Senior Scientist, Toxicology

Merck; West Point (PA); Vor Ort; USD 106.000 - 167.000; Vollzeit

Zusammenfassung

Merck in the United States (Pennsylvania – West Point) seeks a toxicologist to lead and monitor toxicity studies (GLP and non-GLP) across modalities. You will integrate data from clinical pathology, pathology, and toxicokinetics to create safety profiles for drug candidates, with potential growth toward broader nonclinical safety leadership.

The role involves leading studies, ensuring regulatory rigor, and collaborating across teams to deliver high-quality results within timelines.

Qualifikationen

• PhD in toxicology or related field is required.
• Strong leadership and collaboration with cross-functional teams.
• Experience in design/conduct of in vivo toxicity studies and regulatory reporting.

Aufgaben

• Serve as Study Director/Study Monitor for acute through chronic general toxicology studies.
• Interpret and integrate data from various sources for regulatory submissions.
• Lead or participate in method development and cross-functional projects.

Kenntnisse

Animal Handling

CROs

Data Evaluation

Detail-Oriented

Experimentation

Exploratory Research

Good Laboratory Practices (GLPs)

In Vivo Models

Laboratory Research

Pre-Clinical Developments

Report Preparation

Situational Leadership

Study Directing

Study Monitoring

Timeline Management

Toxicological Risk Assessment

Toxicology

Ausbildung

PhD in toxicology, pharmacology, pharmaceutical sciences, or related scientific discipline

Tools

GLP Study Director experience

Jobbeschreibung

Job Description

The Nonclinical Drug Safety department is seeking a motivated and talented toxicologist to conduct and/or monitor toxicity studies (GLP and non-GLP) as a Study Director or Study Monitor. Toxicologists at our Company are integral members and leaders of collaborative cross functional scientific teams, addressing challenges from early discovery to late development. Our toxicologists provide scientific leadership in the design and overall conduct of in vivo studies and integrate the findings from all contributing scientists into reports that characterize the safety profile of drug candidates. The individual also will possess the attributes and interest to expand their career toward a broader strategic Nonclinical Drug Safety role. This could include development toward future opportunities as the nonclinical safety lead on discovery or clinical development programs.

Key Responsibilities

• Serve as the single point of control (Study Director) on assigned acute through chronic general toxicology studies across all modalities. Interact with technical, veterinary, and scientific staff to ensure that the study is in compliance with the protocol, amendments, Standard Operating Procedures, regulations, safety guidelines, and company policies and procedures.
• Critically analyze and interpret data. Integrate data from other areas (e.g., clinical pathology, pathology, toxicokinetics) in written reports used for regulatory submissions, and communicate results within established timelines.
• Ensure regulatory rigor, proactive risk identification, and timely study execution.
• Build strong collaborative relationships and influences without authority, contributing to an inclusive team environment.
• Deliver high-quality results with accountability and agility, translating objectives into action while continuously improving, embracing change, and demonstrating leadership.
• As needed, lead and/or participate in method development, inter-group initiatives, and various related scientific projects.

Education

• PhD in toxicology, pharmacology, pharmaceutical sciences, or related scientific discipline.

Requirements

• Strong interest in collaborating with cross-functional teams and communicating openly and often with colleagues.
• Strong listening and leadership skills
• Ability to communicate clearly using verbal and written formats, including presentations

Preferred

• GLP Study Director experience
• Familiarity with outsourced study monitoring
• Demonstrated understanding of Good Laboratory Practices (US FDA 21 CFR Part 58)
• Familiarity with ICH safety guidelines

Required Skills

Animal Handling, Contract Research Organizations (CROs), Data Evaluation, Detail-Oriented, Experimentation, Exploratory Research, Good Laboratory Practices (GLPs), In Vivo Models, Laboratory Research, Pre-Clinical Developments, Report Preparation, Situational Leadership, Study Directing, Study Monitoring, Timeline Management, Toxicological Risk Assessment, Toxicology

US And Puerto Rico Residents Only

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As An Equal Employment Opportunity Employer, We Provide Equal Opportunities To All Employees And Applicants For Employment And Prohibit Discrimination On The Basis Of Race, Color, Age, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Protected Veteran Status, Disability Status, Or Other Applicable Legally Protected Characteristics. As a Federal Contractor, We Comply With All Affrhoative Action Requirements For Protected Veterans And Individuals With Disabilities. For More Information About Personal Rights Under The U.S. Equal Opportunity Employment Laws, Visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

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The primary location for this posting is:

USA - Pennsylvania - West Point

Where required by law, the compensation range for this role is provided below.

The salary range for the primary location of this role is:

$106,200.00 - $167,200.00

This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

Additional location(s)

Please note the salary range above applies to the Primary Location of the position. Where a role has other listed locations, different compensation guidelines may apply. You may find the salary ranges for additional locations below. If the salary range is not listed for the location you are applying to, our Talent Acquisition team will provide further information to you relevant to your location.

San Francisco Residents Only

We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.

Los Angeles Residents Only

We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status

Regular

Relocation

Domestic

VISA Sponsorship

No

Travel Requirements

10%

Flexible Work Arrangements

Not Applicable

Shift

Not Indicated

Valid Driving License

No

Hazardous Material(s)

OEB4, bloodborne pathogens, beta lactam, standard lab reagents

Job Posting End Date

10/27/2026

• A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID

R421384