Senior Scientist Genomic Medicine BioAnalytics Characterization

Sanofi; Waltham (MA); On-site; USD 101,000 - 145,000; Full time

Benefits offered by this job

Parental leave (14 weeks)

Health benefits

Job summary

Sanofi in Waltham, MA is seeking a Senior Scientist to advance genomic medicine bioanalytics characterization for gene therapy candidates. You will lead LC-MS-based protein characterization, monitor impurities, and collaborate across process development, CMC, and regulatory teams. Candidates should have a Ph.D.

in Biochemistry or chemistry-related field (or MS with 4+ years industry). Expertise with Thermo/AB Sciex LC-MS systems and proteomics software is preferred.

Qualifications

• Ph.D. in Biochemistry or Chemistry-life science field or MS with 4+ years of industry experience.
• Extensive LC-MS experience in protein characterization, identification and quantitation.
• Strong proficiency with Thermo and/or AB Sciex instruments and key proteomics software.

Responsibilities

• Develop and implement advanced characterization strategies for gene therapy candidates (viral vectors and nonviral particles).
• Utilize LC-MS to profile HCP clearance and monitor impurities of concern for CMC development.
• Establish method detection limits and transfer to automated sample prep.
• Profile differential protein expression in cell lysates to support Cell Culture Process Development.
• Develop LC-MS methods for nonviral particles including RNA impurity determination and oligonucleotide mapping.
• Collaborate cross-functionally to support process/formulation development via LC-MS characterization.

Skills

LC-MS characterization

Protein quantitation

Proteomics software

Education

Ph.D. in Biochemistry or Chemistry-life science

Tools

Thermo instruments

AB Sciex instruments

Spectronaut

Protein Metrics

Skyline

Proteome Discoverer

Job description

Senior Scientist Genomic Medicine BioAnalytics Characterization

Location: Waltham, MA

About the Job

We are seeking a motivated Senior Scientist to join our BioAnalytics Characterization group in the Genomic Medicine Unit within Sanofi. Candidates with no previous experience in the field of genomic medicine are still encouraged to apply – we are looking primarily for someone with strong mass spectrometry characterization experience and are committed to bridging any knowledge gaps through dedicated onboarding and training. This role offers a unique opportunity to build expertise in the rapidly growing field of genomic medicine, including viral gene therapies and lipid nanoparticles. The future of medicine is being shaped today at Sanofi — The Genomic Medicine Unit at Sanofi is dedicated to the establishment of best-in-class platforms to support development of life-changing advanced gene therapy products. The BioAnalytics Characterization group uses advanced analytical techniques for in-depth structural and functional characterization of gene therapy products in support of drug development, from pre-candidate selection through commercialization. Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities

• Develop and implement advanced characterization strategies for gene therapy candidates, including viral vectors and nonviral particles
• Utilize a robust and sensitive LC-MS platform to profile HCP clearance throughout purification process and quantitatively monitor impurities of concern to support CMC product development
• Establish HCP impurity method detection limits and precision, and oversee transfer and comparability to automated sample preparation methods within facility
• Utilize LC-MS proteomics platform in profiling differential protein expression in cell lysates to support Cell Culture Process Development
• Develop LC-MS characterization methods of nonviral particles including RNA impurity determination and oligonucleotide mapping
• Collaborate cross functionally and support process/formulation development through comprehensive LC-MS characterization (peptide mapping, HCP analysis, and oligonucleotide analysis)
• Establish new end-to-end automated data workflows (e.g. from data upload and application specific data processing to reporting in ELN)
• Author technical documentation including reports, protocols, and regulatory filings (IND/IMPD/BLA)
• Contribute to scientific literature and present at internal and external conferences

Education

Ph.D. in Biochemistry or Chemistry-life science related field, OR M.S. with 4+ years of industry experience

Experience & Technical Skills

• Extensive LC-MS experience in protein characterization, identification and protein quantitation
• Proficiency with Thermo and/or AbSciex instruments and at least one peptide mapping/proteomics software such as Spectronaut, Genedata Expressionist, Protein Metrics, Skyline, or Proteome Discoverer
• Demonstrated success implementing novel analytical technologies

Preferred Qualifications

• Experience with automation and AI-driven analytical workflows is highly desirable.

Professional Skills

• Excellent organizational and problem-solving abilities
• Strong interpersonal and communication skills
• Ability to work collaboratively in cross-functional teams

Why Choose Us

• Bring the miracles of science to life alongside a supportive, future focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave
• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.
• Help improve the lives of millions of people globally by making drug development quicker and more effective.

Equal Opportunity Statement

Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

US and Puerto Rico Residents Only Sanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

North America Applicants Only

The salary range for this position is: $100.500,00 - $145.166,66 All compensation will be determined commensurate with demonstrated experience.

Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

We are an R&D driven, AI-powered biopharma company committed to improving people’s lives and creating compelling growth. Our team is guided by one purpose: we chase the miracles of science to improve people’s lives. We want to build a healthier, more resilient world, and turn the impossible into the possible by discovering, developing, and delivering medicines and vaccines for millions of people around the world.

Discover more about us visiting www.sanofi.com or via our movie We are Sanofi Start a career that makes a difference. Reinvention is in our DNA. It’s what drove our evolution from a small French enterprise to one of the world’s leading biopharma companies. Whether it’s using AI to shorten drug-discovery times or building trust in healthcare, you could be helping our teams make life better for patients, partners, and communities.

This is where you grow your career. We open the door for you to explore new opportunities, push your limits, and connect with people who are driven by a shared purpose: we chase the miracles of science to improve people’s lives.