths" for scientists to seamlessly onboard onto the new platform
• FinOps:
  • Manage org-level GPU/TPU compute capacity, implement centralized billing and cost reporting, and build comprehensive monitoring dashboards to track cluster utilization and optimize R&D expenditure

Position Requirements

• BS/MS with 7+ years or PhD with 4+ years of relevant software engineering, DevSecOps, or Cloud architecture experience
• Strong programming skills in Python
• Strong hands-on experience with Google Cloud Platform (GCP) core services
• Experience with Kubernetes cluster administration
• Experience with Terraform, building CI/CD pipelines, and containerization (Docker)
• Must be willing to work onsite at least four days a week

Nice To Have

• A strong intellectual curiosity for life sciences
• Experience managing Kubernetes for HPC or ML workloads
• Experience supporting Machine Learning orchestration and queueing frameworks (e.g., Kueue, Ray)
• Experience reading and debugging ML Python code
• Experience implementing compliant cloud architectures (e.g., SOC2, HIPAA, or similar frameworks)
• Familiarity with Golang
• Strong communication skills with a proven ability to guide users through migration

The estimated base salary range for this role is $220,000 - $290,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.