Senior Scientist, Functional Genomics

Xaira Therapeutics; South San Francisco (CA); On-site; USD 136,000 - 170,000; Full time

Benefits offered by this job

Equity

Base salary + bonus + benefits

Open, flexible environment

Job summary

Xaira Therapeutics in the San Francisco Bay Area is seeking a Senior Scientist to architect and lead in vivo CRISPR screening. You will push high-throughput functional genomics at the intersection of mouse models, AI/ML, and translational biology to accelerate therapeutic discovery.

The role combines independent project leadership with hands-on development of screening protocols, data interpretation for cross-functional teams, and mentorship of junior staff, aiming to deliver robust datasets and

Qualifications

• Ph.D. in Molecular Biology, Genetics, Pharmacology, or a related field; 4+ years postdoc/industry experience.
• Experience with in vivo genetic manipulation (lentiviral/AAV) in mice; animal handling and welfare.
• Familiarity with perturb-seq and single-cell genomics.
• Ability to troubleshoot, adapt protocols, and optimize in vivo methodologies.
• Excellent scientific communication and collaboration skills.

Responsibilities

• Develop, optimize and scale high-throughput CRISPR-based screening in mouse models.
• Drive innovation in experimental workflows and screening methodologies.
• Collaborate with computational biology, AI/ML, and drug discovery teams to interpret large functional genomics datasets.
• Identify and resolve data generation challenges including reproducibility and throughput.
• Manage multiple projects and deliver high-quality data on deadlines.
• Maintain detailed records and contribute to scientific presentations.

Skills

4+ years postdoc/industry

In vivo genetic manipulation

Mouse handling & colony management

Data analysis (Python/R)

Scientific communication

Education

Ph.D. in Molecular Biology/Genetics/Pharmacology or related field

Tools

Lentiviral delivery

AAV delivery

Perturb-seq

Single-cell genomics

Python

R

Job description

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

We are seeking an exceptional and highly motivated Senior Scientist to architect and lead our efforts in in vivo CRISPR screening. In this pivotal role, you will be instrumental in advancing our mission to pioneer biological discoveries through high-throughput functional genomics. You will lead strategic initiatives that push the technical boundaries of genetic screening at the intersection of mouse models, data science, AI/ML, and translational biology. This position is ideal for a seasoned discovery scientist who excels at translating data-driven insights into therapeutic research while balancing strategic leadership with advanced individual technical contributions.

Key Responsibilities

• Develop, implement and scale high-throughput CRISPR-based screening protocols in mouse models to uncover genotype-phenotype relationships at scale.
• Drive continuous innovation in experimental workflows and screening methodologies.
• Partner with computational biology, AI/ML, and drug discovery teams to analyze, interpret, visualize, and communicate findings from large-scale functional genomics datasets.
• Identify and resolve challenges in data generation, including assay reproducibility, sample throughput, and quality control.
• Independently manage multiple projects, ensuring timely delivery of high-quality data and adherence to team goals.
• Maintain accurate records of experiments, protocols, and findings, contributing to internal and external scientific presentations.
• Mentor junior staff and research associates, fostering their scientific and professional growth through active technical guidance and career development.
• Lead strategic project planning and long-term program development initiatives to ensure alignment with broader therapeutic discovery goals.
• Independently drive and oversee complex cross-functional collaborations with internal and external partners to accelerate program milestones.

Requirements

• Ph.D. in Molecular Biology, Genetics, Pharmacology, or a related field, with 4+ years of postdoctoral or industry experience.
• Strong experience with in vivo genetic manipulation (e.g., lentiviral or AAV delivery in mice), mouse handling, colony management, and in vivo experimentation, with an understanding of animal welfare and regulatory standards.
• Familiarity with perturb-seq and single-cell genomics.
• Ability to troubleshoot technical issues, adapt to new protocols, and optimize methodologies for in vivo applications.
• Excellent written and verbal communication skills, with a track record of presenting complex scientific results to multidisciplinary teams.
• Demonstrated success in working collaboratively in a fast-paced, team-oriented environment.

Preferred Qualifications

• Familiarity with spatial omics and interest in exploring new readout methods.
• Experience in data analysis using Python or R.

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $136,000 - $170,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.