Senior Scientist, Immunology

American Society of Gene & Cell Therapy; Cambridge, Northern (MA, KY); Hybrid; USD 126,000 - 182,000; Full time

Job summary

Serif Biomedicines is seeking a Senior Scientist of Immunology with expertise in T cell biology and in vivo CAR-T therapy development to join our therapeutic discovery team in Cambridge, MA. The candidate will focus on strategic planning and hands-on benchwork using in vitro and ex vivo approaches.

This role requires a PhD in Immunology with 5+ years of experience and a track record in flow cytometry, T cell assays, and in vivo models.

Qualifications

• PhD in Immunology with 5+ years of experience; industry experience preferred.
• Deep flow cytometry expertise: panel design, instrument setup, data analysis.
• Experience with primary T cells, PBMCs, and related assays.
• Experience with mouse models; humanized mice and NHP ex vivo analyses preferred.
• In vivo CAR-T experience strongly preferred.
• Experience with non-viral delivery and nucleic acid modalities preferred.
• Strong bench work and collaboration, with excellent organizational and communication skills.

Responsibilities

• Lead scientific strategies of independent projects or workstreams within a program.
• Design and execute complex in vitro CAR-T assays and functional readouts.
• Design and execute in vivo studies with humanized mice and NHPs; coordinate CROs/academia as needed.
• Develop, optimize, and troubleshoot protocols; maintain accurate ELN records.
• Analyze, interpret, and communicate data at meetings; contribute to project discussions.
• Collaborate across a multidisciplinary team and contribute as an independent contributor.

Skills

PhD Immunology

Flow Cytometry

Primary T Cells

Mouse Models

In vivo CAR-T

Non-viral Delivery

PBMC Handling

Communication Skills

Education

PhD in Immunology

Job description

Company Summary:

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.

Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture..

Position Summary:

We are seeking a highly motivated Senior Scientist of Immunology with expertise in T cell biology and in vivo CAR-T therapy development to join our therapeutic discovery team. The candidate will focus on strategic planning and hands-on benchwork using in vitro and ex vivo experimental approaches. This position requires scientific and technical expertise, and experience with pre-clinical disease models, scientific curiosity, and the desire to overcome scientific challenges and drive excellence. This individual will have the opportunity to be a major contributor to our lead program and work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative team.

Key Responsibilities:

• Contribute to and lead scientific strategies of independent projects or workstreams within a program
• Independently design and execute complex in vitro assays to evaluate CAR-T cell function, including multi-color flow cytometry, cytotoxicity assays and other functional readouts
• Independently design and execute in vivo studies, including humanized mice and NHPs and conduct ex vivo analysis of immune cells. Interact with CROs or academic collaborators for in vivo study related activities
• Develop, optimize and troubleshoot experimental protocols, and maintain accurate and timely electronic laboratory notebook records
• Analyze, interpret and communicate experimental data at lab and project team meetings
• Comfortable working both as an independent contributor and as part of a collaborative, multidisciplinary team of scientists

Qualifications:

• PhD. in Immunology or related field with 5+ years of relevant experience, industry experience preferred. Title will be commensurate with experience
• Deep expertise in flow cytometry, including panel design, instrument setup, and data analysis
• Experience handing primary T cells, human PBMC, and associated assays to determine T cell function and phenotype
• Experience with mouse models and ex vivo tissue processing and analyses. Experience in humanized mouse models and NHP ex vivo analyses is preferred
• Experience with in in vivo CAR-T is strongly preferred
• Experience with non-viral delivery technologies and nucleic acid modalities is preferred
• Highly motivated to execute at the bench, exceptional organizational, problem-solving, communication, and collaboration skills

We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidates.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto

Privacy Notice for Applicants:

When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [e-mail].

The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.

Privacy Notice for Applicants:

When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [e-mail].