Senior Scientist I- Translational Medicine- PKS, ADME

Novartis Group Companies; Cambridge (MA); On-site; USD 89,600 - 166,400; Full time

Benefits offered by this job

Performance-based cash incentive

401(k) with company contribution

Generous time off package

Job summary

Novartis Group Companies in Cambridge is seeking a Senior Scientist I to support discovery projects through in-vitro ADME assays and develop lab automation capabilities. This role focuses on executing and advancing ADME methodologies while collaborating cross-departmentally.

The ideal candidate will have a relevant degree, substantial ADME experience in drug metabolism, and knowledge of analytical techniques. The position offers a competitive salary and comprehensive benefits.

Qualifications

• BSc: 7+ years; MSc: 4+ years of ADME/DMPK experience.
• Experience in drug discovery and development laboratory is highly desirable.
• Knowledge of related disciplines in drug discovery processes.
• Fluent oral and written English.

Responsibilities

• Plan, execute and report ADME assays.
• Advance laboratory automation strategies.
• Communicate data and strategy effectively with project teams.
• Contribute to internal ADME study reports and regulatory documents.

Skills

ADME assays

Laboratory automation

Drug metabolism

Pharmacokinetics

Collaboration

Education

BSc or MSc in relevant field

Tools

LCMS-MS

HRMS

ICP-MS

Job description

Job Description Summary

LI#-Onsite
Location: Cambridge
Internal Title: Senior Scientist I

Support discovery and development projects through the design, development, and execution of in‑vitro ADME assays, while building next generation lab automation capabilities to deliver high‑quality study data for informed decision‑making.

Job Description

Key Responsibilities

• Plan, execute and report ADME assays such as metabolic stability and permeability to support PK Science's strategies.
• Interpret in‑vitro ADME data and translate findings to support early discovery, compound optimization and selection.
• Contribute to novel ADME methodologies and expand assay capabilities.
• Advance automation strategies (e.g., liquid handling, assay miniaturization, assay multiplexing) to expand laboratory capacity, standardize execution to reduce manual effort, and strengthen discovery assay operations.
• Execute and/or contribute to fully automated, end‑to‑end ADME assay workflows integrated with AI‑enabled analytics.
• Develop methods to support small and large molecule bio‑analysis using LCMS‑MS, HRMS, and ICP‑MS techniques.
• Troubleshoot lab instrumentation and automation platforms.
• Manage study timelines, objectives and budgets, ensure accuracy of project progress in company tracking tools.
• Under management supervision, work to effectively communicate data, strategy and results to the project teams.
• Contribute to internal ADME study reports and regulatory documents (IND, IMPD, NDA, etc.).
• Participate in cross‑departmental teams, department‑wide initiatives and work streams.
• Complete all required organizational trainings and requirements according to corporate timelines.
• Adhere in strict accord to the appropriate SOP, quality and HSE guidelines.

Essential Requirements

• BSc or MSc with relevant experience in drug metabolism and pharmacokinetics or related field.
• BSc: 7+ years; MSc: 4+ years of ADME/DMPK experience.
• Experience working in a drug discovery or development laboratory or relevant experience in a CRO, Pharma or Biotech is highly desirable.
• Experience in metabolic stability and permeability assays highly preferable; cell culture experience is a plus.
• Experience with laboratory automation integrated with AI‑enabled analytics is highly desirable.
• Knowledge of related disciplines (e.g., bioanalytical, toxicology, biomarker) in the drug discovery or development process.
• Ability to work as part of a cross‑functional team in a highly dynamic, matrixed, project‑team environment.
• Strong organizational and project skills with critical thinking and problem‑solving skills.
• Fluent oral and written English.

The salary for this position is expected to range between $89,600 and $166,400 per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance‑based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US‑based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e‑mail to [e-mail] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

$89,600.00 - $166,400.00

Skills Desired

• Adobe Photoshop
• Chemistry
• Collaboration
• Compensations Management (Employees) (Inactive)
• Curious Mindset
• Drug Development
• Employee Recruitment
• Flexibility (Inactive)
• Oscilloscope
• Patient Care
• Pipeline (Software) (Inactive)
• Sales
• Small Businesses
• Teamwork