Senior Scientist, siRNA Screening Automation and Molecular Analytics

BioSpace; Worcester (MA); On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Paid time off

Medical/Dental/Vision insurance

401(k)

Job summary

AbbVie is seeking a Senior Scientist in its Biotherapeutic and Genetic Medicine division to support automated high-throughput siRNA screening workflows and data analysis. The role focuses on building scalable, automation-enabled workflows to accelerate lead discovery across therapeutic areas.

The candidate will lead RNA extraction and RT-qPCR workflows, contribute to NGS-based expression profiling, and collaborate with program teams and bioinformatics to interpret large datasets.

Qualifications

• PhD/MD/BS/MS with extensive biotech/pharma industry exposure depending on degree level.
• Hands-on experience with automation and high-throughput workflows.
• Experience with RNA extraction and RT-qPCR development.
• NGS library prep and data interpretation in automation-enabled pipelines.
• Experience with siRNA screening or RNA biology is preferred.
• Collaborative work with cross-functional teams and bioinformatics.
• Ability to document, standardize, and troubleshoot screening workflows.

Responsibilities

• Lead high-throughput siRNA screening workflows using automated systems.
• Develop and optimize RNA extraction, RT-qPCR, and RNA-seq workflows.
• Design experiments to assess siRNA activity, potency, and selectivity.
• Maintain data analysis workflows for screening datasets and QC.
• Advance NGS-based strategies for gene expression profiling with automation.
• Mentor junior scientists and collaborate with platform teams.

Skills

Laboratory automation

High-throughput screening

RNA extraction

RT-qPCR

RNA-seq library preparation

NGS data analysis

Biotech/Pharma experience

Bioinformatics collaboration

Cross-functional collaboration

Education

PhD in Molecular Biology/Genomics/Bioinformatics

Tools

LIMS

Automation scripting

Python

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Job Description

AbbVies Biotherapeutic and Genetic Medicine (BGM) department is seeking a highly motivated Senior Scientist to support the development and operation of a high-throughput siRNA screening platform. This role will focus on automation-enabled screening workflowsanddata analysis. The successful candidate will work closely with platform and program teams to build robust, scalable workflows that accelerate siRNA lead discovery and optimization across multiple therapeutic areas.

Responsibilities

• Lead execution of high-throughput siRNA screening workflows usingautomatedliquid-handling and other laboratory automation systems.
• Develop, optimize, and troubleshoot automated methods for sample preparation workflows, including RNA extraction, RT-qPCR, and RNA-seq library preparation.
• Design and execute experiments to evaluate siRNA activity, potency, and selectivity using molecular biology assay platforms.
• Establish and maintain data analysis workflows for screening datasets, including assay QC, normalization, hit assessment, and interpretation of experimental results.
• Drive development and implementationofnext-generation sequencing (NGS)-based strategiesusing automationfor gene expression profiling.
• Partner withdifferent groups,cross-functional scientistsandbioinformatics,to support analysis and interpretation of large screening and sequencing datasets.
• Contributeto the improvement, standardization, and documentation of screening workflows, assay protocols, and automation procedures.
• Identify technical issues proactively and implement solutions to improve assay robustness, throughput, and reproducibility.
• Present results clearly to project teams and platform leadership, and contribute to scientific discussions, experimental planning, and strategy.
• Mentor junior scientists or research associates as needed and contribute to a collaborative, high-performing laboratory environment.

Qualifications

• BS, MS, or PhD in Molecular Biology,Genomics,Bioinformatics, Bioengineering, or a related discipline with typically 0-4+ years (PhD), 8-10+ years (MS), or 10-12+ years (BS) of relevant biotech or pharmaceutical industry experience.
• Strong hands‑on experience with laboratory automation,high-throughputscreening workflows,andcoding for automationsystems.
• Deep experience with RNA extractionandRT-qPCR assay development, execution, and troubleshooting.
• Familiarity with NGS workflows for library construction and gene expression profiling, including integration of automation with NGS library preparation or other downstream molecular workflows.
• Experience with siRNA screening, oligonucleotide therapeutics, or RNA biology strongly preferred.
• Familiarity with scripting, data processing tools, or bioinformatics collaboration models.
• Prior experience supporting platform buildout in a matrixed drug discovery environment.
• Strong organizational skills and attention to detail, with ability to manage multiple priorities in a fast‑paced environment.
• Excellent communication skills and demonstrated ability to work effectively in cross‑functional teams.

Position will be filled at level commensurate with extent of education, experience, and accomplishment - Senior Scientist I or Senior Scientist II

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemay ultimately pay more or less than the posted range. This range may bemodified in thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipate in our short-term incentiveprograms.
• This job may be eligible to participate in our long-term incentive plan.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company'ssoleandabsolutediscretion unless and until paid andmay bemodified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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