Senior Scientist, Translational PK/PD

Merck & Co.

West Point (PA)

Hybrid

USD 129,000 - 203,000

Full time

13 days ago

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Benefits offered by this job

Hybrid work

Medical, dental, vision

401(k) retirement plan

Job summary

Merck & Co. in the US is seeking a Senior Scientist for Translational PK/PD in our Translational PK/PD organization.

You will design and execute PK/PD analyses, guiding drug discovery with a focus on biologics and peptides, under supervision. Responsibilities include integrating in vitro/in vivo data to build PKPD, PBPK, and QSP models, collaborating across PDMB and Discovery teams, and helping create automated modeling workflows.

Qualifications

Master's (with 3+ years), PharmD (with 1 year) or Ph.D. in relevant fields and experience in drug discovery / development.
Hands‑on translational PK/PD modeling with standard software (Matlab, OSP Suite, Monolix, R).

Responsibilities

Serve as PK/PD modeler in cross-functional teams to inform decisions on discovery and dose prediction.
Integrate in vitro and in vivo data to build PKPD, PBPK, QSP or other mechanistic models.
Collaborate to design studies and modeling plans to identify and optimize drug candidates.
Contribute to automated workflows for modeling platforms to inform human PK/PD and dose projections.
Develop leadership skills in translational modeling and drug discovery.

Skills

Biostatistics

Data Analysis

Data Modeling

Data Science

Drug Discovery Process

Interdisciplinary Collaboration

MATLAB

Pharmacodynamics

Pharmacokinetics

PKPD Modeling

Statistical Analysis

Translational Pharmacokinetics and Phy

Education

Master's degree with 3+ years / PharmD with 1 year / Ph.D.

Tools

MATLAB

OSP Suite

Monolix

Job description

Job Description

The department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) is seeking a curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK/PD Senior Scientist is a skilled mathematical modeler and scientist who designs and executes analyses, with supervision, guiding drug discovery strategy with a focus on biologics, protein therapeutics, and peptides.

Responsibilities

The Translational PK/PD Senior Scientist will:

Serve as PK/PD modeler in cross-functional teams, to make model-informed decisions about drug discovery, modality selection, and dose prediction across therapeutic areas;
Integrate in vitro and in vivo data to build PKPD, PBPK, quantitative systems pharmacology (QSP), or other mechanistic modeling platforms of drug disposition and pharmacology, to support forward/reverse translation for both established and novel therapeutic targets;
Collaborate across our PDMB and broader Discovery / Translational organization to design experimental studies and modeling plans, to identify and optimize drug candidates;
Collaborate in the design of automated workflows for implementing modeling platforms, to inform human PK/PD and dose projections;
With guidance from experienced modelers, continue to build expertise and leadership skills in translational modeling and drug discovery.

In addition to the responsibilities described above, the Senior Scientist will demonstrate strong leadership and communication skills, drawing upon their training and experience to enable model-informed drug discovery.

NOTE: This role is available in South San Francisco, CA, West Point, PA or Boston, MA based on candidate preference.

QUALIFICATIONS

Education

Master's (with 3+ years), PharmD (with 1 year) or Ph.D. in pharmacokinetics/pharmacodynamics, mathematics, applied mathematics, systems biology, computational biology, chemical/biomedical engineering, statistics/biostatistics or related discipline and experience with increasing responsibility and independence in drug discovery / development, within industry, academia, regulatory or non-profit settings

Required Experience and Skills

Experience performing hands‑on translational PKPD modeling using standard modeling software (e.g., Matlab, OSP Suite, Monolix, R)
Strong skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and/or statistics

Preferred Experience and Skills

Experience using mathematical modeling to inform decisions related to discovery / development of biologics, protein therapeutics, and/or peptides
Demonstrated ability to work in interdisciplinary teams and in collaborative problem solving
Expertise in developing novel PKPD, PBPK, QSP, or related mechanistic modeling approaches

Required Skills

Biostatistics
Data Analysis
Data Modeling
Data Science
Drug Discovery Process
Interdisciplinary Collaboration
MATLAB
Pharmacodynamics
Pharmacokinetics
PKPD Modeling
Statistical Analysis
Translational Pharmacokinetics and Pharmacodynamics (PKPD)

US and Puerto Rico Residents Only

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.

Equal Employment Opportunity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.

We comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

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Salary

$129,000.00 - $203,100.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

Benefits

We offer a comprehensive package of benefits.

Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits .

San Francisco Residents Only

We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only

We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status

Regular

Relocation

Domestic/International

VISA Sponsorship

Yes

Travel Requirements

10%

Flexible Work Arrangements

Hybrid

Shift

1st - Day