Senior Scientist, In Vitro Pharmacology - Target Discovery

Gordian Biotechnology; South San Francisco (CA); Sur place; USD 138 000 - 193 000; Plein temps

Avantages offerts par ce poste

Equity

Comprehensive benefits (health, dental

401(k) with match

Onsite lunch

Onsite gym

Unlimited vacation

Résumé du poste

Gordian Biotechnology in South San Francisco seeks a Senior Scientist, In Vitro Pharmacology to build and validate assays for novel targets and to oversee the screening cascade with medicinal chemistry. You will also develop human-relevant models and manage CRO studies to ensure data quality aligns with internal standards.

You will lead the in vitro pharmacology effort, establish SOPs, and drive cross-functional collaboration with biology and chemistry to advance targets toward preclinical

Qualifications

• Ph.D. in pharmacology or related field preferred.
• Experience designing and validating biochemical, biophysical and cell-based assays.
• Experience managing CRO studies and external collaborations.

Responsabilités

• Design, develop and validate biochemical, biophysical and cell-based assays for novel targets.
• Oversee the screening cascade from hit identification to lead optimization.
• Define target engagement, mechanism of action and efficacy readouts in human systems.
• Direct CROs, transfer assays, and ensure data quality and readiness for decision meetings.
• Build and lead in vitro pharmacology capabilities and SOPs.

Connaissances

In vitro pharmacology

Assay development

CRO management

Data analysis

Pharmacology knowledge

Formation

Ph.D. in pharmacology/biochemistry/related field

Outils

TR-FRET/HTRF

AlphaLISA

SPR

Genedata/GraphPad

Description du poste

Gordian Biotechnology in South San Francisco seeks a Senior Scientist, In Vitro Pharmacology to build and validate assays for novel targets and to oversee the screening cascade with medicinal chemistry. You will also develop human-relevant models and manage CRO studies to ensure data quality aligns with internal standards.

You will lead the in vitro pharmacology effort, establish SOPs, and drive cross-functional collaboration with biology and chemistry to advance targets toward preclinical