Senior Scientist, Functional Sciences, Discovery Biotherapeutics

Bristol-Myers Squibb; Virginia (MN); On-site; USD 141,000 - 171,000; Full time

Benefits offered by this job

Flexible Time Off

11 company holidays

Comprehensive benefits

Job summary

Bristol Myers Squibb is seeking a Senior Scientist, Functional Sciences to lead the design and execution of cellular assays for antibody-based biologics. You will work on mechanistic readouts, target validation, and cross-functional collaboration in a dynamic team focused on oncology and immunology.

The role involves mentoring junior scientists, applying automation and data visualization tools, and contributing to discovery strategies in a fast-paced environment at Cambridge Crossing.

Qualifications

• 7+ years of academic/industry experience with a Bachelor’s degree or 5+ years with a Master’s; 2+ years with a PhD.
• Academic degree in molecular/cell biology with immunology or oncology focus preferred
• Hands-on cellular assay design and execution with multiple readouts; experience with antibodies/biologics required
• Experience with automation and data analysis tools to interpret functional screening results

Responsibilities

• Design and implement cellular screening assays for antibodies and biologics.
• Develop mechanistic assays for TCEs and ADCs.
• Create cell lines or source commercial lines for assays.
• Characterize protein reagents for in vitro selection.
• Participate in target ideation and test hypotheses.
• Apply automation/AI-ML to screening workflows.
• Present data to cross-functional teams.
• Document experiments in Electronic Notebook (Benchling).

Skills

Flow cytometry

Imaging (Incucyte)

Automation

Data analysis

Biologics experience

Education

Bachelor's degree with 7+ years

Master's degree with 5+ years

PhD with 2+ years

Molecular/cell biology with immunology/oncology focus

Tools

Benchling

GraphPad Prism

Spotfire

Incucyte software

Job description

Summary

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Roles and Responsibilities

• Design and implement relevant cellular screening assays for antibody-based biologics to identify and characterize lead candidates using diverse technologies in immortalized and primary cells
• Develop and execute mechanistic assays based on the antibody therapeutic modality and target candidate profile, such as for T cell engagers, Antibody Drug Conjugates, multi-specifics, agonists/ antagonists
• Generate relevant cell lines or explore commercial sources to design the appropriate functional screening assays including reporter assays, AlphaLISA, flow-or imaging-based effector function readout assays, co-culture systems
• Characterize protein reagents to be used as targets for in vitro selection or assay components by biochemical or cell-based methods
• Participate in target ideation and generation of testable hypotheses for target validation
• Identify new technologies and/or process enhancements leveraging automation and AI/ML tools to improve screening and data analysis workflows
• Serve as Discovery Biotherapeutics assay representative on matrixed multi-disciplinary project teams; design functional screening strategy and present data to stakeholders
• Document experiments meticulously in Electronic Notebook and upload assay data into Benchling Experience

Experience, Education and Specialized Knowledge and Skills

• Bachelor's Degree with 7+ years of academic / industry experience OR Master's Degree with 5+ years of academic / industry experience OR PhD with 2+ years of academic / industry experience
• Academic degree and research experience in molecular and cell biology with specialization in immunology or oncology strongly preferred
• Ability to apply scientific concepts in immunology and cancer biology along with strong technical skills to design, execute and interpret functional characterization assays
• Hands-on experience in designing and executing cellular assays with a variety of readouts to dissect mechanism of action and function of potential therapeutics; prior experience working with antibodies and biologics is required; experience working on TCEs and/or ADCs would be a plus
• Flow cytometry, Incucyte or imaging experience a must; experience with other cellular assay technologies and instrumentation would be a plus
• Experience with automation and assay miniaturization is desirable
• Experience with analysis and data visualization tools like Graphpad Prism, Spotfire would be a plus
• Experience serving on cross-functional project teams is a plus
• Excellent organizational, analytical and technical skills are required, along with demonstrated initiative-taking and innovative thinking to implement new experimental technologies and develop approaches to solve complex problems
• Excellent communication skills to effectively serve as the Functional Sciences representative in multi-disciplinary project teams
• Ability to work with a sense of urgency and support multiple projects simultaneously
• Passionate scientist and collaborator with a strong work ethic and willingness to mentor junior scientists

Compensation Overview

Cambridge Crossing: $141,310 - $171,238
The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability). U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year. Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays. Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day. U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Candidate Rights (Los Angeles County)

For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If this posting is missing required information required by local law or incorrect, contact BMS at [e-mail] the Job Title and Requisition number. Do not send application-related inquiries to this email. R1605993 : Senior Scientist, Functional Sciences, Discovery Biotherapeutics

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We’re creating innovative medicines for patients fighting serious diseases. We’re also nurturing our own diverse team with inspiring work and challenging career options. No matter the role, each one of us makes a contribution. And that makes all the difference.