Senior Scientist I, LNP Platform

SmartRecruiters, Inc.; Worcester (MA); On-site; USD 97,000 - 184,000; Full time

Benefits offered by this job

Comprehensive benefits

Short-term incentive programs

Job summary

AbbVie in Worcester, MA is seeking a Senior Scientist I to lead novel lipid nanoparticle formulation and process development. This hands-on role requires independent technical leadership in a wet-lab setting and collaboration with cross-functional teams.

You will mentor junior scientists, design experiments (DOE), and drive data-driven decisions to advance tLNP drug product programs, while ensuring SOP-compliant documentation and reporting.

Qualifications

• Requires advanced education with leadership in formulation, drug product, or process development.
• Experience leading projects from concept through execution and data-driven decision-making.
• Strong expertise in LNP formulation development and nanoparticle characterization.

Responsibilities

• Independently propose, design, lead, and manage novel technical projects focused on LNP formulation and process development.
• Serve as a technical lead for complex formulation and process development activities with project plans, timelines, and data-driven recommendations.
• Lead DOE-based experiments to optimize LNP formulations and manufacturing processes.
• Provide mentorship to junior scientists and guide experimental design and data analysis.
• Drive root-cause investigations and implement corrective actions.
• Represent projects in cross-functional teams and communicate strategies to stakeholders.
• Prepare technical reports, presentations, and SOPs with clear documentation.

Skills

LNP formulation development

Drug product development

Project leadership

Mentorship

DOE design

Nucleic acid delivery

Nanoparticle characterization

Education

PhD in relevant field

Master’s degree in relevant field

Bachelor’s degree in relevant field

Tools

DOE-based experimental design tools

Job description

• Compensation: USD 96,500 - USD 183,500 - yearly

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

Job Description

We are currently hiring a highly motivated Senior Scientist I to join our LNP Platform team. In this role, you will serve as an independent technical lead for novel LNP formulation/process development of emerging tLNP drug product programs.

This position will report into the Principal Scientist and based at our Worcester office. This role will involve hands-on laboratory work. All duties will be performed in compliance with AbbVie's standard operating procedures (SOPs).

Experience in lipid nanoparticle formulation and purification processes, or experience with process development, engineering and manufacturing of biologics drug product processes are highly desired.

Responsibilities & Duties:

• Independently propose, design, lead, and manage novel technical projects focused on formulation, conjugation, purification, and process development for targeted lipid nanoparticle-based nucleic acid formulations.
• Serve as a technical lead for complex formulation and process development activities, including development of project plans, timelines, experimental strategies, risk assessments, and data-driven recommendations.
• Lead DOE-based experimental design, execution, analysis, and interpretation to optimize LNP formulations, and associated manufacturing processes.
• Provide technical direction and mentorship to junior and associate scientists, including guidance on experimental design, data analysis, troubleshooting, documentation, and prioritization of project activities.
• Drive technical problem-solving and root-cause investigations for aberrant results, process variability, or formulation performance issues, and recommend scientifically justified corrective actions.
• Represent your project in cross-functional project teams, communicating technical strategy, progress, risks, and recommendations to stakeholders and leadership.
• Prepare high-quality technical reports, presentations, protocols, batch records, and SOPs, ensuring clear documentation of scientific rationale, experimental outcomes, and development decisions.

Qualifications

• Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary.
• Demonstrated ability to independently lead formulation, drug product, or process development projects from concept through execution and data-driven decision-making.
• Strong expertise in LNP formulation development, nucleic acid delivery, nanoparticle characterization, and/or lyophilized drug product development.
• Proven ability to troubleshoot complex formulation or process challenges and develop scientifically sound mitigation strategies.
• Experience providing technical guidance, mentorship, or matrix leadership to junior colleagues.
• Strong project management skills, including ability to prioritize work, manage timelines, coordinate contributors, and communicate risks.
• Excellent written and verbal communication skills, including ability to present complex technical data and recommendations to cross-functional and senior audiences.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employer remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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