Senior Scientist, Safety Assessment & Toxicology Data Analytics

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company; United States; Remote; USD 85,000 - 130,000; Full time

Benefits offered by this job

401(k) plan

Medical insurance

Dental insurance

Vision insurance

Life insurance

Generous paid time off

Wellness program

Job summary

Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company, is seeking a Senior Scientist to lead Safety Assessment with a focus on data auditing, regulatory SENDs, and cross-functional collaboration. This 100% remote role operates within the US, supporting early pipeline decision-making and governance processes.

The position emphasizes advanced data visualization, regulatory auditing, literature synthesis, and PDT leadership, requiring strong toxicology operations experience

Qualifications

• Advanced data visualization and analytics for toxicology datasets.
• Auditing and regulatory review of SEND data structures.
• Literature investigations to inform safety strategies.
• Leadership in PDT governance and cross-functional collaboration.

Responsibilities

• Lead data models and visualization for multi-dose toxicology data and safety endpoints.
• Oversee SEND data reviews, QC, and alignment with study reports for regulatory filings.
• Synthesize literature to identify target-mediated safety risks and inform strategies.
• Co-author data packages and briefing materials for governance panels.
• Serve as scientific liaison across Safety Assessment, DMPK, CMC, and Project Management.

Skills

Data visualization

Regulatory auditing

Literature review

Cross-functional leadership

Stakeholder communication

Toxicology data handling

Education

MS in Toxicology or related field

BS in related life sciences

Tools

GraphPad Prism

Spotfire

Excel macros

Python

R

Job description

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa’s OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions.

__Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work in 2026.

Description of Role

We are seeking an analytically elite, strategically minded Senior Scientist to join our Safety Assessment team. This is a 100% non-laboratory position designed for a seasoned bioscientist or toxicology operations expert who thrives at the intersection of dataset auditing, mechanistic evaluation, and cross-functional project leadership.

As a Senior Scientist, you will serve as a vital scientific and strategic hub connecting Centessa’s internal toxicology leaders with Project Development Teams (PDTs) and adjacent disciplines (including DMPK, CMC, Regulatory, and Clinical Operations). You will own the analytical pipeline for incoming toxicology studies—spearheading the audit of regulatory SEND datasets, engineering data visualizations of complex toxicology endpoints, and authoring authoritative literature reviews. Your insights will directly shape investigative toxicology strategies, driving early pipeline decision‑making and securing project endorsements at internal governance committees.

Key Responsibilities

• Advanced Data Visualization & Analytics: Lead the architectural design and execution of data models that transform raw, multi-dose toxicology data streams, clinical pathology tables, and safety pharmacology metrics into publication-ready visual tools (e.g., exposure‑margin heatmaps, benchmark dose plots, and cumulative trend diagnostics) to clearly define therapeutic windows.
• SEND Strategy & Regulatory Auditing: Oversee the review and quality control of incoming Standard for the Exchange of Nonclinical Data (SEND) datasets from CRO vendors. Ensure absolute compliance, schema validation, and exact data alignment with finalized nonclinical study reports prior to regulatory filing and archival.
• Mechanistic Synthesis & Literature Architecture: Conduct rigorous, comprehensive scientific literature investigations to proactively assess target‑mediated or chemotype‑specific safety risks. Synthesize complex, ambiguous biological data into clear, actionable technical memos that inform investigative toxicity strategies.
• PDT & Governance Leadership: Partner closely with Toxicology Leads to co‑author high‑impact data packages, briefing books, and executive slide decks. Actively participate in defending safety strategies and securing program endorsements within Project Development Teams (PDTs) and formal internal governance panels.
• Cross‑Functional Synergy: Act as a senior scientific liaison between Safety Assessment, CMC (for compound inventory tracking), DMPK (for toxicokinetic integration), and Project Management to ensure nonclinical safety deliverables map smoothly to aggressive global project milestones.

Qualifications

• Education: B.S. or M.S. degree in Toxicology, Pharmacology, Cellular/Molecular Biology, Bioinformatics, or a related life sciences discipline.

• Experience Required:

  • With an M.S. degree: 6–8+ years of highly relevant biotechnology, pharmaceutical, or tier‑one CRO industry experience.
  • With a B.S. degree: 8–10+ years of extensive industrial drug‑development, data management, and toxicology operations experience.

• Core Technical Competencies:

  • Expert‑level understanding of preclinical toxicology datasets, histopathology reporting structures, and study designs.
  • Hands‑on proficiency auditing, validating, or working directly with regulatory SEND data structures.
  • Advanced capability utilizing scientific data software to build complex data structures (e.g., GraphPad Prism, Spotfire, Excel macros, or specialized Python/R data visual tools).

• Leadership & Influence: Superb technical writing skills paired with a demonstrated ability to distill vast pools of complex data into clear arguments capable of convincing diverse, cross‑functional scientific leaders.

Compensation

The annual base salary range for this position is $85,000 to $130,000. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, job knowledge and location.

In addition to base pay, this role is eligible for a discretionary annual bonus. The Company also offers a comprehensive benefits package, which includes a 401(k) plan, company‑sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.

Work Location

This role is remote and based in the US, with occasional travel.

POSITION:

Full-Time, Exempt

EEOC Statement:

Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Please note:

We will not assign referral rights for any unsolicited resumes from recruitment agencies.