Senior Scientist, Engineered Cell Therapy Discovery

Bristol Myers Squibb; Seattle (WA); On-site; USD 136,000 - 165,000; Full time

Benefits offered by this job

Health Coverage

Wellbeing Programs

Financial Protection

Job summary

Bristol Myers Squibb in Seattle is seeking a Senior Scientist to join the Engineered Cell Therapy Discovery team. You will independently drive CAR T and eTCR projects, design complex studies, and translate results into science-driven decisions.

The role requires mentorship of junior staff and collaboration across disciplines to advance transformative therapies. Ideal candidates have deep T cell immunology expertise, hands-on experience with gene editing and cell engineering, and strong

Qualifications

• Thorough knowledge of T cell immunology and immuno-oncology.
• Understanding of drug discovery and development processes.
• Hands-on experience with in vitro technologies to engineer and assess T cells.
• Experience analyzing large datasets (flow, imaging, etc.) using JMP/R/Programming.
• Ability to manage multiple workstreams and coordinate cross-functional teams.
• Strong written and verbal scientific communication.

Responsibilities

• Characterize engineered CAR/eTCR T cells to inform decisions.
• Design and execute screening strategies and mechanistic studies.
• Work independently on project deliverables and propose protocols.
• Interpret complex cellular and molecular data to identify trends.
• Lead multidisciplinary discussions and present key findings.
• Mentor junior team members and act as technical contact.
• Contribute to patents/publications and program teams.
• Maintain electronic notebooks to support milestones.

Skills

T cell immunology

Immuno-oncology

Drug discovery process

In vitro technologies

Data analysis

Project management

Collaboration skills

Critical thinking

Education

Bachelor’s Degree w/ 7+ years of academic and / or industry experience

Master’s Degree w/ 5+ years of academic and / or industry experience

Ph.D. or equivalent advanced degree in the Life Sciences w/ 2+ years of academic and / or industry experience

Job description

Working with Us

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Working with Us

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Cell Therapy Thematic Research Center is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next-generation, engineered cell-based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes.

Here, you will get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary

We are seeking an experienced and highly motivated Senior Scientist to join the Engineered Cell Therapy Discovery team and help drive next-generation CAR T and eTCR therapies for patients with cancer and other chronic diseases. In this role, you will independently participate and/or manage project workstream(s), design and interpret complex studies of engineered T cell biology, and translate results into science-driven decisions. You will exercise independence and latitude in advancing your project(s), serve as a technical point of contact within the team, and mentor more junior colleagues. The ideal candidate combines deep T cell immunology expertise with the judgment to work through ambiguous, complex problems under limited supervision.

Position Responsibilities

• Applies thorough knowledge of T cell immunology (activation, signaling, differentiation, exhaustion, and immune-regulation pathways) and developed knowledge of antibody properties to conduct experiments characterizing engineered CAR/eTCR T cells to enable science-driven decision-making.
• Designs, coordinates and executes screening strategies and fine-detailed, nuanced mechanistic studies that assess engineered T cell constructs and functional responses leveraging automation where applicable, enabling data-driven prioritization of candidates, in accordance with project and department objectives.
• Works independently on deliverables in managing assigned project workstream(s); suggests modifications to protocols or alternative protocols, introducing new ideas on how to design, execute, and analyze experiments, routinely using the scientific literature and internal BMS datasets to solve problems.
• Interprets and synthesizes complex datasets from cellular, molecular, and functional assays (flow cytometry, IncuCyte, MSD, high-content imaging) to identify biological trends, guide experimental follow-up, and prioritize candidates.
• Leads discussions and makes presentations in multidisciplinary meetings, logically presenting information to convey clear, key messages, and is expected to explain, persuade, and build alignment.
• Acts as a functional mentor to more junior team members and may serve as a technical point of contact within the work group/project team.
• May participate in the development of patent applications and publications, and may represent the department or function on a program/project team or sub-team.
• Maintains electronic notebooks rigorously and in a timely manner to support project milestones and patent/regulatory filings.

Experience =

Basic Qualifications

• Bachelor’s Degree w/ 7+ years of academic and / or industry experience

Or

Basic Qualifications

• Master’s Degree w/ 5+ years of academic and / or industry experience

Or

Basic Qualifications

• Ph.D. or equivalent advanced degree in the Life Sciences w/ 2+ years of academic and / or industry experience

Preferred Qualifications

• Thorough knowledge of T cell immunology, immuno-oncology, or a related specialized discipline, with developed knowledge of adjacent disciplines (e.g., bioengineering, molecular biology).
• Developing knowledge of the drug discovery/development process and proficiency in scientific/technical writing (protocols, reports, contributions to regulatory documents).
• Extensive hands‑on experience with in vitro technologies used to engineer and functionally assess T cells (viral transduction, targeted gene editing, MSD/ELISA, IncuCyte, multi‑parameter flow cytometry, imaging).
• Experience analyzing large/complex datasets (e.g., multiparametric flow, NGS) using JMP, R, or a programming language is strongly desired.
• Demonstrated ability to independently identify problems and recommend/develop solutions; strong project‑management orientation across multiple concurrent workstreams.
• Strong interpersonal and collaboration skills in a matrixed, cross‑functional environment; ability to work productively as both a team member and an independent contributor.
• Skilled at critical and probabilistic thinking, able to apply prior experience and theoretical knowledge to identify and solve complex scientific problems

Compensation Overview

Seattle - WA: $136,030 - $164,841

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job‑related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefits

• Health Coverage: Medical, pharmacy, dental and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well‑being and Protection: 401(k) plan, short‑and‑long term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support and survivor support.

Work‑life Benefits Include

• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non‑Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part‑time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

• Eligibility Disclosure: The summer hours program is for United States (U.S.) office‑based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote‑by‑design or lab‑based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

Uniquely Interesting Work, Life‑changing Careers

With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On‑site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site‑essential, site‑by‑design, field‑based and remote‑by‑design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site‑essential roles require 100% of shifts onsite at your assigned facility. Site‑by‑design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field‑based and remote‑by‑design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

Responsibilities

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site‑essential, site‑by‑design, field‑based and remote‑by‑design jobs.

Supporting People With Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at [e-mail]. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley.

R1604206 : Senior Scientist, Engineered Cell Therapy Discovery