Senior Scientist II, Rheumatology

BioSpace; Cambridge (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Paid time off

Medical/dental/vision insurance

401(k)

Job summary

AbbVie in Cambridge, MA seeks a Senior Scientist II to advance preclinical rheumatology programs. You will lead target validation, mechanism studies, and translational efforts to bridge human disease biology with preclinical data. Strong in vivo expertise and collaboration across teams are essential for success.

The role emphasizes in vivo KD/PD work, data integration, and generation of high-quality data packages to guide program strategy.

Qualifications

• Bachelor's degree with 12+ years of experience.
• Master's degree with 10+ years of experience.
• PhD with 4+ years of experience.

Responsibilities

• Set Rheumatology strategy for pipeline programs and contribute to target evaluation.
• Drive in vitro and in vivo pharmacology, establish PK/PD relationships, and optimize assays.
• Develop murine models of inflammation to support preclinical development.
• Apply flow cytometry, gene expression analysis, protein and cytokine quantification, histopathology.
• Design experiments, analyze data, and present findings at AbbVie scientific forums.
• Author and review technical reports, protocols, and other key documents.
• Adhere to corporate standards for safety and humane animal care.

Skills

Immunology

In vivo pharmacology

Data analysis

Flow cytometry

Scientific communication

Education

Bachelor's degree

Master's degree

PhD

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Job Description

AbbVies Discovery Immunology R&D organization is seeking a highly motivated and innovative Senior Scientist II to join the Rheumatology team at the Cambridge Research Center (CRC). This individual will support preclinical drug discovery programs in rheumatology, with focus on Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA). The role emphasizes target validation, mechanism-of-action studies, translational research, and advancement of novel therapeutic strategies. The ideal candidate will bring deep expertise in immunology and inflammation biology, strong preclinical pharmacology experience, and hands-on knowledge of in vivo disease models. Success in this role requires the ability to integrate human disease biology with preclinical approaches, generate high-quality data packages, collaborate cross-functionally, independently drive scientific initiatives, and contribute to program strategy.

Key Responsibilities Include

• Serve as a functional representative responsible for setting Rheumatology strategy for pipeline programs and contributing to target evaluation and model development.
• Drive in vitro and in vivo pharmacology for drug candidates, including establishing PK/PD relationships, developing, and optimizing screening assays, designing and executing mechanism-of-action studies, and evaluating candidate efficacy.
• Develop acute and/or chronic murine models of inflammation to support preclinical development of candidates for rheumatological and other autoimmune diseases.
• Apply immunological techniques such as flow cytometry, PCR/gene expression analysis, protein and cytokine quantification, histopathology, and other relevant functional readouts.
• Design experiments, analyze data, and present findings at AbbVie scientific forums and external conferences.
• Author and review technical reports, protocols, and other key scientific documents.
• Adhere to corporate standards related to code of conduct, documentation, safety, proper handling of materials, and humane treatment of laboratory animals.

Qualifications

• Bachelors Degree with 12 years of experience, Masters Degree with10 years of experience, PhD with 4 years of experience.
• Proven expertise in in vitro and preclinical in vivo model systems
• Excellent interpersonal, communication, and collaboration skills
• Ability to work effectively in a highly collaborative environment, including cross-functional teams and colleagues across multiple locations to support team and company goals.
• Prior experience in the pharmaceutical or biotechnology industry is preferred.

Key Leadership Competencies

• Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance.
• Learns fast, grasps the essence and can change course quickly as needed.
• Creates a learning environment, open to suggestions and experiments to drive science in the field of interest.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality

Additional Information

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof thisposting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission,incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless anduntil paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html