Senior Scientist, Medicinal Chemistry

Initial Therapeutics, Inc.; Monrovia (CA); On-site; USD 150,000 - 219,000; Full time

Benefits offered by this job

Fully-paid medical benefits

Dental benefits

Vision benefits

Life insurance

Disability benefits

Retirement contribution

Stock option participation

Job summary

An innovative biotechnology firm is seeking a motivated synthetic chemist to join its dynamic medicinal chemistry team. In this role, you will leverage cutting-edge chemical datasets to design and synthesize small molecules, contributing to vital hit-to-lead and lead optimization projects. Collaborating closely with interdisciplinary teams, you will utilize your expertise in organic chemistry to interpret complex data and enhance molecular properties. This position offers an exciting opportunity to work at the forefront of drug discovery, where your contributions will have a significant impact on the development of new therapies. If you are passionate about chemistry and eager to drive scientific advancements, this role is perfect for you.

Qualifications

• Ph.D. or postdoc in organic chemistry with 2-5 years of industry experience.
• Bachelor's or Master's with 10-15 years of experience in biotech.

Responsibilities

• Design and synthesize bio-active molecules for lead optimization.
• Interpret potency and ADME data to uncover structure-activity relationships.
• Collaborate with AI teams for predictive modeling in compound design.

Skills

Synthetic Chemistry

Data Interpretation

Molecular Design

Machine Learning Integration

Multi-step Synthesis

Education

Ph.D. in Organic Chemistry

Master's in Organic Chemistry

Bachelor's in Organic Chemistry

Job description

Company Overview:
Terray Therapeutics is a venture-backed biotechnology company led by pioneers and long-time leaders in artificial intelligence, synthetic chemistry, automation, and nanotechnology. We’re generating chemical data purpose-built to propel drug discovery into the information age — and we’re doing it on a larger scale and faster than has ever before been possible. Our closed loop system generates precise chemical datasets at unrivaled scale that work seamlessly with AI to systematically map biochemical interactions between small molecules and causes of disease. Iterative cycles of virtual molecular design and experimentation power AI and machine learning models, which in turn guide the next cycle of design. With a chemistry engine that measures billions of interactions daily and becomes increasingly precise with every cycle, we can answer an unprecedented array of questions — deriving insights that enable us to predictably create drugs for patients in need.

Position Summary:
Terray is currently seeking a motivated and creative synthetic chemist to join our growing medicinal chemistry team. As an integral member of the Preclinical Development department, the candidate will contribute to hit-to-lead and lead optimization efforts across multiple programs, leveraging our vast chemical datasets and proprietary platforms to power state-of-the-art small molecule design and synthesis. In this interdisciplinary role, the candidate will work closely with teams from different functional areas in both Preclinical Development and Computational and Data Science (CDS) departments.

Core Responsibilities:

• Design and synthesize bio-active molecules for programs in hit-to-lead and/or lead optimization.
• Interpret large sets of potency, ADME and DMPK data to uncover structure-activity relationships.
• Optimize the properties for molecules across multiple series for in-vivo exposure and efficacy.
• Work closely with Machine Learning and AI teams to integrate predictive and generative modelling with compound design.
• Manage and/or assist in managing external chemistry efforts (CROs).

Experience and Qualifications:
Part of Terray’s success is nurtured by a hands-on work environment where everyone is accountable, vested in a vision of excellence, and actively taking part in the success of the business. Terray supports a positive work environment where employees can feel engaged, recognized and empowered to be creative.

Required Qualifications:

• Ph.D. or postdoc in organic or synthetic chemistry plus 2-5 years of experience in the biotech or pharmaceutical industries OR
• Bachelor’s or Master’s degree in organic or synthetic chemistry plus 10-15 years of experience in the biotech or pharmaceutical industries.
• Can demonstrate scientific initiative and creativity in multi-step synthesis and/or reaction methodology through primary authored peer-reviewed publications or patents.

Compensation Details:
$150,000 - $219,000 (annually) depending on experience; participation in the Company's option plan; 3% retirement safe harbor contribution; fully-paid medical, dental, vision, life and disability benefits.