Senior Scientist, siRNA Synthesis

ABBVIE; Worcester (MA); On-site; USD 110,000 - 209,000; Full time

Benefits offered by this job

Medical/dental/vision insurance

401(k) program

Paid time off

Job summary

AbbVie is seeking a Principal Research Scientist I to lead the siRNA synthesis platform, establishing capabilities for synthesis, purification, and analysis. You will generate high-quality siRNA materials to advance genetic medicine studies, working with cross-functional teams in a dynamic pharmacology environment.

The role demands strong expertise in oligonucleotide and RNA chemistry, problem solving, and effective communication to drive projects and mentor junior scientists.

Qualifications

• Degree in Chemistry, Chemical Biology, Biochemistry, or related field with 0–4+ years (PhD), 8–10+ years (MS), or 10–12+ years (BS) biotech/pharma experience.
• Proven gram-scale oligonucleotide synthesis and purification method development.
• Strong knowledge of oligonucleotide and RNA chemistry.
• Experience collaborating with analytical and conjugation teams.
• Ability to solve complex technical problems and drive projects.

Responsibilities

• Lead siRNA synthesis platform for multiple study stages.
• Perform solid-phase oligonucleotide synthesis, deprotection, purification, and desalting.
• Troubleshoot synthesis/purification to improve yield and purity.
• Support characterization, data interpretation, and quality assessment with analytical teams.
• Collaborate with conjugation team to advance siRNA conjugates.
• Ensure rigorous documentation and compliance with quality standards.
• Mentor junior scientists and contribute to a high-performing team.

Skills

Oligonucleotide synthesis

Purification methods

RNA chemistry

Cross-functional collaboration

Problem solving

Documentation & data integrity

Education

PhD/MS/BS in Chemistry or related field

Tools

Oligonucleotide synthesizers

Liquid chromatography systems

Job description

• Compensation: USD 109500 - USD 208500 - yearly

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com . Follow @abbvie onLinkedIn, Facebook ,Instagram ,X andYouTube.

Job Description

The Biotherapeutic and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist I to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. This individual will serve as a subject matter expert in oligonucleotide synthesis and purification, with responsibility for generating high-quality siRNA materials for advancing genetic medicine studies.

Responsibilities:

• Lead the siRNA synthesis platform to support various stages of siRNA studies.
• Perform solid-phase oligonucleotide synthesis, deprotection, purification, and desalting of siRNA.
• Troubleshoot synthesis and purification challenges to improve yield, purity, and scalability.
• Work closely with the siRNA analytical colleagues to support characterization, data interpretation, and quality assessment of siRNA materials.
• Collaborate closely with the conjugation team to advance siRNA conjugate development and support platform and project objectives.
• Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
• Track emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
• Mentor junior scientists and contribute to a collaborative, high-performing team environment.

Qualifications

• BS, MS, or PhD in Chemistry, Chemical Biology, Biochemistry, or a related field with typically 0-4+ years (PhD), 8-10+ years (MS), or 10-12+ years (BS) of relevant biotech or pharmaceutical industry experience.
• Proven track record in gram-scale oligonucleotide synthesis using oligonucleotide synthesizers, as well as development of oligonucleotide purification methods using liquid chromatography systems.
• Strong knowledge of oligonucleotide chemistry and RNA chemistry.
• Experience working cross-functionally with analytical and conjugation teams.
• Demonstrated ability to independently solve complex technical problems and drive projects forward.
• Excellent communication, collaboration, and organizational skills.
• Strong track record of presenting scientific data to internal and external stakeholders.

Position will be filled at level commensurate with extent of education, experience, and accomplishment - Senior Scientist I or Senior Scientist II

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.
• This job is may be eligible toparticipatein our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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