Senior Scientist, Human Tissue Modeling & Automation

Bison; San Francisco (CA); On-site; USD 120,000 - 160,000; Full time

Job summary

Vivodyne is seeking a Senior Scientist on the Bioengineering team in San Francisco to lead the development, optimization, and scaling of advanced human tissue models for Vivodyne’s automated experimentation platform dedicated to therapeutic discovery.

You will own a scientific program from early hypothesis generation through mature, scalable workflows, collaborating with bioengineers, computational biologists, AI scientists, roboticists, hardware engineers, and translational researchers to

Qualifications

• PhD in bioengineering or related field; focus on gut, lung or immuno-biology is a plus.
• 2–4 years of industry experience after PhD or postdoc.
• Demonstrated record of scientific achievement through publications, patents, or awards.
• Deep expertise in mammalian cell culture with primary human cells and 3D tissue models.
• Experience with biomolecular and cellular characterization techniques: confocal imaging, flow cytometry, transcriptomics, proteomics, NGS, and data interpretation.
• Proven ability to independently drive complex technical programs in fast-paced R&D environments.

Responsibilities

• Lead development and optimization of complex in vitro human tissue models using primary human cells and advanced 3D culture systems.
• Design, execute, and interpret rigorous experiments with proper controls to improve tissue phenotype, stability, scalability, reproducibility, and relevance.
• Drive mechanistic understanding of tissue behavior through multimodal characterization approaches.
• Troubleshoot difficult experimental problems using first-principles reasoning and quantitative analysis.
• Partner with robotics and hardware teams to adapt tissue workflows for automated operation and large-scale experimentation.
• Support transfer of tissue models from R&D into production-grade workflows.
• Identify sources of variability and implement strategies to improve robustness and reproducibility.
• Contribute to scalable assay and tissue characterization pipelines.

Skills

Mammalian cell culture

3D tissue models

Confocal imaging

Flow cytometry

Transcriptomics

Proteomics

NGS workflows

Data interpretation

Project leadership

R&D program management

Education

PhD in bioengineering or related field

Job description

Vivodyne is seeking a Senior Scientist on the Bioengineering team in San Francisco to lead the development, optimization, and scaling of advanced human tissue models for Vivodyne’s automated experimentation platform dedicated to therapeutic discovery.

You will own a scientific program from early hypothesis generation through mature, scalable workflows, collaborating with bioengineers, computational biologists, AI scientists, roboticists, hardware engineers, and translational researchers to