Senior Scientist or Principal Scientist, Targeted Proteomics

Kymera Therapeutics; Watertown (MA); On-site; USD 115,000 - 215,000; Full time

Job summary

Kymera Therapeutics is seeking a scientific leader to drive targeted proteomics programs across discovery and preclinical studies. You will design and execute MS-based assays, collaborate with cross-functional teams, and influence program decisions with data.

The role requires a PhD or equivalent industry experience in proteomics, with expertise in PRM/MRM and DIA workflows, plus experience managing CRO partnerships and communicating complex results to leadership.

Qualifications

• PhD or equivalent with industry experience in targeted proteomics.
• Experience translating biology questions into MS workflows.
• Proven track record managing external CRO partnerships.

Responsibilities

• Lead targeted proteomics programs across discovery and preclinical stages.
• Develop and transfer sensitive MS assays (PRM/MRM, DIA) to support PD profiling.
• Collaborate with cross-functional teams to guide program decisions with data.

Skills

Scientific leadership

Cross-functional collaboration

Communication skills

Project management

Analytical mindset

Education

PhD in Biochemistry, Biology, Chemistry, or Chemical Biology

BS/MS with 8+ years relevant experience

Tools

NanoLC

Orbitrap MS

PRM/MRM assays

DDA/DIA data analysis

Skyline

Job description

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients' lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston's top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn.

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.


• COLLABORATE: We value trust transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.


• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you'll make an impact:

• Scientific Leadership and Experimental Strategy:




• Partner with cross-functional project teams to define key scientific questions that can be addressed by targeted proteomics.




• Collaborate with stakeholders to prioritize studies based on urgency and program impact.




• Translate key program questions into targeted proteomics experiments, execute studies analyze and interpret data, and communicate the findings to cross-function teams to enable programdecision-making.




• Targeted Proteomics and Assay Development:




• Drive TPD research programs through development and application of targeted protein mass spectrometry (MS) assays using state-of-the-art LC-MS systems- including nano-LC and Orbitrap platforms.




• Generate pharmacodynamic (PD) profile across a wide variety of biological matrices (e.g. cells, tissues, biofluids) from both human and preclinical species.




• Develop, optimize, qualify and transfer targeted proteomics assays to support preclinical and clinical studies.




• Innovate and implement new targeted proteomics analysis workflows, including automated enrichment strategies, to enable sensitive, precise, and scalable protein quantification.




• External Collaboration and Communication:




• Lead and oversee proteomics activities at CRO partners, including assay transfer, qualification, execution, and data quality oversight.




• Present scientific findings and strategic recommendations to project teams, senior leadership, and external collaborators in a clear, concise, and impactful manner.

Skills and experience you'll bring:

• PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with a minimum of 2 years of experience in targeted, mass spectrometry-based proteomics in an industry or startup biotech setting; or BS/MS with 8 years of relevant experience.




• Domain expertise in targeted proteomics, including:




• Demonstrated ability in translating key biological and pharmacodynamic questions into targeted proteomics strategies that inform discovery, translational, and clinical-stage decision making within fast-paced drug discovery environments.




• Development and deployment of highly multiplexed and sensitive PRM or MRM stable isotope-labeled peptide assays using DDA and DIA data.




• Development of immunoaffinity enrichment methods to enhance MS assay sensitivity.




• Knowledge of techniques for optimizing protein recovery from complex biological matrices (cells, tissues, biofluids) derived from human and preclinical species.




• Operation, maintenance, and troubleshooting of nanoLC and Orbitrap MS instrumentation.




• Quantitative analysis and report generation using Skyline and related quantitative proteomics data analysis tools.




• Domain leadership with cross-functional drug discovery :




• Highly organized, solutions-oriented scientist with the ability to manage multiple priorities simultaneously while driving innovation in targeted proteomics workflows and enabling program advancement through high-impact experimental data.




• Proven success collaborating effectively across multidisciplinary project teams as the proteomics subject matter expert, presenting data-driven recommendations to scientific leadership and cross-functional stakeholders.




• Excellent written and verbal communication skills, with the ability to convey complex scientific concepts to both technical and non-technical audiences.




• Experience preparing reports and supporting documentation for regulatory submissions, with understanding of regulatory requirements and compliance expectations.




• Experience managing external CRO partnerships, including assay transfer, study oversight, and qualification activities ensuring delivery of high-quality pharmacodynamic data that align with project timelines.

Equal Employment Opportunity

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.


• The anticipated base salary range for this role is $115,000 - $215,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.


• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.