Senior Scientist - PKDM-BA

BioSpace; South San Francisco (CA); Sur place; USD 120 000 - 180 000; Plein temps

Avantages offerts par ce poste

Health and welfare plans

Retirement and savings plan

Discretionary annual bonus

Résumé du poste

Amgen in South San Francisco, CA is seeking a Senior Scientist to drive ADME investigations for large molecule therapeutics. The role focuses on designing and executing biological and biophysical experiments to understand in vivo clearance and biodistribution, with an emphasis on assay/technology development for PKDM programs.

You will interpret data, communicate results to project teams, and may contribute to department strategy as PKDM project representative.

Qualifications

• PhD/PharmD/MD with relevant post-doc experience, or equivalent.
• Masters with 3+ years related experience or Bachelors with 5+ years.
• Biologics/ADME preclinical and pharmacokinetics knowledge preferred.

Responsabilités

• Design and execute biological and biophysical experiments to understand ADME properties of large molecule therapeutics.
• Develop assays/techniques to define in vivo clearance and biodistribution mechanisms.
• Interpret data and communicate results to project teams; maintain ELN records.
• Possibly drive department strategy as PKDM project representative.

Connaissances

Biophysical analytics

Protein biochemistry

Cell biology techniques

Data interpretation

Excellent communication

Collaborative work

Formation

PhD/PharmD/MD

Masters with experience

Bachelors with experience

Description du poste

Senior Scientist - PKDM-BA

What you will do

Lets do this. Lets change the world. The responsibilities of the successful candidate will be to design and execute biological and/or biophysical experiments to understand the ADME properties of large molecule therapeutics (and non-traditional small molecule therapies) in support of both drug discovery and early development programs.

This is a lab-based role, with an emphasis on assay/technology development for the purposes of defining mechanisms of in vivo clearance and/or biodistribution processes. This role requires an understanding of preclinical ADME and bioanalytical techniques and an individual that can work collaboratively in a fast-paced work environment.

Other responsibilities include data interpretation and communication of results to project team representatives and electronic laboratory notebook keeping of results. The candidate may also be responsible for developing and executing department strategy for drug candidate teams as a PKDM project representative.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
• Masters degree and 3 years of related experience
• Bachelors degree and 5 years of related experience

Preferred Qualifications

• PhD or MS in immunology, cell biology, biochemistry, biophysics, or equivalent.
• 2+ years of protein therapeutics drug discovery and development experience in biotech industry, basic understanding of protein therapeutics pharmacokinetics.
• Expertise, and a strong interest in evaluating protein-protein interactions using modern biophysical analytic techniques.
• Expertise in protein biochemistry and/or cell biology techniques, including reagent preparation, assay development, optimization and troubleshooting.
• Experience translating biochemical and biophysical observations and phenomena into relevant cellular and animal-based models with mechanistic insights is desirable.
• Excellent communication and interpersonal skills and the ability and interest to learn and deliver results in a fast-paced, demanding environment.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Benefits

• In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include
• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

Equal Opportunity Employer

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.