Senior Scientist, Pharmacokinetics

Merck; West Point (PA); In loco; USD 117.000 - 184.000; Tempo pieno

Descrizione del lavoro

Merck in West Point, PA seeks a Senior Scientist in PDMB to drive LC-MS method design for antibodies, peptides, and drug conjugates, leading automation-enabled discovery workflows and cross-site collaboration.

Bring deep LC-MS expertise for macrocyclic peptides and monoclonal antibodies, plus leadership and teamwork to advance drug candidates through early discovery and development in a fast-paced, research-driven environment.

Competenze

• Demonstrated method development and validation experience with LC/MS for macrocyclic peptides, monoclonal antibodies and drug conjugates.
• Hands-on experience with chromatographic separation and MS methodologies for therapeutic proteins and peptides.
• Strong leadership, communication and collaboration to deliver high-quality results in a fast-paced, team-oriented environment.
• Foster a team-based approach to research and synergistic collaboration across sites.

Mansioni

• Independently design and execute LC-MS methods for antibodies, peptides, and conjugates on HRMS platforms.
• Provide leadership for automation-enabled discovery workflows to increase throughput and data generation.
• Characterize large molecule drug properties using in vitro matrices to support candidate selection.
• Collaborate with PDMB experts in Boston, South San Francisco and West Point to optimize drug candidates.

Conoscenze

ADME

Cell-Based Assays

Drug Metabolism

Electronic Lab Notebook

HRMS

In Vitro Research

Monoclonal Antibodies

Peptides

Pharmacokinetics

Formazione

PhD/MS/BS with relevant experience

Strumenti

N/A

Descrizione del lavoro

Job Description

Our Company is a global health care leader with a diversified portfolio of prescription medicines, vaccines, and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Our Company has codified its legacy for over a century. Our Company's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

At Our Company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthroughs. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility, and scientific acumen of our team. We are creating an organization that is inspired by invention and founded on a culture of respect and collaboration. At Our Company Research Laboratories, you'll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a strategic-thinking and collaborative Senior Scientist to contribute to Our Company's drug discovery and early clinical development efforts. This position will be based at our research laboratories in West Point, PA.

In This Exciting Position, Your Primary Roles Will Include

• Independent design and execution of LC-MS methods to characterize therapeutic antibodies, peptides, and various drug conjugates using LC-MS based platforms including high resolution (HRMS) mass spectrometers.
• Provide scientific leadership for automation-enabled discovery workflows, helping define future capabilities that increase throughput, reproducibility, and data generation across optimization platforms.
• Utilization of state-of-the-art bioanalytical approaches to characterize large molecule drug properties in various in vitro matrices to support candidate selection.
• Close collaboration with PDMB subject‑matter experts in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at building highly efficient strategies to identify and optimize drug candidates.

Education Minimum Requirement

• Ph.D (with 0 – 3 years relevant experience) or Master’s (minimum of 6 years relevant experience) or Bachelor’s (minimum of 10 years relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field

Required Experience And Skills

• Demonstrated method development and validation experience with various platforms with deep expertise in LC/MS for macrocyclic peptides and monoclonal antibodies and drug conjugates.
• Strong hands‑on experience with different chromatographic separation and mass spectrometry methodologies for analysis of therapeutic proteins and peptides.
• Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high‑quality results in a team‑oriented, fast‑paced environment.
• Foster a team‑based approach to research. Commitment to working synergistically and harmoniously with others.

Preferred Experience And Skills

• Experience with DMPK in vitro and in vivo experimental design and analysis.
• Familiarity with electronic laboratory notebooks and related record‑keeping approaches.
• Experience working within a research‑driven pharmaceutical company.
• Strong publication track record.

Required Skills

ADME, Cell‑Based Assays, Drug Metabolism, Electronic Lab Notebook (ELN), High Resolution Mass Spectrometry (HRMS), In Vitro Research, Monoclonal Antibodies, Peptides, Pharmacokinetics

US And Puerto Rico Residents Only

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.

Requirements

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts

Primary location for this posting is:

USA - Pennsylvania - West Point

Salary

The salary range for the primary location of this role is:

$117,000.00 - $184,200.00

This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable.

Benefits

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

Additional location(s):

Please note the salary range above applies to the Primary Location of the position. Where a role has other listed locations, different compensation guidelines may apply. You may find the salary ranges for additional locations below. If the salary range is not listed for the location you are applying to, our Talent Acquisition team will provide further information to you relevant to your location.

Additional location(s) Compensation Information:

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:

We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Employee Status

Regular

Relocation

Domestic

VISA Sponsorship

No

Travel Requirements

10%

Flexible Work Arrangements

Not Applicable

Shift

Not Indicated

Valid Driving License

No

Hazardous Material(s)

NA

Job Posting End Date

• A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID

R423922